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Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine.
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The soluble antigen from A. cantonensis could promote the Chil3 expression in macrophage and microglial cell lines induced by interleukin-13 (zeige IL13 Antikörper).
A significant increase of CHI3L3 mRNA expression was observed in the spinal cord of experimental autoimmune encephalitis mice compared to controls during the inflammatory phase.
neutrophil-derived Ym1 protein uptake distinguishes wound macrophages in the absence of interleukin-4 (zeige IL4 Antikörper) signaling in murine wound healing
These results indicate that catalytically inactive BRP (zeige GDF5 Antikörper)-39 and Ym1 are constitutive genes in normal mouse lung.
These data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1.
These results showed that Ym1 was most highly expressed in the brains and cerebrospinal fluid of the Angiostrongylus cantonensis infected mice along with the process of inflammation.
findings implicate heparanase (zeige HPSE Antikörper) in normal processing of heparan sulfate in macrophages, and indicate that heparanase (zeige HPSE Antikörper) regulates intracellular Ym1 accumulation and crystal formation in airways.
TH2 cytokines and allergic challenge induce expression in macrophages by a STAT6 (zeige STAT6 Antikörper)-dependent mechanism
data show ECF-L is a previously unknown factor that is a potent mediator of osteoclast formation, which acts at the later stages of osteoclast formation and enhances the effects of RANKL (zeige TNFSF11 Antikörper)
crystal structure of Ym1 at 1.31 A resolution
Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger. Binds chitin and heparin. Has no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy.
chitinase-3-like protein 3
, eosinophil chemotactic cytokine
, eosinophil chemotactic factor-L
, secreted protein Ym1