anti-Chromosome 6 Open Reading Frame 134 (C6orf134) Antikörper

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Zusätzlich bieten wir Ihnen Chromosome 6 Open Reading Frame 134 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
C6orf134 79969 Q5SQI0
C6orf134 73242 Q8K341
C6orf134 361789 Q6MG11
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Top anti-Chromosome 6 Open Reading Frame 134 Antikörper auf antikoerper-online.de

Showing 10 out of 33 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-C6orf134 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  293T cell lysate ATAT1 is supported by BioGPS gene expression data to be expressed in HEK293T 100 μL 2 bis 3 Tage
$319.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-C6orf134 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: ACHN cell lysate 100 μL 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
$507.83
Details
Hund Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
$581.17
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert WB C6ORF134 antibody used at 2.5 ug/ml to detect target protein. 100 μg 9 bis 11 Tage
$369.29
Details
Hund Kaninchen Unkonjugiert ELISA, WB 100 μL 2 bis 3 Tage
$446.88
Details
Human Kaninchen Unkonjugiert ELISA, WB 100 μL 2 bis 3 Tage
$446.88
Details
Human Kaninchen Unkonjugiert WB C6orf134 antibody used at 1 ug/ml to detect target protein. 50 μg 9 bis 11 Tage
$449.29
Details
Human Kaninchen Unkonjugiert WB C6ORF134 antibody used at 1 ug/ml to detect target protein. 50 μg 9 bis 11 Tage
$449.29
Details

Am meisten referenzierte anti-Chromosome 6 Open Reading Frame 134 Antikörper

  1. Cow (Bovine) Polyclonal C6orf134 Primary Antibody für WB - ABIN2775513 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 2 Pubmed References

  2. Cow (Bovine) Polyclonal C6orf134 Primary Antibody für WB - ABIN2775511 : Kalebic, Martinez, Perlas, Hublitz, Bilbao-Cortes, Fiedorczuk, Andolfo, Heppenstall: Tubulin acetyltransferase ?TAT1 destabilizes microtubules independently of its acetylation activity. in Molecular and cellular biology 2013 (PubMed)

Weitere Antikörper gegen Chromosome 6 Open Reading Frame 134 Interaktionspartner

Human Chromosome 6 Open Reading Frame 134 (C6orf134) Interaktionspartner

  1. the actin-MRTF-SRF circuit controls alpha-TAT1 transcription. INF2 regulates the circuit, and hence microtubule acetylation, in cell types where it has a prominent role in actin polymerization.

  2. The specific distributions of ATAT1 through the cell cycle in fibroblasts suggest multiple functions of ATAT1, which could include acetylation of microtubules, RNA transcription activity, severing microtubules, and completion of cytokinesis.

  3. these results demonstrate alphaTAT1 enters the lumen of microtubules from open extremities and spreads K40 acetylation marks longitudinally along cellular microtubules; this mode of tip-directed microtubule acetylation may allow for selective acetylation of subsets of microtubules

  4. Depletion of the tubulin acetyltransferase TAT1 led to a significant increase in the frequency of microtubule breakage.

  5. cellular quiescence induces Mec17 to couple the production of acetylated microtubules and Myh10, whose accumulation overcomes the inhibitory role of Myh9 and initiates ciliogenesis

  6. These results suggest that alphaTAT1-mediated Wnt1 expression via microtubule acetylation is important for colon cancer progression.

  7. Studies indicate that alpha-tubulin acetylation and microtubule level is mainly governed by opposing actions of alpha-tubulin acetyltransferase 1 (ATAT1) and histone deacetylase 6 (HDAC6).

  8. Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia.

  9. Data suggest that invariant residues Arg132 and Ser160 in catalytic domain of ATAT1 participate in stable interaction with CoA and acetyl-CoA; ATAT1 with mutation at either residue exhibits much faster intracellular degradation.

  10. Crystal structure of the catalytic core of human MEC-17 in complex with acetyl-CoA. MEC17 has large, conserved surface patch that is critical for enzymatic activity suggesting extensive interactions with alpha-tubulin.

  11. Mechanistic underpinnings for TAT activity and its preference for microtubules with slow turnover; cocrystal structures constrain TAT action to the microtubule lumen with Lys40 engaged in a suboptimal active site; despite the confined location of Lys40, TAT efficiently scans the microtubule bidirectionally and acetylates stochastically without preference for ends.

  12. microtubules contacting clathrin-coated pits become acetylated by alphaTAT1; in migrating cells, this mechanism ensures the acetylation of microtubules oriented towards the leading edge, thus promoting directional cell locomotion and chemotaxis

  13. cysteine residues play important catalytic roles through a ternary complex mechanism. alphaTAT1 mutations have analogous effects on tubulin acetylation in vitro and in cells

  14. analysis reveals a basic patch implicated in substrate binding and a conserved glutamine residue required for catalysis, demonstrating that the family of alpha-tubulin acetyltransferases uses a reaction mechanism different from other lysine acetyltransferases

Zebrafish Chromosome 6 Open Reading Frame 134 (C6orf134) Interaktionspartner

  1. Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus.

Mouse (Murine) Chromosome 6 Open Reading Frame 134 (C6orf134) Interaktionspartner

  1. ATAT1 found in regulating mouse forebrain development and governing tubulin hyperacetylation during stress responses, but also suggests the existence of an additional alpha-tubulin acetyltransferase.

  2. TAK1 directly interacts with and phosphorylates alphaTAT1 at Ser237 to critically enhance its catalytic activity.

  3. Atat1 knockdown resulted in a significant increase in the expression of ACTH-producing genes and decreased the dexamethasone-induced nuclear translocation of glucocorticoid receptor accompanied with a reduction in alpha-tubulin acetylation.

  4. Here the authors demonstrate that mice lacking the alpha-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli.

  5. alphaTAT1 has a conserved function as the major alpha-tubulin acetyltransferase in ciliated organisms and has an important role in regulating subcellular specialization of subsets of microtubules.

  6. Data indicate that alpha-tubulin acetyltransferase 1 Atat1 is not required for survival and development but may regulate more advanced functions.

  7. Acetylation of alpha-tubulin is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and HDAC6 (histone deacetylase 6). Adipocyte development is inhibited in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing cells.

Chromosome 6 Open Reading Frame 134 (C6orf134) Antigen-Profil

Protein Überblick

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development (By similarity).

Genbezeichner und Symbole assoziert mit C6orf134

  • alpha tubulin acetyltransferase 1 (ATAT1) Antikörper
  • alpha tubulin acetyltransferase 1 (atat1) Antikörper
  • alpha tubulin acetyltransferase 1 S homeolog (atat1.S) Antikörper
  • alpha tubulin acetyltransferase 1 (Atat1) Antikörper
  • 0610011P08Rik Antikörper
  • 2610008K08Rik Antikörper
  • 2610110G12Rik Antikörper
  • 3110080J08Rik Antikörper
  • Alpha-TAT Antikörper
  • C4H6orf134 Antikörper
  • c6orf134 Antikörper
  • C7H6ORF134 Antikörper
  • C23H6orf134 Antikörper
  • Mec17 Antikörper
  • Nbla00487 Antikörper
  • RGD1303066 Antikörper
  • TAT Antikörper
  • wu:fj19c03 Antikörper
  • zgc:65893 Antikörper
  • zgc:77443 Antikörper

Bezeichner auf Proteinebene für C6orf134

acetyltransferase mec-17 homolog , alpha-TAT , alpha-tubulin N-acetyltransferase , MEChanosensory abnormality homolog , Novel DUF738 containing protein (2610110G12Rik) , alpha-tubulin N-acetyltransferase 1

GENE ID SPEZIES
79969 Homo sapiens
406389 Danio rerio
735057 Xenopus laevis
786491 Bos taurus
73242 Mus musculus
361789 Rattus norvegicus
100144480 Sus scrofa
100141388 Macaca mulatta
100719818 Cavia porcellus
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