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CHGB encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. Zusätzlich bieten wir Ihnen CHGB Antikörper (50) und CHGB Proteine (17) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) CHGB ELISA Kit für Sandwich ELISA - ABIN649192
Fanara, Wong, Husted, Liu, Liu, Kohlstaedt, Riiff, Protasio, Boban, Killion, Killian, Epling, Sinclair, Peterson, Price, Cabin, Nussbaum, Brühmann, Brandt, Christine, Aminoff, Hellerstein: Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. in The Journal of clinical investigation 2012
Show all 2 Pubmed References
This analysis of mice lacking Cgs highlights the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Chromogranin B contributes to a highly efficient system that directly mediates monoamine accumulation and exocytosis in large dense core secretory vesicles.
C-terminal domain of chromogranin B regulates intracellular calcium signaling.
CgB is not required for normal insulin (zeige INS ELISA Kits) granule biogenesis or maintenance in vivo, but is essential for adequate secretion of islet hormones
Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles in mice.
CGB was localized in the nucleus; transcription control role of CGB in the nucleus
These data suggest that RAGE (zeige AGER ELISA Kits) signaling is capable of driving neuronal differentiation involving CREB (zeige CREB1 ELISA Kits) activation and induction of chromogranin expression.
Chromogranin B has a role in secretory granule biogenesis
CGB may play an important modulatory role in the control of Ca2 (zeige CA2 ELISA Kits)+ release from the endoplasmic reticulum
Neuroendocrine-specific expression of Chgb is mediated by the CRE and G/C boxes in cis (zeige CISH ELISA Kits) and the transcription factors CREB (zeige CREB1 ELISA Kits), AP-2 (zeige TFAP2A ELISA Kits), Egr-1 (zeige EGR1 ELISA Kits) and Sp1 (zeige SP1 ELISA Kits).
results presented here suggest that CHGB variant alleles, the rare CHGB-L413 and common CHGB-P413, may act as modifiers of ALS (zeige IGFALS ELISA Kits) disease dependent on their expression levels which is higher in females because of a sex-determining region Y (zeige SRY ELISA Kits) element in the CHGB gene promoter.
Compared with chromogranin A (zeige CHGA ELISA Kits), chromogranin B may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study.
Data indicate that measurement of chromogranin A (CgA (zeige CHGA ELISA Kits)) alone is sufficient in the management of patients with neuroendocrine tumours (NETs) and that routine additional measurement of chromogranin B (CgB) provides little added value.
intracellular calcium binding protein (zeige CETN1 ELISA Kits) Sg1 (zeige ZNF750 ELISA Kits) is increased in early multiple sclerosis (MS) patients compared to relapsing-remitting MS and neurological controls.
The polymorphism P413L in the CHGB gene was not associated with sporadic amyotrophic lateral sclerosis in a group of Italian patients.
CgA (zeige CGA ELISA Kits) and CgB (zeige CGB ELISA Kits) have been used as general NEN biomarkers for many years, while CART has only recently been identified
A heterogeneous response to short- and long-term physical activities among circulating granin proteins, particularly chromogranin B.
CgA (zeige CGA ELISA Kits), CgB (zeige CGB ELISA Kits), and secretoneurin (zeige SCG2 ELISA Kits) are detectable in feces, and collagenous colitis patients express higher values than patients with inflammatory bowel disease and controls. In treatment, fecal secretoneurin (zeige SCG2 ELISA Kits) decreased to control levels in collagenous colitis.
Our findings suggest that altered PTEN, ATRX (zeige ATRX ELISA Kits), CHGA (zeige CHGA ELISA Kits), and CHGB expression are associated with aggressive PNET phenotype in VHL (zeige VHL ELISA Kits) and may serve as useful adjunct prognostic markers to Ki-67 (zeige MKI67 ELISA Kits) in PNETs.
chromogranin B has a role in the IP(3)-mediated Ca(2 (zeige CA2 ELISA Kits)+) release mechanism of secretory granules
colocalization of all three inositol 1,4,5-trisphosphate receptor (IP(3)R (zeige ITPR1 ELISA Kits))isoforms with chromogranin B to the extent that the majority of each IP(3)R (zeige ITPR1 ELISA Kits) isoform-labeling gold particles found in the nucleoplasm
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2 (zeige CA2 ELISA Kits)+) homeostasis in secretory cells
Chromogranin B was found to co-localize with secretogranin II (zeige SCG2 ELISA Kits) and IP3 receptors in the nucleus, more specifically, in the IP3-sensitive nucleoplasmic Ca2 (zeige CA2 ELISA Kits)+ store vesicles.
expression and localization of chromogranin A (CgA (zeige CHGA ELISA Kits)), chromogranin B (CgB), synaptophysin (zeige SYP ELISA Kits), and insulin (zeige INS ELISA Kits) were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides.
, secretogranin I
, secretogranin B
, Chromogranin B, parathyroid secretory protein
, glucagonoma peptide