anti-CHFR Antikörper

Protein Überblick

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).

Genbezeichner und Symbole assoziert mit CHFR

• checkpoint with forkhead and ring finger domains (CHFR) Antikörper
• checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr) Antikörper
• checkpoint with forkhead and ring finger domains (Chfr) Antikörper
• checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog (chfr.L) Antikörper

• 5730484M20Rik Antikörper
• C230082M18 Antikörper
• CHFR Antikörper
• rnf116 Antikörper
• rnf196 Antikörper

Bezeichner auf Proteinebene für CHFR

E3 ubiquitin-protein ligase CHFR , RING finger protein 196 , checkpoint with forkhead and RING finger domains protein , checkpoint with forkhead and ring finger domains , e3 ubiquitin-protein ligase CHFR-like