anti-Chloride Channel 2 (CLCN2) Antikörper

CLCN2 encodes a voltage-gated chloride channel. Zusätzlich bieten wir Ihnen Chloride Channel 2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CLCN2 12724 Q9R0A1
CLCN2 1181 P51788
CLCN2 29232 P35525
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Top anti-Chloride Channel 2 Antikörper auf antikoerper-online.de

Showing 10 out of 69 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Human Kaninchen Unkonjugiert EIA, WB CLCN2 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35µg/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow). CLCN2 Antibody (N-term) western blot analysis in mouse Neuro-2a cell line lysates (35µg/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
Details
Human Ziege Unkonjugiert IHC, IHC (p) Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-CLCN2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Maus Unkonjugiert RNAi, ELISA, WB CLCN2 monoclonal antibody (M01), clone 3E1 Western Blot analysis of CLCN2 expression in Hela S3 NE . Western blot analysis of CLCN2 over-expressed 293 cell line, cotransfected with CLCN2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with CLCN2 monoclonal antibody (M01), clone 3E1. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$364.00
Details
Fledermaus Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$610.50
Details
Human Kaninchen Unkonjugiert WB CLCN2 Antibody (N-term)  western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow). CLCN2 Antibody (N-term)  western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the CLCN2 antibody detected the CLCN2 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of CLCN2 using K562 whole cell lysates 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Rind (Kuh) Ziege Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 4 bis 8 Tage
$462.00
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: CLCN2 Antibody [NBP1-52032] - Analysis of CLCN2 in HeLa lysate (35ug protein in RIPA buffer) using this antibody at 0.3 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$488.73
Details
Human Ziege Unkonjugiert IHC (p) Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$495.00
Details

Am meisten referenzierte anti-Chloride Channel 2 Antikörper

  1. Human Polyclonal CLCN2 Primary Antibody für ELISA, WB - ABIN4299049 : Cornejo, Niemeyer, Zúñiga, Yusef, Sepúlveda, Cid: Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. in Journal of cellular physiology 2009 (PubMed)

  2. Human Monoclonal CLCN2 Primary Antibody für RNAi, ELISA - ABIN560397 : Alessi, Andjelkovic, Caudwell, Cron, Morrice, Cohen, Hemmings: Mechanism of activation of protein kinase B by insulin and IGF-1. in The EMBO journal 1997 (PubMed)
    Show all 4 Pubmed References

Weitere Antikörper gegen Chloride Channel 2 Interaktionspartner

Zebrafish Chloride Channel 2 (CLCN2) Interaktionspartner

  1. Identification and characterization of the zebrafish ClC-2a/b/c chloride channel orthologs.

Mouse (Murine) Chloride Channel 2 (CLCN2) Interaktionspartner

  1. High fat diet -treated mice lacking ClC-2 showed inhibited hepatic lipid accumulation via regulating lipid metabolism through decreasing sterol regulatory element binding protein (SREBP)-1c expression and its downstream targeting enzymes such as fatty acid synthase (FAS), HMG-CoA reductase (HMGCR) and acetyl-Coenzyme A carboxylase (ACCalpha).

  2. Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase, reduced tubulovesicles and reduced stimulated acid secretion.

  3. Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule GlialCAM and chloride channel ClC-2, and for changing ClC-2 currents.

  4. Loss of ClC-2 is associated with increased development of DSS-induced colitis.

  5. fast gate protonation was V(m) and Cl(-) independent and the equilibrium constant for closed-open transition of unprotonated channels was facilitated by elevated [Cl(-)](i) in a V(m)-dependent manner

  6. The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1), K(2P) channels (TREK-1 and TWIK-1) and Cl- channels (ClC2).

  7. ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.

  8. permeant Cl(-) ions contribute to V(m)-dependent gating of the broadly distributed ClC-2 Cl() channel.

  9. GABAA receptor-mediated synaptic inputs from basket cells were modulated by ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

  10. ClC-2 reduces barrier function in normal mucosa. Ultrastructural morphology of tight junctions and myosin light chain kinase appear to be important to the function of ClC-2 in normal mucosa.

  11. these findings raise the possibility that ClC-2 expression plays a subtle neuroprotective role in the aging hippocampus

  12. Heterozygous nmf240 mice present with a reduced electroretinography light peak component suggests that CLCN2 is necessary for the generation of this response component.

  13. we suggest a dual role for ClC-2 in neurons, providing an additional efflux pathway for chloride and constituting a substantial part of the background conductance, which regulates excitability.

  14. ClC-2 is unlikely to be a candidate rescue channel in cystic fibrosis

  15. activation of host ClC-2 channels participates in the altered permeability of Plasmodium-infected erythrocytes but is not required for intraerythrocytic parasite survival

  16. This study concluded that Clcn2is the inward-rectifying chloride channel in duct cells, but its expression is not apparently required for the ion reabsorption or the barrier function of salivary ductal epithelium.

  17. These data demonstrate a pivotal role of ClC-2 in recovery of the intestinal epithelium barrier by anchoring assembly of tight junctions following ischemic injury.

Pig (Porcine) Chloride Channel 2 (CLCN2) Interaktionspartner

  1. ClC-2-mediated intestinal Cl - secretion restores transepithelial resistance in ischemia-injured intestine.

Human Chloride Channel 2 (CLCN2) Interaktionspartner

  1. A role of anion channels in glomerulosa membrane potential determination, aldosterone production and hypertension. The mutations are the cause of a substantial fraction of early-onset primary aldosteronism.

  2. CLCN2 mutations cause primary aldosteronism, this highlight the importance of chloride in aldosterone biosynthesis and CLCN2 as the foremost chloride conductor of resting glomerulosa cells.

  3. The inhibitory effects of ClC-2 knockout on HBVSMC proliferation and motility were associated with inactivation of the Wnt/beta-catenin signaling pathway, as evidenced by inhibition of beta-catenin phosphorylation and nuclear translocation, and decrease of GSK-3beta phosphorylation and survivin and cyclin D1 expression.

  4. Leukoencephalopathy-causing CLCN2 mutations impair chloride channel gating and trafficking.

  5. ClC-2 mRNA level was significantly increased in patients with non-alcoholic steatohepatitis, which positively correlated with the plasma levels of alanine transaminase (ALT), aspartate transaminase (AST) and insulin.

  6. The findings show that RGET691 of human ClC-2 (possible binding site) plays an important functional role in fatty acid activation of human ClC-2.

  7. Hyperpolarization activates CLC-2 mainly by driving intracellular anions into the channel pores.

  8. The extracellular domain of GlialCAM is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2.

  9. both ubiquitous (AP-1A) and epithelium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 are capable of carrying out basolateral sorting of ClC-2.

  10. SPAK and OSR1 are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2

  11. Correlation between CLC-2 gene expression and the cytoskeleton in human trabecular meshwork cells.

  12. Our observations substantiate the concept that ClC-2 is involved in brain ion and water homoeostasis

  13. JAK2 down-regulates ClC-2 activity and thus counteracts Cl(-) exit, an effect which may impact on cell volume regulation

  14. This study demonistrated that the first auxiliary subunit of ClC-2 and suggests that ClC-2 may play a role in the pathology of MLC disease.

  15. ClC-2 plays an important role in the modulation of tight junctions by influencing caveolar trafficking of tight junction protein occludin.

  16. Sequence analysis of CLCN2 at genomic DNA and cDNA levels in 18 megalencephalic leukoencephalopathy MLC1 mutations revealed some nucleotide changes, but they were predicted to be nonpathogenic.

  17. found significant expression of ClC-2 at the apex of ciliated cells in both rat and human airways

  18. a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex.

  19. ClC-2 and ClC-3 channels are specifically upregulated in glioma membranes and endow glioma cells with an enhanced ability to transport Chloride

  20. activation of hClC-2 is differentially regulated by PKA at two sites

Chloride Channel 2 (CLCN2) Antigen-Profil

Protein Überblick

This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit CLCN2

  • chloride voltage-gated channel 2 (CLCN2) Antikörper
  • chloride channel, voltage-sensitive 2a (clcn2a) Antikörper
  • chloride channel protein 2 (EHI_142170) Antikörper
  • chloride channel protein 2 (EHI_186860) Antikörper
  • chloride channel, voltage-sensitive 2 (Clcn2) Antikörper
  • chloride voltage-gated channel 2 (Clcn2) Antikörper
  • AL118368 Antikörper
  • CIC-2 Antikörper
  • clC-2 Antikörper
  • Clc2 Antikörper
  • CLCN2 Antikörper
  • ECA2 Antikörper
  • ECA3 Antikörper
  • EGI3 Antikörper
  • EGI11 Antikörper
  • EGMA Antikörper
  • EJM6 Antikörper
  • EJM8 Antikörper
  • LOC100150892 Antikörper
  • nmf240 Antikörper

Bezeichner auf Proteinebene für CLCN2

chloride channel 2 , novel protein similar to vertebrate chloride channel 2 (CLCN2) , chloride channel protein 2 , PKA-activated chloride channel ClC-2G , clC-2

GENE ID SPEZIES
704709 Macaca mulatta
100125625 Ovis aries
100150892 Danio rerio
3405494 Entamoeba histolytica HM-1:IMSS
3410767 Entamoeba histolytica HM-1:IMSS
12724 Mus musculus
505569 Bos taurus
100135500 Cavia porcellus
397147 Sus scrofa
1181 Homo sapiens
29232 Rattus norvegicus
488106 Canis lupus familiaris
100009530 Oryctolagus cuniculus
425295 Gallus gallus
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