Collagen, Type III Proteine (COL3)

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Zusätzlich bieten wir Ihnen Collagen, Type III Antikörper (169) und Collagen, Type III Kits (69) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
COL3 2147 P00734
Maus COL3 COL3 14061 P19221
COL3 29251  
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Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Human Unkonjugiert Western Blot of COLLAGEN III Lane 1: Human Collagen III Load: 100 ng per lane Primary antibody: Collagen III Antibody at 1:1000 o/n at 4°C Secondary antibody: 649 Goat anti-rabbit at 1:20,000 for 30 min at RT Block: ABIN925618 for 30 min at RT Predicted/Observed size: 138 kDa, 138 kDa 500 μg Anmelden zum Anzeigen 5 bis 7 Tage
$457.50
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Cow Rind (Kuh) Unkonjugiert   500 μg Anmelden zum Anzeigen 5 bis 7 Tage
$418.50
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Human Human Unkonjugiert Lane 1: Human Collagen III. Load: 100 ng per lane. Primary antibody: Collagen III antibody at 1:1000 ON at 4 deg C. Secondary antibody: Dylight (TM) 649 Goat anti-rabbit at 1:20, 000 for 30 min at RT. Block for 30 min at RT. 500 μg Anmelden zum Anzeigen 9 bis 11 Tage
$561.36
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Cow Rind (Kuh) Unkonjugiert   10 mg Anmelden zum Anzeigen 6 bis 8 Tage
$202.43
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Ratte Ratte Unkonjugiert   10 mg Anmelden zum Anzeigen 6 bis 8 Tage
$202.43
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Yeast (Pichia pastoris) Human Unkonjugiert   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$115.00
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Human Human Unkonjugiert   0.5 mg Anmelden zum Anzeigen 11 bis 16 Tage
$1,009.16
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Human Human Unkonjugiert   0.5 mg Anmelden zum Anzeigen 2 bis 3 Tage
$708.40
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Yeast (Pichia pastoris) Human Unkonjugiert   10 mg Anmelden zum Anzeigen 2 bis 3 Tage
$424.62
Details
Cow Rind (Kuh) Unkonjugiert   0.5 mg Anmelden zum Anzeigen 3 bis 4 Tage
$282.00
Details

COL3 Proteine nach Spezies und Herkunft

Origin Exprimiert in
Human ,
Rat (Rattus)

Weitere Proteine zu Collagen, Type III (COL3) Interaktionspartnern

Human Collagen, Type III (COL3) Interaktionspartner

  1. Thrombin generation increases between the up- and downregulation phases of In Vitro Fertilization (IVF). No correlation between thrombin generation and TFPI was shown during IVF.

  2. Elevated plasma levels of procoagulant factors, such as FVIII or prothrombin, enhanced thrombin generation and reduced the amount of TF required for the initiation of thrombin formation.

  3. When endothelial cells are incubated with antiphospholipid antibodies thrombin generation is increased.

  4. No significant difference in FVL genotype between patients and controls was observed, whereas high frequencies of PRT G20210A, MTHFR C677T and MTHFR A1298C mutations in the Hb S patients

  5. This study proved that Berberine (BBR) is a direct thrombin inhibitor that has activity in inhibiting thrombin-induced platelet aggregation. BBR may be a potential candidate for the development of safe and effective thrombin-inhibiting drugs

  6. Thrombin generation had a limited impact as biomarker of venous thromboembolism.

  7. results explain the reduced pro-coagulant activity of the W215A mutant and demonstrate the allosteric connection between Trp215, the sodium-binding loop, and the active site

  8. Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.

  9. the prothrombotic activity of FII is the result of a polymorphism and of a missense mutation, whereas that of FV derives only from a polymorphism. The observation that a clotting factor defect may be associated with both bleeding or venous thrombosis depending on the site of the mutation has caused an extensive reevaluation of the blood clotting mechanism.

  10. Findings provide evidence for a relationship between two genes-three mutations-of the cardiovascular disease (CVD genes panel and recurrent pregnancy loss (RPL). These genotypes include the heterozygous state of the factor II G20210A mutation.

  11. digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns.

  12. Prothrombin gene mutation is rare in Budd-Chiari syndrome patients in India.

  13. In HBV-related cirrhosis, the combination of miR-122, AFP and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.

  14. Data, including data using network analysis, suggest that angiotensinogen (AGT), mitogen-activated protein kinase-14 (MAPK14), and prothrombin (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.

  15. Arg596Gln mutation is a risk factor for Chinese patients with venous thromboembolism due to its moderately decreased clotting activity but strong resistance to antithrombin inhibition.

  16. The induction of TG by BXPC3 cells was mainly driven by the TF pathway while TG generation triggered by MCF7 cells was also driven by FXII activation.

  17. we were not able to confirm the association between the polymorphisms of f5, f2, and mthfr and pregnancy loss in Bosnian women

  18. Platelets were activated in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients, and such activation was at least partially attributed to the thrombin-protease-activated receptors (PARs) pathway.

  19. The meta-analysis enabled us to underline the importance of DCP in the refinement of the eligibility criteria of hepatocellular cancer (HCC)patients for liver transplant (LT). This information, based on Japanese studies performed in the setting of living-donor LT only, needs further validation in the Western world both in the setting of post-mortem and living-donor LT.

  20. HCC [hepatocellular carcinoma] patients who are sero-positive for DCP [Des-gamma-carboxyprothrombin] and sero-negative for AFP[Alpha-fetoprotein] have significantly higher levels of serum ALT[alanine aminotransferase]; serum ALT levels may be of diagnostic importance in AFP-negative, HBV-related HCC [hepatitis B virus-related hepatocellular carcinoma] patients.

Mouse (Murine) Collagen, Type III (COL3) Interaktionspartner

  1. These results suggested that the thrombinstimulated synthesis of IL6 was limited by HSP90 in osteoblasts, and that the effects of HSP90 were exerted at the point between Rhokinase and p38 MAPK.

  2. Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.

  3. These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.

  4. mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.

  5. Biglycan plays a protective role during the progression of atherosclerosis in ApoE-deficient mice by inhibiting thrombin generation.

  6. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin

  7. thrombin/PAR-1 interaction regulated MCP-1, TF, MCSF and IL-6 production.

  8. Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin nanoparticle therapeutics.

  9. Thrombin-PAR1 signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC) mobilization.

  10. Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.

  11. Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.

  12. thrombin/PAR1 pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.

  13. High Factor IIa expression is associated with multiorgan pathologies in sickle cell disease.

  14. Blockage of thrombin exosites with compounds specific for exosite I (hirudin and HD1 aptamer) or exosite II (heparin and HD22 aptamer) impaired the COMP-thrombin interaction, indicating a 2-site binding mechanism.

  15. Whole blood thrombin generation assay is capable of detecting a prothrombotic phenotype in Bmal1-KO mice.

  16. Fyn, but not Lyn, was required for complete Pyk2 phosphorylation by thrombin.

  17. Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment.

  18. The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.

  19. Influenza virus H1N1 activates platelets through FcgammaRIIA signaling and thrombin generation.

  20. These results indicate that thrombin acts through multiple mechanisms to activate MMPs and PGE2 synthesis in amnion.

Collagen, Type III (COL3) Protein Überblick

Protein Überblick

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Genbezeichner und Symbole assoziert mit Collagen, Type III Proteine (COL3)

  • coagulation factor II, thrombin (F2)
  • coagulation factor II (F2)
  • Cf-2 Protein
  • Cf2 Protein
  • FII Protein
  • prothrombin Protein
  • PT Protein
  • RPRGL2 Protein
  • THPH1 Protein
  • thrombin Protein

Bezeichner auf Proteinebene für Collagen, Type III Proteine (COL3)

prepro-coagulation factor II , prothrombin , prothrombin B-chain , serine protease , coagulation factor 2 , thrombin

GENE ID SPEZIES
2147 Homo sapiens
14061 Mus musculus
29251 Rattus norvegicus
395306 Gallus gallus
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