anti-Chromodomain Helicase DNA Binding Protein 5 (CHD5) Antikörper

Human Chromodomain Helicase DNA Binding Protein 5 (CHD5) Interaktionspartner

1. CHD5 (zeige WRB Antikörper) was identified as a direct target of miR (zeige MLXIP Antikörper)-454. CHD5 (zeige WRB Antikörper) was downregulated in GC tissues/cell lines and the expresssion of CHD5 (zeige WRB Antikörper) inversely correlated with the level of miR (zeige MLXIP Antikörper)-454 in GC tissues. Taken together, these observations indicate that HDAC3 (zeige HDAC3 Antikörper) is associated with GC cell growth via the miR (zeige MLXIP Antikörper)-454-mediated targeting of CHD5 (zeige WRB Antikörper).

2. Data show that chromodomain helicase DNA binding protein 5 (CHD5) acted as a functional tumor suppressor and was frequently silenced by promoter CpG methylation in renal cell carcinoma (zeige MOK Antikörper) (RCC (zeige XRCC1 Antikörper)).

3. CHD5 (zeige WRB Antikörper) may act as a tumor suppressor gene in NSCLC.

4. Authors identified the CHD5 (zeige WRB Antikörper) as a direct target of miR (zeige MLXIP Antikörper)-454. CHD5 (zeige WRB Antikörper) was downregulated in HCC (zeige FAM126A Antikörper) tissues and cell lines and the expression level of CHD5 (zeige WRB Antikörper) was inversely correlated with the expression of miR (zeige MLXIP Antikörper)-454 in HCC (zeige FAM126A Antikörper) tissues.

5. Data show a mutual suppression regulation between chromodomain helicase DNA binding protein 5 (CHD5) and enhancer of zeste homolog 2 (EZH2 (zeige EZH2 Antikörper), which may provide new insights into their potential therapeutic significance for hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)).

6. CHD5 (zeige WRB Antikörper) methylation of rectal cancer has a great effect in influencing its clinical and pathological features.

7. Study shows that CHD5 (zeige WRB Antikörper) is a Nucleosome remodeling and deacetylase complex-associated transcriptional repressor and identifies WEE1 (zeige WEE1 Antikörper) as one of the CHD5 (zeige WRB Antikörper)-regulated genes that may link CHD5 (zeige WRB Antikörper) to tumor suppression.

8. Low CHD5 (zeige WRB Antikörper) expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer.

9. CHD5 (zeige WRB Antikörper) is a potential tumour suppressor gene epigenetically silenced in hepatocellular carcinoma.

10. The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping.

Mouse (Murine) Chromodomain Helicase DNA Binding Protein 5 (CHD5) Interaktionspartner

1. Pyramidal neurons cultured from Chd5 (zeige WRB Antikörper)(-/-) cortex displayed alterations in dendritic morphology. Paralleling autism spectrum disorder nosology, Chd5 (zeige WRB Antikörper)(-/-) mice exhibited abnormal sociocommunicative behavior and a strong preference for familiarity. Chd5 (zeige WRB Antikörper)(-/-) mice further showed deficits in responding to the distress of a conspecific, a mouse homolog of empathy.

2. Chd5 represses murine endogenous retrovirus-L (MuERV-L/MERVL), an endogenous retrovirus-derived retrotransposon, by regulating H3K27me3 and H3.1/H3.2 function.

3. Chd5 (zeige WRB Antikörper) is a multi-faceted mediator of histone-to-protamine replacement and is important in the cascade of molecular events underlying this process of extensive chromatin remodelling.

4. Our data indicate that CHD5 (zeige WRB Antikörper) is required for normal spermiogenesis, especially for spermatid chromatin condensation.

5. Chd5 (zeige WRB Antikörper) expression is retained at high levels in differentiated neurons of the adult mouse.

6. These findings provide insights into the regulatory role of CHD5 (zeige WRB Antikörper) during neurogenesis and suggest how inactivation of this candidate tumor suppressor might contribute to neuroblastoma (zeige ARHGEF16 Antikörper).

7. Chd5 (zeige WRB Antikörper) binds the unmodified N terminus of H3 through its tandem plant homeodomains (PHDs).

8. CHD5 (zeige WRB Antikörper) regulates expression of neuronal genes, cell cycle genes and remodeling genes, and is linked to regulation of genes implicated in aging and Alzheimer's disease.

9. the association of between miR (zeige MLXIP Antikörper)-211-regulated CHD5 (zeige WRB Antikörper) expression and CHD5 (zeige WRB Antikörper) function in colorectal tumorigenesis