anti-Chromobox Homolog 8 (CBX8) Antikörper

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Zusätzlich bieten wir Ihnen CBX8 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CBX8 30951 Q9QXV1
CBX8 57332 Q9HC52
CBX8 303731  
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Top anti-CBX8 Antikörper auf antikoerper-online.de

Showing 10 out of 151 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-CBX8 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-CBX8 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  COLO205 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert ELISA, WB ABIN334369 (0.1µg/ml) staining of K562 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-CBX8 Antibody Titration:  2.5ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert EIA, WB CBX8 Antibody (Center) western blot analysis in mouse liver tissue lysates (35µg/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: Cbx8 Antibody [NBP1-83224] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY412158) Immunocytochemistry/Immunofluorescence: Cbx8 Antibody [NBP1-83224] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Maus Unkonjugiert ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using CBX8 mAb against human CBX8 recombinant protein. (Expected MW is 49.5 kDa) Dilution: 1/500 - 1/2000 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$577.50
Details
Human Maus Unkonjugiert IHC, IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$507.83
Details
Human Maus Unkonjugiert ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using CBX8 mAb against human CBX8 recombinant protein. (Expected MW is 49.5 kDa) Dilution: 1/500 - 1/2000 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$577.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB The anti-CBX8 C-term Pab (ABIN389089) is used in Western blot to detect CBX8 in mouse kidney tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details

Am meisten referenzierte anti-CBX8 Antikörper

  1. Human Polyclonal CBX8 Primary Antibody für IHC (p), ELISA - ABIN545281 : Bárdos, Saurin, Tissot, Duprez, Freemont: HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal CBX8 Primary Antibody für IP, WB - ABIN258057 : Maertens, El Messaoudi-Aubert, Elderkin, Hiom, Peters: Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. in The EMBO journal 2010 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal CBX8 Primary Antibody für FACS, ELISA - ABIN1724765 : Dietrich, Bracken, Trinh, Schjerling, Koseki, Rappsilber, Helin, Hansen: Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. in The EMBO journal 2007 (PubMed)

Weitere Antikörper gegen CBX8 Interaktionspartner

Mouse (Murine) Chromobox Homolog 8 (CBX8) Interaktionspartner

  1. Cbx8 associates with non-PRC1 complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch gene expression.

  2. CBX8 plates roles in epigenetic regulation in DNA damage response.

  3. Cbx8 is upregulated and recruited to activated genes during embryonic stem cell differentiation.

  4. CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis.

  5. Pcl2-PRC2 facilitates both PRC2 recruitment to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells.

  6. Huntingtin is a novel stimulator of polycomb repressive complex 2.

Human Chromobox Homolog 8 (CBX8) Interaktionspartner

  1. Circular RNA circ_0005230 was proved to be a sponge of miR-618, and expression of miR-618 could regulate CBX8 expression via targeting the 3'UTR of CBX8.

  2. CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/beta-catenin pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma.

  3. CBX8 binds with the Snai1 promoter, represses Snai1 transcription and suppresses esophageal carcinoma metastasis.

  4. The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients.

  5. CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1-BCOR complex at BCL6 binding sites to specifically silence genes in the germinal center and promote lymphomagenesis

  6. CBX8 plates roles in epigenetic regulation in DNA damage response.

  7. IGF1 can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression

  8. The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues.

  9. These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment.

  10. Low CBX8 expression was associated with distant metastasis in colorectal cancer.

  11. CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy.

  12. The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.

  13. Interaction with CBX8 precludes AF9-DOT1L binding.

  14. CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA. Upon ectopic expression, CBX8 or SIRT1 repressed the expression of p21(WAF1) by inhibiting p53 binding to the promoter.

  15. CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis.

  16. CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions.

CBX8 Antigen-Profil

Protein Überblick

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Genbezeichner und Symbole assoziert mit CBX8

  • chromobox 8 (cbx8) Antikörper
  • chromobox 8 (CBX8) Antikörper
  • chromobox 8 (Cbx8) Antikörper
  • chromobox 8 S homeolog (cbx8.S) Antikörper
  • chromobox homolog 8a (Pc class homolog, Drosophila) (cbx8a) Antikörper
  • cbx8 Antikörper
  • MGC147589 Antikörper
  • PC3 Antikörper
  • RC1 Antikörper

Bezeichner auf Proteinebene für CBX8

chromobox homolog 8 , chromobox protein homolog 8 , mPc3 , polycomb 3 homolog , Pc class 3 homolog , chromobox homolog 8 (Pc class homolog, Drosophila) , polycomb 3 , rectachrome 1 , chromobox-like protein 8 , chromobox homolog 8 (Pc class homolog) , chromobox homolog 8a

GENE ID SPEZIES
779897 Xenopus (Silurana) tropicalis
100604409 Nomascus leucogenys
30951 Mus musculus
57332 Homo sapiens
608591 Canis lupus familiaris
506458 Bos taurus
303731 Rattus norvegicus
496172 Xenopus laevis
100514536 Sus scrofa
422084 Gallus gallus
100150672 Danio rerio
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