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CIRH1A encodes a WD40-repeat-containing protein that is localized to the nucleolus. Zusätzlich bieten wir Ihnen CIRH1A Antikörper (37) und und viele weitere Produktgruppen zu diesem Protein an.
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data provide the first in vivo evidence of a role for Cirhin in biliary development, and support the hypothesis that congenital defects affecting ribosome biogenesis can activate a cellular stress response mediated by p53
Results show that CIRH1A was highly expressed in carcinoma samples and colorectal cancer cells and suggest that CIRH1A plays a critical role in the proliferation, cell cycle distribution, and apoptosis of human malignant colorectal cells.
A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis
Cirhin is a nucleolar protein and the R565W mutation, for which all North American Indian childhood cirrhosis patients are homozygous, has no effect on subcellular localization.
Cirhin is a transcriptional regulatory factor of this NF-kappaB sequence and could be a participant in the regulation of other genes with NF-kappaB responsive elements.
This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence.
, testis-expressed gene 292
, cirrhosis, autosomal recessive 1A (cirhin)
, UTP4, small subunit (SSU) processome component, homolog
, testis expressed gene 292
, testis-expressed gene 292 protein