Collagen, Type II Proteine (COL2)

Human Collagen, Type II (COL2) Interaktionspartner

1. This study proved that Berberine (BBR) is a direct thrombin (zeige F2 Proteine) inhibitor that has activity in inhibiting thrombin (zeige F2 Proteine)-induced platelet aggregation. BBR may be a potential candidate for the development of safe and effective thrombin (zeige F2 Proteine)-inhibiting drugs

2. Thrombin (zeige F2 Proteine) generation had a limited impact as biomarker of venous thromboembolism.

3. Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.

4. the prothrombotic activity of FII is the result of a polymorphism and of a missense mutation, whereas that of FV derives only from a polymorphism. The observation that a clotting factor (zeige F7 Proteine) defect may be associated with both bleeding or venous thrombosis depending on the site of the mutation has caused an extensive reevaluation of the blood clotting mechanism.

5. Findings provide evidence for a relationship between two genes-three mutations-of the cardiovascular disease (CVD genes panel and recurrent pregnancy loss (RPL). These genotypes include the heterozygous state of the factor II G20210A mutation.

6. digestion of thrombin (zeige F2 Proteine) by P. aeruginosa elastase leads to the release of the C-terminal thrombin (zeige F2 Proteine)-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns.

7. Prothrombin (zeige F2 Proteine) gene mutation is rare in Budd-Chiari syndrome patients in India.

8. In HBV-related cirrhosis, the combination of miR (zeige MLXIP Proteine)-122, AFP (zeige AFP Proteine) and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.

9. Data, including data using network analysis, suggest that angiotensinogen (AGT (zeige AGT Proteine)), mitogen-activated protein kinase-14 (MAPK14 (zeige MAPK14 Proteine)), and prothrombin (zeige F2 Proteine) (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.

10. Arg596Gln mutation is a risk factor for Chinese patients with venous thromboembolism due to its moderately decreased clotting activity but strong resistance to antithrombin (zeige SERPINC1 Proteine) inhibition.

Mouse (Murine) Collagen, Type II (COL2) Interaktionspartner

1. These results suggested that the thrombinstimulated synthesis of IL6 (zeige IL6 Proteine) was limited by HSP90 (zeige HSP90 Proteine) in osteoblasts, and that the effects of HSP90 (zeige HSP90 Proteine) were exerted at the point between Rhokinase and p38 MAPK (zeige MAPK14 Proteine).

2. Platelet derived microparticles formed in sepsis are a potent inducer of thrombin (zeige F2 Proteine) generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.

3. These findings imply that a thrombin (zeige F2 Proteine)-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.

4. mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin (zeige F2 Proteine) carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.

5. Biglycan (zeige BGN Proteine) plays a protective role during the progression of atherosclerosis in ApoE (zeige APOE Proteine)-deficient mice by inhibiting thrombin (zeige F2 Proteine) generation.

6. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (zeige GP1BA Proteine)-binding and heparin-binding site of thrombin (zeige F2 Proteine)

7. thrombin (zeige F2 Proteine)/PAR-1 (zeige MARK2 Proteine) interaction regulated MCP-1 (zeige CPT1B Proteine), TF, MCSF (zeige CSF1 Proteine) and IL-6 (zeige IL6 Proteine) production.

8. Observations illustrate the role of thrombin (zeige F2 Proteine) as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (zeige SERPINC1 Proteine) nanoparticle therapeutics.

9. Thrombin (zeige F2 Proteine)-PAR1 (zeige F2R Proteine) signaling, via nitric oxide and EPCR (zeige PROCR Proteine), promotes hematopoietic stem cell (HSC (zeige FUT1 Proteine)) mobilization.

10. Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.

Cow (Bovine) Collagen, Type II (COL2) Interaktionspartner

1. the weaker rapid interaction between prothrombin (zeige F2 Proteine) and membranes is the most important in vivo when considering the activation of prothrombin (zeige F2 Proteine) at the cell surface.

2. novel pyranosic sulfated (zeige SULF1 Proteine) arabinan Ab1 exerts its anticoagulant activity on thrombin (zeige F2 Proteine) by a mechanism different from those found previously for other sulfated (zeige SULF1 Proteine) polysaccharides and glycosaminoglycans

3. Exogenous delivery of thrombin (zeige F2 Proteine) enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.

4. the signaling pathways of MAPK (zeige MAPK1 Proteine), MSK1 (zeige RPS6KA5 Proteine), and NF-kappaB (zeige NFKB1 Proteine) play important roles in thrombin (zeige F2 Proteine)-induced iNOS (zeige NOS2 Proteine) expression in alveolar macrophages

5. High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.

6. Thrombin (zeige F2 Proteine) induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (zeige F2R Proteine)) and thereby increasing the sensitivity of the myofilament to Ca(2 (zeige CA2 Proteine)+).

7. kinetic and structural analysis of interactions between thrombin (zeige F2 Proteine) and the Factor XIII (zeige UGDH Proteine) activation peptide

8. analysis of staphylocoagulase-mediated bovine prothrombin (zeige F2 Proteine) activation

9. thrombin (zeige F2 Proteine) and factor Xa (zeige F10 Proteine) diffusion along the heparin molecule explains the effects of extended heparin chain lengths

10. A comparison of recombinant thrombin (zeige F2 Proteine) to bovine thrombin (zeige F2 Proteine) as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.