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Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. Zusätzlich bieten wir Ihnen Cleavage and Polyadenylation Specific Factor 1, 160kDa Kits (5) und Cleavage and Polyadenylation Specific Factor 1, 160kDa Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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cpsf1 is essential for hematopoietic stem cell survival and differentiation in caudal hematopoietic tissue
Knockdown of CPSF inhibits the proliferation, migration and invasion of ovarian carcinoma cells.
The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation.
CPSF1 was identified among protein-binding candidates. A consensus polyadenylation signal AAUAAA is present in intron 6 of IL7 receptor directly downstream from the 5' splice site. Mutations to this site and CPSF1 knockdown increased exon 6 inclusion.
Data report that PABPN1 is required to restrict CPSF binding to the AAUAAA sequence and to permit the stimulation of poly(A) polymerase by AAUAAA-bound CPSF to be maintained throughout the elongation reaction.
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995
cleavage and polyadenylation specificity factor subunit 1
, cleavage and polyadenylation specificity factor
, cleavage and polyadenylation specificity factor 160
, drosophila cleavage and polyadenylation stimulation factor-160
, cleavage and polyadenylation specific factor 1, 160kDa
, CPSF 160 kDa subunit
, cleavage and polyadenylation specificity factor 1
, cleavage and polyadenylation specificity factor 160 kDa subunit
, polyadenylation specificity factor