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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume.
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CLIC4 and Ihh (zeige IHH ELISA Kits) could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma.
in malignant pleural mesothelioma, the gene expressions of CLIC3 and CLIC4 were significantly increased compared to controls
CLIC1 (zeige CLIC1 ELISA Kits) and CLIC4 are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review)
CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility.
CLIC4, ERp29, and Smac/DIABLO (zeige DIABLO ELISA Kits) integrated into a novel panel based on cancer stem-like cells in association with metastasis stratify the prognostic risks of colorectal cancer.
This study investigated the proteome modulated by oncogenic KRAS in immortalized airway epithelial cells.
Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension.
CLIC4 increases tumor cell migration and invasion in a TGF-beta (zeige TGFB1 ELISA Kits)-dependent manner.
In addition to CLIC1 (zeige CLIC1 ELISA Kits) and TPM1 (zeige TPM1 ELISA Kits), which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2 (zeige TPM2 ELISA Kits), TPM3 (zeige TPM3 ELISA Kits), and TPM4 (zeige TPM4 ELISA Kits) were present in ovarian cancer patient sera at significantly elevated levels compared with controls.
Our data indicate that CLIC4 protein may be a key element in the apoptotic response to oxidative stress.
Results demonstrate that down-regulating CLIC4 inhibit the proliferation and promotes the apoptosis of mouse liver cancer Hca-F cell.
Results indicate CLICs (CLIC1 (zeige CLIC1 ELISA Kits), CLIC4 and CLIC5 (zeige CLIC5 ELISA Kits))-dependent chloride efflux as an essential and proximal upstream event for NLRP3 (zeige NLRP3 ELISA Kits) activation.
Data, including data from studies in primary cells from knockout mice, suggest Clic1 (zeige CLIC1 ELISA Kits) and Clic4 participate in signaling interleukin 1beta secretion and in activation of Nlrp3 (zeige NLRP3 ELISA Kits) inflammasomes; in LPS (zeige TLR4 ELISA Kits) macrophage activation, Clic1 (zeige CLIC1 ELISA Kits) and Clic4 are translocated to nucleus/cell membranes. (Clic1 (zeige CLIC1 ELISA Kits) = chloride intracellular channel 1 (zeige CLIC1 ELISA Kits); Clic4 = chloride intracellular channel 4, mitochondrial; Nlrp3 (zeige NLRP3 ELISA Kits) = NLR family pyrin domain containing 3 (zeige NLRP3 ELISA Kits))
study reports an alternately-spliced form of Smad7 (zeige SMAD7 ELISA Kits), Smad7Delta, that is induced by TGF-beta (zeige TGFB1 ELISA Kits) and CLIC4, is a dominant inhibitor of Smad7 (zeige SMAD7 ELISA Kits) and enhances TGF-beta (zeige TGFB1 ELISA Kits) signaling
The findings indicate that CLIC4/CLIC5A-mediated ERM activation is required for maintenance of the glomerular capillary architecture.
CLIC4 is not required for collaterogenesis but is essential for perinatal maturation of nascent collaterals through a mechanism that supports VEGF (zeige VEGFA ELISA Kits) signaling.
However, the absence of CLIC4 has no significant impact on the extent of functional recovery or fibrosis following acute injury.
Data suggest that compartmentalized expression of chloride intracellular channel 4 (CLIC4) in specific adult tissues and cells provides a focus to explore potential functions of this protein.
These results indicate that CLIC4 participates in skin healing and corneal wound reepithelialization through enhancement of epithelial migration by a mechanism that may involve a compromised TGF-beta (zeige TGFB1 ELISA Kits) pathway.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family\; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).
chloride intracellular channel 4 like
, chloride intracellular channel protein 4
, intracellular chloride ion channel protein p64H1
, chloride intracellular channel 4 (mitochondrial)
, mitochondrial chloride intracellular channel 4
, chloride intracellular channel 4
, Chloride intracellular channel protein 4