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CCR1 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors.
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Results reveal that CCR1 expression is positively correlated with OPN expression in hepatocellular carcinoma cells, and the patients with high levels of both OPN and CCR1 have the most dismal prognosis. Study also, shows that steopontin upregulates CCR1 in HCC cells and, that CCR1 is essential for osteopontin-induced HCC metastasis.
Expression of CCR1 was measured in retrospective clinical specimens of colorectal cancer lung metastases. CCR1+ cells accumulated around the CCL15 (zeige CCL15 ELISA Kits)-positive colorectal cancer cells in the lung, but few around the CCL15 (zeige CCL15 ELISA Kits)-negative ones.
during renal transplantation, CD4+ and CD8+ T cells expressing CCR1 were increased in patients who developed renal allograft dysfunction
MIP-1alpha (zeige CCL3 ELISA Kits) receptor antagonism can significantly reduce T cell migration to the secreted factors from Oesophagogastric adenocarcinoma omentum and liver.
These data suggest that CCR1/CCR2B (zeige CCR2 ELISA Kits) could be involved in clearing EBV-infected latency III B cells in immunocompetent individuals via directing the migration of these cells and attracting the chemokines-expressing immune cells.
Data suggest that the interplay between CCR1 upregulation and inactivation of CXCR4 (zeige CXCR4 ELISA Kits) signaling (the CCR1/CXCR4 (zeige CXCR4 ELISA Kits) axis) drives the egress of multiple myeloma PCs from the bone marrow, leading to disease dissemination.
Basophil migration into skin lesions of Systemic Lupus Erythematosus patients were observed, but not in normal skin tissue. This migration was related to the upregulation of chemokine receptors CCR1 and CCR2 on basophils.
Study indicates that two distinct micro-environmental factors, CD40L (zeige CD40LG ELISA Kits) and Mphis, signal via CCR1 to induce AKT (zeige AKT1 ELISA Kits) activation resulting in translational stabilization of MCL-1 (zeige MCL1 ELISA Kits), and hence can contribute to CLL cell survival.
CCL15 activation of CCR1 plays critical roles in hepatocellular carcinoma metastasis.
CCL15-positive primary colorectal cancers recruited approximately 2.2 times more numbers of CCR1(+) cells.
The enhanced presence of CCL3 can explain the immediate analgesic effects, independent from an anti-inflammatory action, evoked by the administration of the CCR1 antagonist J113863 in carrageenan- and complete Freund's adjuvant inflamed mice.
Inhibition of CCR1, the distal part of this signaling relay, may have a therapeutic impact in metastatic disease with lower toxicity than blocking upstream targets.
Data indicate that deletion or inhibition of CC chemokine receptor 1 (CCR1) decreases pain responses.
CCR1-mediated accumulation of myeloid cells in the liver microenvironment promotes mouse colon cancer metastasis.
CCR1 is required for recruitment of neutrophils during respiratory infection with modified vaccinia virus Ankara.
This study demonstrates a Tpl2 (zeige MAP3K8 ELISA Kits)-dependent mechanism for macrophage expression of select chemokine (zeige CCL1 ELISA Kits) receptors.
Ccr1 plays a critical role in the recruitment of T and mononuclear phagocyte cells to inflamed kidneys of NZB/W mice, which in turn contribute to the progression of renal injury.
CCR1.beta-arrestin-2 (zeige ARRB2 ELISA Kits) complex may be related to a potential scavenging function of the receptor, which may be important for maintenance of chemokine (zeige CCL1 ELISA Kits) gradients and receptor responsiveness in complex fields of chemokines during inflammation.
CCR1 expression by both hematopoietic and nonhematopoietic cells favors tumor aggressiveness and liver cancer metastasis development.
findings show that CCR1 is pivotal for bone remodeling induced by mechanical loading during orthodontic tooth movement and these actions depend, at least in part, on CCL3 (zeige CCL3 ELISA Kits)
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.
, C-C chemokine receptor type 1
, LD78 receptor
, RANTES receptor
, macrophage inflammatory protein 1-alpha receptor
, MIP-1 alpha R
, MIP-1 alphaR
, chemokine (C-C) receptor 1
, macrophage inflammatory protein-1 alpha receptor
, chemokine receptor