anti-Chemokine Binding Protein 2 (CCBP2) Antikörper

CCBP2 encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Zusätzlich bieten wir Ihnen CCBP2 Proteine (6) und CCBP2 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CCBP2 1238 O00590
CCBP2 140473  
CCBP2 59289 O08707
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Top anti-CCBP2 Antikörper auf antikoerper-online.de

Showing 10 out of 98 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, WB Human Muscle WB Suggested Anti-CCBP2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IF, ELISA Immunofluorescence analysis of A549 cells, using CCBP2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IF, ELISA, WB Western blot analysis of extracts from HepG2 cells, using CCBP2 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of COS7 cells, using CCBP2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB The anti-CCBP2 N-term Pab (ABIN388745) is used in Western blot to detect CCBP2 in mouse liver tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-CCBP2 Pab (ABIN388746) in mouse small intestine tissue lysate. CCBP2 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Ratte Unkonjugiert CyTOF, FACS Detection of CC Chemokine Receptor D6 in NS0 Mouse Cell Line Transfected with Human CC Chemokine Receptor D6 by Flow Cytometry. NS0 mouse myeloma cell line transfected with human CC Chemokine Receptor D6 was stained with Rat Anti-Human CC Chemokine Receptor D6 Monoclonal Antibody. 500 μg Anmelden zum Anzeigen 8 bis 9 Tage
$397.76
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Anmelden zum Anzeigen Verfügbar
$363.46
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, IHC (p), WB Human Lung, Respiratory Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details

Am meisten referenzierte anti-CCBP2 Antikörper

  1. Human Monoclonal CCBP2 Primary Antibody für CyTOF, FACS - ABIN4899116 : Martinez de la Torre, Buracchi, Borroni, Dupor, Bonecchi, Nebuloni, Pasqualini, Doni, Lauri, Agostinis, Bulla, Cook, Haribabu, Meroni, Rukavina, Vago, Tedesco, Vecchi, Lira, Locati, Mantovani: Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal CCBP2 Primary Antibody für IHC (p), ELISA - ABIN4369828 : Soler, Humphreys, Spinola, Campbell: CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. in Blood 2003 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal CCBP2 Primary Antibody für IHC (p), ELISA - ABIN544799 : Fra, Locati, Otero, Sironi, Signorelli, Massardi, Gobbi, Vecchi, Sozzani, Mantovani: Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. in Journal of immunology (Baltimore, Md. : 1950) 2003 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen CCBP2 Interaktionspartner

Human Chemokine Binding Protein 2 (CCBP2) Interaktionspartner

  1. Data suggest that MIRN146b and MIR10b directly bind 3'-untranslated region of ACKR2 and down-regulate expression of ACKR2 in keratinocytes and in lymphatic endothelial cells, respectively. (ACKR2 = atypical chemokine receptor 2)

  2. ACKR2 is induced after traumatic brain injuries and has a significant impact on mortality and lesion development acutely following closed head injury.

  3. ACKR2 is a molecular regulator play a role in inflammatory changes in patients with psoriasis.

  4. Data indicates that D6 is concentrated on trophoblast cell membranes in pre-eclampsia, in line with higher circulating levels of D6-ligand chemokines, but its scavenging activity is affected by trophoblast cytoskeleton disarrangement.

  5. ACKR2 mediates chemokine scavenging by primary human trophoblasts.

  6. Data show the structural motifs in the atypical chemokine receptor 2 (ACKR2) are responsible for ligand binding, and suggest ACKR2-derived N-terminal peptides as being of potential therapeutic significance.

  7. Data show that low decoy receptor D6 expression correlated to more invasive tumors and that tumor location influences D6 expression, which is lower in the more distal parts of the colon.

  8. engagement of the ACR D6 by its ligands activates a beta-arrestin1-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin through the Rac1-PAK1-LIMK1 cascade.

  9. co-expression of DARC, D6, and CCX-CKR significantly associated with higher survival in gastric cancer

  10. D6, which is upregulated in both inflammatory and tumor contexts, is an essential regulator of inflammatory leukocyte interactions with lymphatic endothelial cells(LECs) and is required for immature/mature DC discrimination by LECs.

  11. We here summarize the knowledge available today on D6 structural and signaling properties and its essential role for the control of inflammatory cells traffic and proper development of the adaptive immune response.

  12. CCL2 binding to primary adult human astrocytes is CCR2-independent and is likely to be mediated via the D6 decoy.

  13. D6 is expressed in AMs from patients with COPD, and its expression correlates with the degree of functional impairment and markers of immune activation.

  14. These data demonstrate a novel role for D6 as a regulator of the transition from uninvolved to lesional skin in psoriasis.

  15. Chemokine decoy receptor D6 limits CC-chemokine-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction.

  16. DARC and D6, the most studied members of this group of molecules, are reviewed.

  17. Chemokne D6 expression is higher in biopsies taken from more severe cardiac allograft rejection.

  18. D6 protein is found predominantly inside human choriocarcinoma-derived cells with only a small fraction available on the cell surface at any one time, yet it can progressively remove extracellular chemokines, without apparent desensitization.

  19. CCR10 is unlikely to be necessary for cutaneous homing of TH cells in the models studied here. CCR10 may instead play a role in the movement of specialized "effector" cutaneous TH cells to and/or within epidermal microenvironments.

  20. In lymphatic vessels D6 acts as a nonsignaling decoy receptor and scavenger for inflammatory CC chemokines, by clearing them and preventing excessive diffusion via afferent lymphatics to lymph nodes.

Mouse (Murine) Chemokine Binding Protein 2 (CCBP2) Interaktionspartner

  1. ACKR2 controls the CC chemokine expression that drives the influx of CCR2(+) and CCR5(+) IFNgamma-producing gammadeltaT cells, tuning the Th17 response that mediated pulmonary fibrosis triggered by bleomycin instillation.

  2. ACKR2 is important in limiting renal inflammation and fibrotic remodeling in progressive nephrotoxic glomerulonephritis.

  3. ACKR2 (Ccbp2) is a key regulator of myeloid differentiation and function and its targeting unleashes the anti-metastatic activity of neutrophils.

  4. ACKR2 is induced after traumatic brain injuries and has a significant impact on mortality and lesion development acutely following closed head injury.

  5. study found that the inflammatory chemokine CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN-expressed D6.

  6. ACKR2 is an important regulator of branching morphogenesis in diverse biological context; this provide the first evidence of a role for chemokines and their receptors in postnatal development processes.

  7. Ackr2 expression levels limits development of cutaneous inflammatory responses in psoriasis.

  8. ACKR2 deletion reduced renal inflammation in diabetes and the ultimate response was a high degree of protection from diabetic nephropathy.

  9. Ackr2 deficiency does not suppress autoreactive T-cell priming and autoimmune pathology, but can enhance T-cell polarization toward Th17 cells.

  10. ACKR2 can regulate fetal growth, placental structure, and neonatal mortality in mice.

  11. Further examination revealed that proximity of pro-lymphangiogenic macrophages to developing lymphatic vessel surfaces is increased in ACKR2-deficient mice and reduced in CCR2-deficient mice.

  12. some cells, including plasmacytoid dendritic cells, can express both CCR2 and ACKR2; that Ly6C(high) monocytes have particularly strong CCL2-scavenging potential in vitro and in vivo; and that CCR2 is a much more effective CCL2 scavenger than ACKR2.

  13. Expression of the D6 receptor mediates dendritic cell function and promotes corneal allograft rejection.

  14. Our data therefore indicate that D6 is able to play a cell-autonomous role as a migratory rheostat restricting migration of D6-expressing cells such as neutrophils

  15. These data demonstrate a novel role for D6 as a regulator of the transition from uninvolved to lesional skin in psoriasis.

  16. results indicate a novel mode of action for D6 during the resolution of inflammation that is instrumental to the shaping of resolving macrophage phenotypes and the completion of resolution

  17. Chemokine decoy receptor D6 limits CC-chemokine-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction.

  18. control of CCR2 ligands by D6 regulates the traffic of Ly6C(high) monocytes and controls their immunosuppressive potential.

  19. D6, by suppressing inflammatory chemokine binding to lymphatic surfaces, and thereby preventing inflammatory leukocyte adherence, is a regulator of lymphatic function and a contributor to the integration of innate and adaptive immune responses.

  20. identify novel D6(active) B1-cell subsets, including those we term B1d, which lack CD5 and CD11b but exhibit typical B1-cell properties, including spontaneous ex vivo production of IgM, IL-10, and anti-phosphorylcholine antibody

CCBP2 Antigen-Profil

Protein Überblick

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members\; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.

Genbezeichner und Symbole assoziert mit CCBP2

  • atypical chemokine receptor 2 (ACKR2) Antikörper
  • atypical chemokine receptor 2 (Ackr2) Antikörper
  • atypical chemokine receptor 2-like (LOC100219492) Antikörper
  • chemokine receptor D6 (LOC733624) Antikörper
  • C-C motif chemokine receptor 9 (CCR9) Antikörper
  • AI464239 Antikörper
  • Ccbp2 Antikörper
  • CCR9 Antikörper
  • CCR10 Antikörper
  • Cmkbr9 Antikörper
  • D6 Antikörper
  • hD6 Antikörper
  • LOC733624 Antikörper

Bezeichner auf Proteinebene für CCBP2

C-C chemokine receptor D6 , CC-chemokine-binding receptor JAB61 , chemokine (C-C motif) receptor 9 , chemokine (C-C) receptor 9 , chemokine binding protein 2 , chemokine receptor CCR-10 , chemokine receptor CCR-9 , chemokine receptor D6 , chemokine-binding protein 2 , chemokine-binding protein D6 , CCR10-related receptor , D6 beta-chemokine receptor , C-C chemokine receptor type 9

GENE ID SPEZIES
1238 Homo sapiens
140473 Rattus norvegicus
420393 Gallus gallus
460298 Pan troglodytes
485618 Canis lupus familiaris
512583 Bos taurus
100219492 Taeniopygia guttata
100345678 Oryctolagus cuniculus
733624 Sus scrofa
100589553 Nomascus leucogenys
59289 Mus musculus
530951 Bos taurus
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