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Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers.
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Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression.
FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes.
chronic Cby1 knockdown in colon cancer cells may counteract tumor progression by promoting the mesenchymal-to-epithelial transition process.
Cby's C-terminal domain alone binds to TC-1 with significantly greater affinity compared to full-length Cby, implying that target binding of the coiled-coil domain is affected by the flanking disordered regions.
CBY1 downregulation in CML (zeige BCR ELISA Kits) comes from reduced protein stability when bound to 14-3-3sigma adapter protein (zeige TOLLIP ELISA Kits). Dissociation raises CBY1 protein levels by enhancing its stability. The ubiquitin proteasome system reduces 14-3-3sigma-bound CBY1 stability by SUMOylation.
Results show the hypermethylation of CBY1 and BCL2 (zeige BCL2 ELISA Kits)-like11 promoters proceeding from DNMT1 (zeige DNMT1 ELISA Kits) is a crucial component of their reduced expression, but it is not directly involved in chronic myeloid leukemia (zeige BCL11A ELISA Kits) resistance to imatinib.
Study showed that expression of Cby protein was strongly downregulated in laryngeal squamous cell carcinoma (LSCC) tumor tissues in comparison to normal laryngeal mucosa samples.
the impact of BCR (zeige BCR ELISA Kits)-ABL1 (zeige ABL1 ELISA Kits) on Chibby1, a beta catenin (zeige CTNNB1 ELISA Kits) antagonist involved in cell differentiation and transformation
Stable expression of CBY1 drives beta catenin (zeige CTNNB1 ELISA Kits) cytoplasmatic translocation and impairs beta catenin (zeige CTNNB1 ELISA Kits) signaling in BCR-ABL (zeige ABL1 ELISA Kits) + cells.
Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population.
C-terminal polycystin-2 (zeige PKD2 ELISA Kits) influences the interaction with PIGEA14
Cby1 is required for efficient recruitment of Ahi1 (zeige AHI1 ELISA Kits), providing a possible molecular mechanism for the ciliogenesis defect in Cby1(-/-) cells.
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.
chibby homolog 1
, leucine-rich protein
, ARPP-binding protein
, PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
, PKD2 interactor, golgi and endoplasmic reticulum associated 1
, coiled-coil protein PIGEA-14
, cytosolic leucine-rich protein
, polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein, 14 kDa
, protein chibby homolog 1