anti-Coagulation Factor VIII (F8) Antikörper

Zebrafish Coagulation Factor VIII (F8) Interaktionspartner

1. gene is flanked by factor VII (zeige TH Antikörper) and factor X genes; gene encodes a protein homologous to factor VII (zeige TH Antikörper), but lacks critical residues for factor VII (zeige TH Antikörper) activity; functions as an inhibitor of blood coagulation in biochemical assays using zebrafish or human plasmas

Mouse (Murine) Coagulation Factor VIII (F8) Interaktionspartner

1. Cytokine release was quantified from FVIII(-/-) splenocytes restimulated with FVIII in the absence or presence of different anti-FcgammaRIIB (CD32) Antibodies (anti-CD32 mAbs) over 6 days.

2. results revealed localized vascular expression of FVIII and von Willebrand factor (zeige VWF Antikörper) and identified lymphatic endothelial cell as a major cellular source of FVIII in extrahepatic tissues.

3. the results indicate that residues in the C1 and/or C2 domains of factor VIII are implicated in immunogenic factor VIII uptake, at least in vitro Conversely, in vivo, the binding to endogenous von Willebrand factor (zeige VWF Antikörper) masks the reducing effect of mutations in the C domains on factor VIII immunogenicity.

4. data demonstrate that infusion of platelets containing FVIII triggers neither primary nor memory anti-FVIII immune response in FVIII(null) mice

5. Both platelet-VWF (zeige VWF Antikörper) and plasma-VWF (zeige VWF Antikörper) are required for optimal platelet-derived FVIII gene therapy for hemophilia A in the presence of inhibitors.

6. These data support the investigation of FVIII orthologs as treatment modalities in both the congenital and acquired FVIII inhibitor settings.

7. Activatable bioengineered FIX molecules with FVIII-independent activity might be a promising tool for improving hemophilia A treatment, especially for patients with inhibitors.

8. This study demonstrated that FVIIIa interacts with Low-density lipoprotein receptor-related protein 1 (zeige LRP1 Antikörper) cluster III.

9. a fragment containing only approximately 20% of the VWF (zeige VWF Antikörper) sequence is sufficient to support FVIII stability in vivo

10. Endothelial cells from multiple, but not all, tissues contribute to the plasma FVIII pool in the mouse.

Human Coagulation Factor VIII (F8) Interaktionspartner

1. Report a diagnostic algorithm that can reliably identify pathogenic variants of factor 8/9 and von Willebrand factor (zeige VWF Antikörper) and diagnose patients with hemophilia A, hemophilia B or von Willebrand disease.

2. Each hFVIII vector was administered to FVIII knockout (KO) mice at a dose of 10(10) genome copies (GC) per mouse. Criteria for distinguishing the performance of the different enhancer/promoter combinations were established prior to the initiation of the studies.

3. Relevance of ethnic differences in factor XIII (zeige UGDH Antikörper) activity on laboratory reference ranges.

4. analysis of co-existing variants in both F8 and PTGS-1 (zeige PTGS1 Antikörper) genes in a three-generation pedigree of hemophilia A

5. FVIII endocytosis is driven by interaction with LRP1 (zeige LRP1 Antikörper)

6. A coagulation initiating pathway is revealed in which the TF-FVIIa-nascent FXa (zeige F10 Antikörper) complex activates FVIII apart from thrombin (zeige F2 Antikörper) feedback.

7. An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII by thrombin (zeige F2 Antikörper) has been presented.

8. Of special importance is the sequential formation of disulfide bonds with different functions in structural support of VWF (zeige VWF Antikörper) multimers, which are packaged, stored and further processed after secretion. Here, all these processes are being reviewed in detail including background information on the occurring biochemical reactions. [review]

9. The FVIII C1 domain contributes significantly to the immune response against FVIII in acquired and congenital hemophilia inhibitor patients.

10. the existing epidemiologic investigations with an overview of the range of possible biochemical and immunologic mechanisms that may contribute to the different immune outcomes observed with plasma-derived and recombinant FVIII products.

Pig (Porcine) Coagulation Factor VIII (F8) Interaktionspartner

1. It was concluded that VEGF (zeige VEGFA Antikörper) and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.

2. thrombin (zeige F2 Antikörper) stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (zeige UGDH Antikörper) and by receptor-mediated up-regulation of factor XIII (zeige UGDH Antikörper) synthesis

3. cupredoxin-like A1 subdomains in fVIII contain inter-species differences that are a result of selective pressure on the dissociation rate constant

Cow (Bovine) Coagulation Factor VIII (F8) Interaktionspartner

1. Factor VIIIc (zeige COX7A2 Antikörper) is responsible for tissue invasion during tumor progression.