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Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Zusätzlich bieten wir Ihnen CBX8 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CBX8 Primary Antibody für IHC (p), ELISA - ABIN545281
Bárdos, Saurin, Tissot, Duprez, Freemont: HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. in The Journal of biological chemistry 2000
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Human Polyclonal CBX8 Primary Antibody für IP, WB - ABIN258057
Maertens, El Messaoudi-Aubert, Elderkin, Hiom, Peters: Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. in The EMBO journal 2010
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Human Monoclonal CBX8 Primary Antibody für FACS, ELISA - ABIN1724765
Dietrich, Bracken, Trinh, Schjerling, Koseki, Rappsilber, Helin, Hansen: Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. in The EMBO journal 2007
Cbx8 associates with non-PRC1 complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch gene expression.
CBX8 plates roles in epigenetic regulation in DNA damage response.
Cbx8 is upregulated and recruited to activated genes during embryonic stem cell differentiation.
CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis.
Pcl2-PRC2 facilitates both PRC2 recruitment to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells.
Huntingtin is a novel stimulator of polycomb repressive complex 2.
Circular RNA circ_0005230 was proved to be a sponge of miR-618, and expression of miR-618 could regulate CBX8 expression via targeting the 3'UTR of CBX8.
CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/beta-catenin pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma.
CBX8 binds with the Snai1 promoter, represses Snai1 transcription and suppresses esophageal carcinoma metastasis.
The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients.
CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1-BCOR complex at BCL6 binding sites to specifically silence genes in the germinal center and promote lymphomagenesis
IGF1 can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression
The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues.
These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment.
Low CBX8 expression was associated with distant metastasis in colorectal cancer.
CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy.
The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.
Interaction with CBX8 precludes AF9-DOT1L binding.
CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA. Upon ectopic expression, CBX8 or SIRT1 repressed the expression of p21(WAF1) by inhibiting p53 binding to the promoter.
CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions.
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
chromobox homolog 8
, chromobox protein homolog 8
, polycomb 3 homolog
, Pc class 3 homolog
, chromobox homolog 8 (Pc class homolog, Drosophila)
, polycomb 3
, rectachrome 1
, chromobox-like protein 8
, chromobox homolog 8 (Pc class homolog)
, chromobox homolog 8a