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Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Zusätzlich bieten wir Ihnen Collagen, Type III Antikörper (189) und Collagen, Type III Kits (59) und viele weitere Produktgruppen zu diesem Protein an.
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this study demonstrated that thrombin and factor Xa cleavage sites on HEV pORF1 are obligatory for HEV replication.
increased frequency of factor V Leiden (zeige F5 Proteine) G1691A and prothrombin (zeige F2 Proteine) G20210A mutation in venous thromboembolism patients indicates a significant role of these mutations in the development of VTE in the Kashmiri population
The results suggest that an increased plasma thrombin (zeige F2 Proteine) potential is characteristic in patients with clinically stable coronary artery disease, irrespective of previous myocardial infarction history and independent of traditional cardiovascular risk factors.
Enhanced thrombin (zeige F2 Proteine) generation is driven in asthma by a systemic inflammatory state mediated by IL-6 (zeige IL6 Proteine) and to a lesser extent TNFalpha (zeige TNF Proteine), however, not periostin (zeige POSTN Proteine). TNFalpha (zeige TNF Proteine) might contribute to impaired fibrinolysis.
Endogenous thrombin (zeige F2 Proteine) potential measured in presence of thrombomodulin (zeige THBD Proteine) is enhanced in patients with intracranial atherosclerotic disease (ICAD (zeige DFFA Proteine)), supporting that thrombomodulin (zeige THBD Proteine)-protein C (zeige PROC Proteine) pathways is relevant in transient ischaemic attacks from ICAD (zeige DFFA Proteine).
PIVKA II, when combined with AFP (zeige AFP Proteine), may be considered as a screening test for hepatocellular carcinoma due to its high negative predictive value.
Thrombin (zeige F2 Proteine) activated platelet releasing exosomes convey miRNA between cells. miRNA-223 regulates the expression of molecules adhesion including ICAM-1 (zeige ICAM1 Proteine). miRNA-223 downregulated ICAM-1 (zeige ICAM1 Proteine) mainly by impacting NF-kappaB (zeige NFKB1 Proteine) and the MAPK (zeige MAPK1 Proteine) pathway.
Thrombin (zeige F2 Proteine) binding to extra-cellular loop II (ECLII) of PAR4 (zeige PAWR Proteine) is important for its cleavage and activation of PAR4 (zeige PAWR Proteine).
These findings suggest that contraction-dependent TGF-beta (zeige TGFB1 Proteine) activation could be a mechanism by which thrombin (zeige F2 Proteine) leads to the development of asthmatic airway remodeling.
Case Report: Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation I prothrombin (zeige F2 Proteine).
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin (zeige F2 Proteine) generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin (zeige F2 Proteine)-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin (zeige F2 Proteine) carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (zeige BGN Proteine) plays a protective role during the progression of atherosclerosis in ApoE (zeige APOE Proteine)-deficient mice by inhibiting thrombin (zeige F2 Proteine) generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (zeige GP1BA Proteine)-binding and heparin-binding site of thrombin (zeige F2 Proteine)
thrombin (zeige F2 Proteine)/PAR-1 (zeige MARK2 Proteine) interaction regulated MCP-1 (zeige CPT1B Proteine), TF, MCSF (zeige CSF1 Proteine) and IL-6 (zeige IL6 Proteine) production.
Observations illustrate the role of thrombin (zeige F2 Proteine) as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (zeige SERPINC1 Proteine) nanoparticle therapeutics.
Thrombin (zeige F2 Proteine)-PAR1 (zeige F2R Proteine) signaling, via nitric oxide and EPCR (zeige PROCR Proteine), promotes hematopoietic stem cell (HSC (zeige FUT1 Proteine)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin (zeige F2 Proteine) promotes sustained signaling and inflammatory gene expression through the CDC25 (zeige CDC25C Proteine) and Ras-associating domains of phospholipase C epsilon (zeige PLCE1 Proteine).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2