Chloride Channel Accessory 1 Proteine (CLCA1)

CLCA1 encodes a member of the calcium sensitive chloride conductance protein family. Zusätzlich bieten wir Ihnen Chloride Channel Accessory 1 Antikörper (59) und Chloride Channel Accessory 1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CLCA1 1179 A8K7I4
Ratte CLCA1 CLCA1 308015  
CLCA1 23844 Q9D7Z6
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$12,127.90
Details
Insektenzellen Maus rho-1D4 tag,His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$12,127.90
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$752.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag Figure. SDS-PAGE; Sample: Active recombinant CLCA1, Human. 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$1,280.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$682.25
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CLCA1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Chloride Channel Accessory 1 (CLCA1) Interaktionspartnern

Human Chloride Channel Accessory 1 (CLCA1) Interaktionspartner

  1. Increase in TMEM16A (zeige ANO1 Proteine) activity occurred within minutes of exposure to CLCA1 or after a short treatment with nocodazole, consistent with the hypothesis that CLCA1 stabilizes TMEM16A (zeige ANO1 Proteine) at the cell surface by preventing its internalization.

  2. Data show that calcium-activated chloride channel regulator 1 (CLCA1) and transmembrane protein 16A (TMEM16A (zeige ANO1 Proteine)) co-localize and physically interact and that CLCA1 increases the level of TMEM16A (zeige ANO1 Proteine) protein at the cell surface.

  3. inhibitor and siRNA transfection studies demonstrated an apparent effect of CLCA1 on ovarian cancer cell aggregation

  4. Results confirmed that the low expression of CLCA1 in CRC (zeige CALR Proteine) was associated with tumorigenesis, early metastasis, and high chromosomal instability. Low expression of CLCA1 predicts recurrence and lower survival.

  5. These findings demonstrate the ability of hCLCA1 to function as a signaling molecule and activate macrophages, central regulators of airway inflammation.

  6. CLCA1 may contribute to promoting spontaneous differentiation and reducing proliferation of Caco-2 cells.

  7. CLCA1 expression is significantly related to mucus production in the airway epithelia of smokers and COPD (zeige ARCN1 Proteine) patients, and may contribute to the development and pathogenesis of COPD (zeige ARCN1 Proteine) by inducing mucus production.

  8. These data provide both a mechanistic basis for CLCA1 self-cleavage and a novel mechanism for regulation of chloride channel activity specific to the mucosal interface.

  9. Increased expression of hCLCA1 in allergic rhinitis was correlated with the expression of MUC5AC.

  10. in cultured nasal airway cells, Th2 type cytokines increased hCLCA1 (calcium-activated chloride channel 1) expression in Cystic Fibrosis (zeige S100A8 Proteine) patients but not mucus expression

Horse (Equine) Chloride Channel Accessory 1 (CLCA1) Interaktionspartner

  1. These data implicate CLCA1 in the expression of eqMUC5AC in horses; and suggest regulation by CLCA1 and epidermal growth factor receptor (zeige EGFR Proteine) between horses with recurrent airway obstruction and those with milder degrees of inflammation.

  2. In this study, eCLCA1 protein and mRNA expression were quantified in airway goblet cells of horses with RAO (zeige AOC2 Proteine) and controls using immunohistochemistry and laser microdissection followed by RT-PCR, respectively.

Pig (Porcine) Chloride Channel Accessory 1 (CLCA1) Interaktionspartner

  1. pCLCA1 shares essential characteristics of hCLCA1, supporting the pig model as a promising tool for studying the modulating role of pCLCA1 in the complex pathology of cystic fibrosis (zeige S100A8 Proteine).

  2. pCLCA1 expression may increase the sensitivity of preexisting endogenous Cl(-) channels to Ca(2 (zeige CA2 Proteine)+) and cAMP agonists but apparently lacks inherent Cl(-) channel activity under growth conditions where endogenous channels are not expressed

Mouse (Murine) Chloride Channel Accessory 1 (CLCA1) Interaktionspartner

  1. Clca1 is not required for mucus synthesis, structure and barrier function in the murine colon.

  2. mCLCA3 appears to modulate leukocyte response via IL-17 (zeige IL17A Proteine) and murine CXCL-8 (zeige IL8 Proteine) homologs in acute Staphylococcus aureus pneumonia which is well in line with the proposed function of hCLCA1 as a signaling molecule acting on alveolar macrophages.

  3. Findings suggest that increased expression of a single-gene, mCLCA3, could simulate an asthma attack, and its mechanism may involve mCLCA3 overexpression up-regulating IL-13 (zeige IL13 Proteine) expression.

  4. PA-LPS (zeige TLR4 Proteine)-induced MUC5AC and Clca3 expression is partly through Duox1 (zeige DUOX1 Proteine)

  5. these findings argue against a role of mCLCA3 in Ca(2 (zeige CA2 Proteine) )-activated Cl(-) channel-mediated Cl(-) secretion in murine respiratory epithelia

  6. a functional link between two distinct anion currents, ClC-3 (zeige CLCN3 Proteine) and swelling-activated chloride current

  7. conclude that hCLCA1 and mCLCA3 are non-integral membrane proteins and therefore cannot be chloride channels in their own right

  8. Gob-5 expression is not essential for mucin (zeige SLC13A2 Proteine) overproduction in vitro or in murine models of allergic asthma

  9. We found that mClCA3 expression was significantly decreased in the colon and lung of the cftr (zeige CFTR Proteine)-/- mice.

  10. These observations reinforce findings that associate Gob-5 with goblet cell hyperplasia and mucus production in the allergic immune response, but also implicate Gob-5 in the regulation of tissue inflammation in the innate immune response.

Chloride Channel Accessory 1 (CLCA1) Protein Überblick

Protein Überblick

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.

Genbezeichner und Symbole assoziert mit CLCA1

  • chloride channel accessory 1 (CLCA1)
  • chloride channel accessory 1 (Clca1)
  • chloride channel accessory 1 (clca1)
  • chloride channel (clcA1)
  • chloride channel protein (clcA1)
  • AECC Protein
  • CACC Protein
  • CaCC-1 Protein
  • CACC1 Protein
  • Clca1 Protein
  • Clca2 Protein
  • Clca3 Protein
  • CLCRG1 Protein
  • fi39d11 Protein
  • gob-5 Protein
  • gob5 Protein
  • hCaCC-1 Protein
  • hCLCA1 Protein
  • wu:fi39d11 Protein

Bezeichner auf Proteinebene für CLCA1

CLCA family member 1, chloride channel regulator , calcium-activated chloride channel family member 1 , calcium-activated chloride channel protein 1 , calcium-activated chloride channel regulator 1 , calcium-dependent chloride channel-1 , chloride channel regulator 1 , chloride channel, calcium activated, family member 1 , calcium activated chloride channel 1 , calcium activated chloride channel-like protein 1 , chloride channel family member 1 , eCLCA1 , chloride channel calcium activated 3 , chloride channel accessory 1 , epithelial chloride channel protein , Clca1 protein , chloride channel , chloride channel protein , calcium-activated chloride channel regulator 1-like , calcium-activated chloride channel family member 3 , chloride channel calcium activated 2 , mCLCA3 , protein gob-5

GENE ID SPEZIES
1179 Homo sapiens
456640 Pan troglodytes
490178 Canis lupus familiaris
507643 Bos taurus
574295 Macaca mulatta
100009706 Equus caballus
308015 Rattus norvegicus
334289 Danio rerio
397284 Sus scrofa
594875 Xenopus (Silurana) tropicalis
6321729 Xanthomonas campestris pv. campestris str. B100
9398586 Leuconostoc gasicomitatum LMG 18811
100386069 Callithrix jacchus
100442837 Pongo abelii
100604179 Nomascus leucogenys
23844 Mus musculus
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