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Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Zusätzlich bieten wir Ihnen CBX8 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CBX8 Primary Antibody für IP, WB - ABIN258057
Maertens, El Messaoudi-Aubert, Elderkin, Hiom, Peters: Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. in The EMBO journal 2010
Show all 2 Pubmed References
Human Monoclonal CBX8 Primary Antibody für FACS, ELISA - ABIN1724766
Dietrich, Bracken, Trinh, Schjerling, Koseki, Rappsilber, Helin, Hansen: Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. in The EMBO journal 2007
Cbx8 associates with non-PRC1 (zeige PRC1 Antikörper) complexes containing the H3K4 methyltransferase complex component WDR5 (zeige WDR5 Antikörper), which together regulate Notch (zeige NOTCH1 Antikörper) gene expression.
CBX8 plates roles in epigenetic regulation in DNA damage response.
Cbx8 is upregulated and recruited to activated genes during embryonic stem cell differentiation.
CBX8 plays an essential role in MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) transcriptional regulation and leukemogenesis.
Pcl2 (zeige MTF2 Antikörper)-PRC2 facilitates both PRC2 recruitment to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells.
Huntingtin (zeige HTT Antikörper) is a novel stimulator of polycomb (zeige CBX2 Antikörper) repressive complex 2.
CBX8 functions as an oncogene (zeige RAB1A Antikörper) to upregulate EGR1 (zeige EGR1 Antikörper) and miR (zeige MLXIP Antikörper)-365-3p to stimulate the AKT (zeige AKT1 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma.
CBX8 binds with the Snai1 (zeige SNAI1 Antikörper) promoter, represses Snai1 (zeige SNAI1 Antikörper) transcription and suppresses esophageal carcinoma metastasis.
The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 (zeige TP53 Antikörper) pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients.
CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1 (zeige PRC1 Antikörper)-BCOR (zeige BCOR Antikörper) complex at BCL6 (zeige BCL6 Antikörper) binding sites to specifically silence genes in the germinal center and promote lymphomagenesis
IGF1 (zeige IGF1 Antikörper) can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression
The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues.
These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment.
Low CBX8 expression was associated with distant metastasis in colorectal cancer.
CBX8 might emerge as an oncogene (zeige RAB1A Antikörper) for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy.
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
chromobox homolog 8
, chromobox protein homolog 8
, polycomb 3 homolog
, Pc class 3 homolog
, chromobox homolog 8 (Pc class homolog, Drosophila)
, polycomb 3
, rectachrome 1
, chromobox-like protein 8
, chromobox homolog 8 (Pc class homolog)
, chromobox homolog 8a