anti-Chitinase 3-Like 3 (CHI3L3) Antikörper

Mouse (Murine) Chitinase 3-Like 3 (CHI3L3) Interaktionspartner

1. The soluble antigen from A. cantonensis could promote the Chil3 expression in macrophage and microglial cell lines induced by interleukin-13.

2. A significant increase of CHI3L3 mRNA expression was observed in the spinal cord of experimental autoimmune encephalitis mice compared to controls during the inflammatory phase.

3. neutrophil-derived Ym1 protein uptake distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing

4. These results indicate that catalytically inactive BRP-39 and Ym1 are constitutive genes in normal mouse lung.

5. These data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1.

6. These results showed that Ym1 was most highly expressed in the brains and cerebrospinal fluid of the Angiostrongylus cantonensis infected mice along with the process of inflammation.

7. findings implicate heparanase in normal processing of heparan sulfate in macrophages, and indicate that heparanase regulates intracellular Ym1 accumulation and crystal formation in airways.

8. was shown to be a neutrophil granule protein and to have weak beta-N-acetylglucosaminidase activity, indicating that it might contribute to the digestion of glycosaminoglycans.

9. TH2 cytokines and allergic challenge induce expression in macrophages by a STAT6-dependent mechanism

10. data show ECF-L is a previously unknown factor that is a potent mediator of osteoclast formation, which acts at the later stages of osteoclast formation and enhances the effects of RANKL

11. crystal structure of Ym1 at 1.31 A resolution

12. Constitutively expressed in bone marrow cells and gradually decreased in the presence of IL-3.

13. These results indicate that ECF-L may play a critical role in allergic inflammation and bronchial asthma.

14. Results suggest that modulation of Ym1 production by dendritic cells identifies a previously undescribed mechanism of Th2 polarization by statin.

15. Quantitative RT-PCR demonstrated a 976-fold increase of Chi3l4 mRNA expression and a 24-fold increase of Chi3l3 mRNA expression in the skin of cpdm/cpdm mice.

16. ECF-L enhances RANKL and 1,25-(OH)2D3-induced OCL formation by increasing adhesive interactions between OCL precursors through increased expression of ICAM-1 and LFA-1.

17. Bronchoalveolar lavage fluid protein Ym1 is cleaved by matrix metalloproteinases 2 and 9 and is essential for regulating inflammatory pathways in experimental asthma.

18. Glucocorticoid receptor-null lungs included Chi3l3 (11-fold, P < 0.05), a macrophage inflammatory response gene and Ela1 (9.4-fold, P < 0.05), an extracellular matrix remodeling enzyme.

19. Production of Ym1/2 in response to interleukin-13 promotes T helper type (Th)2 cell cytokine production and allergic airway inflammation by inhibiting the production of 12(S)-hydroxyeicosatetraenoic acid (HETE) by 12/15(S)-lipoxygenase (LOX).

20. Crystalline macrophage pneumonia is due to overexpression of ym1 (now chi3I3) in lung macrophages which causes illness and death in mice.