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The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway.
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Human Polyclonal Choline Kinase alpha Primary Antibody für ELISA, WB - ABIN560360
Vanpouille, Le Jeune, Kryza, Clotagatide, Janier, Dubois, Perek: Influence of multidrug resistance on (18)F-FCH cellular uptake in a glioblastoma model. in European journal of nuclear medicine and molecular imaging 2009
This study presents the detail the 2.35 A structure of choline kinase alpha in complex with inhibitor TCD (zeige CHM Antikörper)-717.
Results indicate that choline kinase alpha (CHKA) contributes to tumor progression and metastasis and may serve as a prognostic biomarker and potential therapeutic target in colorectal carcinoma (CRC (zeige CALR Antikörper)).
We found levels of CHKA to be increased in human HCCs (zeige HCCS Antikörper) compared to nontumor tissues, and increased expression to be associated with tumor aggressiveness. Overexpression of CHKA in HCC (zeige FAM126A Antikörper) cell lines increased their invasiveness, resistance to EGFR (zeige EGFR Antikörper) inhibitors, and ability to form metastatic tumors in mice by promoting interaction of EGFR (zeige EGFR Antikörper) with mechanistic target of rapamycin (zeige FRAP1 Antikörper) complex 2.
Study shows increased CHKA expression in pancreatic ductal adenocarcinoma tumors and may be a predictive marker of response to chemotherapy.
These data also support the approach of antitumor strategies that destabilize Chk-alpha protein or downregulate PtdCho in breast cancer treatment.
Downregulation of choline kinase-alpha enhances autophagy in tamoxifen-resistant breast cancer cells.
CHKA can act as an AR chaperone, providing, to our knowledge, the first evidence for kinases as molecular chaperones, making CHKA both a marker of tumor progression and a potential therapeutic target for PCa (zeige FLVCR1 Antikörper).
Identify choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.
choline kinase alpha is inhibited by a near-infrared fluorescent carbocyanine
Increased expression of CHKA is seen in malignant lesions of prostate cancer
hepatic phosphatidylcholine (zeige SGMS2 Antikörper) is regulated by the circadian clock through a Bmal1 (zeige ARNTL Antikörper)-Rev-erbalpha (zeige NR1D1 Antikörper)-Chkalpha axis
Enforced expression of either CK(alpha) or CCTalpha (zeige PCYT1A Antikörper) increased the rate of synthesis and the amount of PtdCho, and these cells initiated neuronal differentiation.
Lack of muscle degeneration in forelimbs of Chkb (zeige CHKB Antikörper)(-/-) mice is due to abundant choline kinase alpha and the stable homeostasis of phosphatidylcholine (zeige SGMS2 Antikörper).
Experimental evidence for the presence of heteromeric ChoK/EtnK in any source. The activity of ChoK/EtnK in the cell is controlled not only by the level of each isoform but also by their combination to form the active oligomer complex.
ChoK may have a role in carcinogenesis
Data suggest that the choline kinase alpha promoter has a distal element (-875/-867) that binds c-jun (zeige JUN Antikörper) and the binding of c-jun (zeige JUN Antikörper) is enhanced by treatment with CCl4 (zeige CCL4 Antikörper).
Chka is an essential gene for early embryonic development, but adult mice do not require full expression of the gene for normal levels of phosphatidylcholine (zeige SGMS2 Antikörper).
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.
choline kinase alpha
, choline kinase beta
, choline kinase
, ethanolamine kinase
, choline/ethanolamine kinase alpha
, choline kinase R