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Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Zusätzlich bieten wir Ihnen CXCL16 Antikörper (198) und CXCL16 Kits (85) und viele weitere Produktgruppen zu diesem Protein an.
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Women with gestational diabetes mellitus and preeclampsia had a dysregulated CXC chemokine ligand 16 during pregnancy, and in gestational diabetes mellitus, the increase in CXC chemokine ligand 16 early in pregnancy and after 5 years was strongly associated with their lipid profile.
Data suggest that primary cells from papillary renal cell carcinoma (zeige MOK Proteine) secrete the chemokines IL8 (zeige IL8 Proteine), CXCL16, and chemerin (zeige RARRES2 Proteine); these chemokines attract primary human monocytes and induce shift/transdifferentiation in monocytes toward M2 macrophage/foam cell phenotype. (IL8 (zeige IL8 Proteine) = interleukin-8 (zeige IL8 Proteine); CXCL16 = C-X-C motif chemokine (zeige CCL1 Proteine) ligand 16)
Our study demonstrated that CXCL16-CXCR6 (zeige CXCR6 Proteine) mediates CD8 (zeige CD8A Proteine)(+) T-cell skin trafficking under oxidative stress in patients with vitiligo (zeige MITF Proteine), and CXCL16 expression in human keratinocytes induced by ROS (zeige ROS1 Proteine) is, at least in part, caused by unfolded protein response activation
eGFR (zeige EGFR Proteine) and serum albumin (zeige ALB Proteine) had an independent and significant negative correlation with plasma CXCL16 in diabetic kidney disease.
The expression of CXCL16 and and its receptor, CXCR6 (zeige CXCR6 Proteine), their immunolocalization in disc tissue and their presence following exposure of cultured human annulus fibrosus cells to proinflammatory cytokines are reported.
Inflammation contributed to foam cell formation in the radial arteries of ESRD patients via activation of the CXCL16/CXCR6 (zeige CXCR6 Proteine) pathway, which may be regulated by P2X7R (zeige P2RX7 Proteine).
CXCL16 single nucleotide polymorphisms significantly impacted myocardial infarction risk in a Chinese Han population.
Transmembrane-CXCL16 specifically acts as a receptor for soluble-CXCL16 in human meningioma cells.
Higher levels CXCL16 may be a biomarker for predicting stroke incidence and might contribute to plaque destabilization.
CXCL16 is released into the circulation as a result of cardiac surgery and that high post-operative CXCL16 levels are associated with an increased severity of post-operative organ dysfunctions.
CXCL16 plays a crucial role in the pathogenesis of cisplatin-induced acute kidney injury through regulation of apoptosis and inflammation.
These findings suggest that the CXCL16 gene product promotes inflammatory factors and cell infiltration factors, and inhibits the expression of antioxidant factors to accelerate the development of DN, and CXCL16 deficiency attenuates DN may be involved in the AKT (zeige AKT1 Proteine) signaling pathway.
Results indicate that CXCL16 plays a pivotal role in the pathogenesis of renal artery stenosis-induced renal injury and fibrosis through regulation of bone marrow-derived fibroblast accumulation and macrophage and T-cell infiltration.
Simvastatin exerts a protective effect on renal function and structure in mice with ADR (zeige SARS Proteine) nephropathy which related to the decreasing expression of CXCL16 in glomerular podocytes followed by the decreasing endocytosis of ox-LDL in podocytes and inhibition of NF-kappaB (zeige NFKB1 Proteine) pathway activation.
These results indicate that MEK (zeige MDK Proteine) inhibitor diminishes Nasopharyngeal carcinoma cell proliferation and NPC (zeige NPC1 Proteine)-induced osteoclastogenesis via modulating CCL2 (zeige CCL2 Proteine) and CXCL16 expressions.
Serum CXCL16 is increased in severe pancreatitis with infected pancreatic necrosis and identifies patients who benefit from surgical necrosectomy
injured hepatocytes up-regulated CXCL16 expression, indicating that scavenging functions of CXCL16 might be additionally involved in the pathogenesis of NAFLD.
role of IFN-gamma (zeige IFNG Proteine), CXCL16, and ADAM10 (zeige ADAM10 Proteine) in oxLDL-induced lipid accumulation in glomerular podocytes
CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-alpha (zeige TNF Proteine)-induced apoptosis by tumor-associated macrophages.
Loss of sst2 (zeige SSTR2 Proteine) from pancreatic tissues activates PI3K signaling via AKT (zeige AKT1 Proteine), leading to activation of NF-kappaB (zeige NFKB1 Proteine), amplification of oncogenic KRAS signaling, increased expression of CXCL16, and pancreatic tumor formation.
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
chemokine (C-X-C motif) ligand 16
, small inducible cytokine B14
, C-X-C motif chemokine 16
, CXC chemokine ligand 16
, scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
, small-inducible cytokine B16
, transmembrane chemokine CXCL16
, Cxc chemokine ligand 16
, zinc finger, MYND-type containing 15
, Transmembrane chemokine CXCL16