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CD1e encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin.
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There was no association between polymorphisms of CD1E genes and the susceptibilities to Guillain-Barre syndrome.
for isoforms CD1b (zeige CD1B Antikörper) through CD1e, our simulations show the near-complete collapse of the hydrophobic cavities in the absence of the antigen. This event results from the spontaneous closure of the binding domain entrance, flanked by two alpha-helices.
The interaction of LAPTM5 (zeige LAPTM5 Antikörper) with CD1e and their colocalization in antigen processing compartments both suggest that LAPTM5 (zeige LAPTM5 Antikörper) might influence the role of CD1e in the presentation of lipid antigens.
Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo (zeige SYNPO2 Antikörper)-inositol mannosides (PIM (zeige PIM1 Antikörper)) processing for presentation by CD1b (zeige CD1B Antikörper) to T lymphocytes
in the late endosomes/lysosomes of dendritic cells, the acid pH promotes the binding of lipid antigens to CD1e through increased hydrophobic and ionic interactions
allelic variation in CD1E does not play a major role in determining multifocal motor neuropathy susceptibility.
In Guillain-Barre syndrome, an initially positive association study with polymorphism of CD1A (zeige CD1A Antikörper) and CD1E genes was not confirmed
CD1e may positively or negatively affect lipid presentation by CD1b (zeige CD1B Antikörper), CD1c (zeige CD1C Antikörper), and CD1d (zeige CD1D Antikörper).
These data support that CD1e could have evolved to mediate lipid-exchange/editing processes.
CD1A (zeige CD1A Antikörper) and CD1E polymorphisms contribute to the polygenic susceptibility to multiple sclerosis
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found\; however, their biological validity has not been determined.
CD1E antigen, e polypeptide
, T-cell surface glycoprotein CD1e, membrane-associated
, differentiation antigen CD1-alpha-3
, leukocyte differentiation antigen
, thymocyte antigen CD1E
, T-cell surface glycoprotein CD1e, soluble