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CCBP2 encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors.
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Human Monoclonal CCBP2 Primary Antibody für CyTOF, FACS - ABIN4899116
Martinez de la Torre, Buracchi, Borroni, Dupor, Bonecchi, Nebuloni, Pasqualini, Doni, Lauri, Agostinis, Bulla, Cook, Haribabu, Meroni, Rukavina, Vago, Tedesco, Vecchi, Lira, Locati, Mantovani: Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. in Proceedings of the National Academy of Sciences of the United States of America 2007
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Human Polyclonal CCBP2 Primary Antibody für IHC (p), ELISA - ABIN4369828
Soler, Humphreys, Spinola, Campbell: CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. in Blood 2003
Show all 3 Pubmed References
Data show the structural motifs in the atypical chemokine receptor 2 (ACKR2) are responsible for ligand binding, and suggest ACKR2-derived N-terminal peptides as being of potential therapeutic significance.
engagement of the ACR (zeige ACR Antikörper) D6 by its ligands activates a beta (zeige SUCLA2 Antikörper)-arrestin1 (zeige ARRB1 Antikörper)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein (zeige KPTN Antikörper) cofilin (zeige CFL1 Antikörper) through the Rac1-PAK1 (zeige PAK1 Antikörper)-LIMK1 (zeige LIMK1 Antikörper) cascade.
co-expression of DARC (zeige DARC Antikörper), D6, and CCX-CKR (zeige CCRL1 Antikörper) significantly associated with higher survival in gastric cancer
CCL2 binding to primary adult human astrocytes is CCR2-independent and is likely to be mediated via the D6 decoy.
D6 is expressed in AMs (zeige MAT1A Antikörper) from patients with COPD (zeige ARCN1 Antikörper), and its expression correlates with the degree of functional impairment and markers of immune activation.
Chemokine (zeige CCL1 Antikörper) decoy receptor D6 limits CC-chemokine (zeige CCL1 Antikörper)-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction.
DARC (zeige DARC Antikörper) and D6, the most studied members of this group of molecules, are reviewed.
CCR10 (zeige CCR10 Antikörper) is unlikely to be necessary for cutaneous homing of TH cells in the models studied here. CCR10 (zeige CCR10 Antikörper) may instead play a role in the movement of specialized "effector" cutaneous TH cells to and/or within epidermal microenvironments.
CCR10 (zeige CCR10 Antikörper) and its mucosal epithelial ligand CCL28 (zeige ENC1 Antikörper) have roles in the migration of circulating IgA (zeige IgA Antikörper) plasmablasts
ACKR2 (Ccbp2) is a key regulator of myeloid differentiation and function and its targeting unleashes the anti-metastatic activity of neutrophils.
study found that the inflammatory chemokine (zeige CCL1 Antikörper) CCL5 (zeige CCL5 Antikörper) is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 (zeige CCL5 Antikörper) exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN (zeige TBCE Antikörper)-expressed D6.
Further examination revealed that proximity of pro-lymphangiogenic macrophages to developing lymphatic vessel surfaces is increased in ACKR2-deficient mice and reduced in CCR2-deficient mice.
some cells, including plasmacytoid dendritic cells, can express both CCR2 (zeige CCR2 Antikörper) and ACKR2; that Ly6C(high) monocytes have particularly strong CCL2 (zeige CCL2 Antikörper)-scavenging potential in vitro and in vivo; and that CCR2 (zeige CCR2 Antikörper) is a much more effective CCL2 (zeige CCL2 Antikörper) scavenger than ACKR2.
control of CCR2 ligands by D6 regulates the traffic of Ly6C(high) monocytes and controls their immunosuppressive potential.
D6, by suppressing inflammatory chemokine (zeige CCL1 Antikörper) binding to lymphatic surfaces, and thereby preventing inflammatory leukocyte adherence, is a regulator of lymphatic function and a contributor to the integration of innate and adaptive immune responses.
identify novel D6(active) B1-cell subsets, including those we term B1d, which lack CD5 (zeige CD5 Antikörper) and CD11b (zeige ITGAM Antikörper) but exhibit typical B1-cell properties, including spontaneous ex vivo production of IgM (zeige CD40LG Antikörper), IL-10 (zeige IL10 Antikörper), and anti-phosphorylcholine antibody
the chemokine (zeige CCL1 Antikörper) scavenger receptor D6 has a non-redundant role in acute toxic liver injury in vivo; results support the importance of post-translational chemokine (zeige CCL1 Antikörper) regulation and describe a new mechanism of immune modulation within the liver
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members\; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
C-C chemokine receptor D6
, CC-chemokine-binding receptor JAB61
, chemokine (C-C motif) receptor 9
, chemokine (C-C) receptor 9
, chemokine binding protein 2
, chemokine receptor CCR-10
, chemokine receptor CCR-9
, chemokine receptor D6
, chemokine-binding protein 2
, chemokine-binding protein D6
, CCR10-related receptor
, D6 beta-chemokine receptor