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CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors.
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Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery.
Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine (zeige CCL1 ELISA Kits) and Small Molecule Binding.
High CCR8 expression is associated with high recurrence in kidney cancer.
findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease
Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin.
CCL1 (zeige CCL1 ELISA Kits)-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis.
Identification of human CCR8 as a CCL18 (zeige CCL18 ELISA Kits) receptor.
CCR8(+) myeloid cell subset is expanded in patients with cancer.
Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes.
C-terminal clipping of chemokine CCL1 (zeige CCL1 ELISA Kits)/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity
CCR8 negatively regulates migration of cutaneous dendritic cells from the skin to the draining lymph nodes in contact hypersensitivity by keeping these cells in the skin.
Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages.
A sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c (zeige ITGAX ELISA Kits)(+) Aantigen presenting cells.
Expression of CCR-8 in microglia was upregulated in the presence of CCL-1 (zeige CCL1 ELISA Kits).
Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice.
a key regulator of Th2 cell skin recruitment during IL-5 (zeige IL5 ELISA Kits)-mediated allergic inflammation
mediates increased responsiveness of murine eosinophils to TCA-3 (zeige CCL1 ELISA Kits)
Data from three different models plus an in vivo blocking study clearly show that the Th2 cell-mediated pathological response to ovalbumin (zeige OVA ELISA Kits)-induced allergic airway inflammation is not critically CCR8-dependent.
sulfation at specific positions of the N-terminal domain of mouse CCR8 is critical for its biological activity, whereas glycosylation has a minor influence
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.
C-C chemokine receptor type 8
, CC chemokine receptor 8
, CC chemokine receptor CHEMR1
, CC-chemokine receptor chemr1
, chemokine (C-C) receptor 8
, chemokine (C-C) receptor-like 2
, chemokine receptor-like 1
, C-C motif chemokine receptor 8