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Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors.
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CCR10 may be a key regulator in breast cancer cell invasion and migration
CCR10/CCL27 (zeige CCL27 ELISA Kits) crosstalk mediated drug resistance, contributing to failure of proteasome-inhibitors in multiple myeloma.
CCL27 (zeige CCL27 ELISA Kits) drives baseline recruitment of Herpes simplex virus-specific CD8 (zeige CD8A ELISA Kits) T cells expressing CCR10, while interferon (zeige IFNA ELISA Kits)-responsive CXCR3 (zeige CXCR3 ELISA Kits) ligands recruit additional cells in response to virus-driven inflammation.
Findings support the notion that CCR10 and its ligand CCL27 (zeige CCL27 ELISA Kits) may contribute to the skin infiltration of malignant T-cells in mycosis fungoides and adult T-cell leukemia/lymphoma.
low CCL27 (zeige CCL27 ELISA Kits)/CCR10 and CXCL12 (zeige CXCL12 ELISA Kits)/CXCR4 (zeige CXCR4 ELISA Kits) intratumoral mRNA ratios are associated with melanoma progression
CCR7 (zeige CCR7 ELISA Kits) overexpression correlated with expression of metallothionein (zeige MT ELISA Kits), while CCR10 was associated with cerebral metastases. CCR7 (zeige CCR7 ELISA Kits) and CCR10 overexpressions were associated with a worse outcome independent of Breslow's tumor thickness and Clark level.
unlike blood plasmacytoid dendritic cells (pDCs), a subset of tonsil pDCs express functional CCR6 (zeige CCR6 ELISA Kits) and CCR10, and their respective ligands CCL20 (zeige CCL20 ELISA Kits) and CCL27 (zeige CCL27 ELISA Kits) are detected in inflamed epithelia
The high fraction of circulating IgA (zeige IgA ELISA Kits)+ and IgG+ B cells expressing CCR9 (zeige CCR9 ELISA Kits) and CCR10 in the first months of life indicates activation of naive B cells in the gut (zeige GUSB ELISA Kits), coinciding with bacterial colonization.
TLR2 ligands induce CCR9 (zeige CCR9 ELISA Kits) and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain (zeige IGJ ELISA Kits) and IgA (zeige IgA ELISA Kits) production demonstrating the induction of mucosal-like antibody secreting cells.
CCR10 and its ligand CCL27 (zeige CCL27 ELISA Kits) may contribute to the skin infiltration of malignant T-cells in cutaneous T-cell lymphoma.
this study shows that losartan and dexamethasone may suppress inflammatory responses in IgA (zeige IgA ELISA Kits) nephropathy by inhibiting CCR10 expression in Th22 cells
Our in vivo analysis demonstrated that uniform expression of Ccr10 on MSCs and alteration of Ccl27 (zeige CCL27 ELISA Kits) level in the skin enhance extravasation of stem cells from circulation and facilitate their migration within cutaneous tissue
These findings provide definite evidence that CCR10 is important in skin intraepithelial Vgamma3(+) T lymphocyte development
Blocking CCR4 (zeige CCR4 ELISA Kits) and CCR10 simultaneously, or their ligands, should be beneficial in the treatment of T-cell-mediated skin diseases.
CCR10 is critical for efficient localization and accumulation of immunoglobulin A antibody-secreting cells to the lactating mammary gland.
Study showed bovine CCL28 mediating cellular chemotaxis via CCR10 chemokine receptor.
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues\; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27\; MIM 604833)\; CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002
, C-C chemokine receptor type 10
, CC chemokine receptor 10
, G protein-coupled receptor 2
, G-protein coupled receptor 2
, chemokine C-C receptor 9
, chemokine C-C motif receptor 10
, LOW QUALITY PROTEIN: C-C chemokine receptor type 10