anti-Charged Multivesicular Body Protein 2B (CHMP2B) Antikörper

CHMP2B encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. Zusätzlich bieten wir Ihnen CHMP2B Proteine (11) und CHMP2B Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CHMP2B 25978 Q9UQN3
CHMP2B 68942 Q8BJF9
CHMP2B 363720  
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Top anti-CHMP2B Antikörper auf antikoerper-online.de

Showing 10 out of 76 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Chmp2b Antibody Titration: 1.0 ug/ml Positive Control: Rat Spleen 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
€255.75
Details
Human Maus Unkonjugiert ELISA Detection limit for recombinant GST tagged CHMP2B is approximately 0.03ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
€466.81
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Human Maus Unkonjugiert ELISA Detection limit for recombinant GST tagged CHMP2B is approximately 1ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
€466.81
Details
Human Kaninchen Unkonjugiert ICC, IF, WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
€449.41
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: CHMP2B Antibody [NBP2-15887] - Sample (30 ug of whole cell lysate) A: 293T B: A431 12% SDS PAGE gel, diluted at 1:1000. Immunocytochemistry/Immunofluorescence: CHMP2B Antibody [NBP2-15887] - Immunofluorescence analysis of methanol-fixed HeLa, using antibody at 1:500 dilution. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
€457.50
Details
Human Kaninchen Unkonjugiert IF, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
€318.93
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: CHMP2B Antibody [NBP1-84482] - Staining of human cell line A-431 shows positivity in nucleus & cytoplasm. Immunohistochemistry-Paraffin: CHMP2B Antibody [NBP1-84482] - Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in subsets of lymphoid cells outside reaction centra. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
€437.50
Details
Human Kaninchen Unkonjugiert IF/ICC, IHC, WB   100 μL Anmelden zum Anzeigen 11 bis 16 Tage
€370.79
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Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cell lines, using CHMP2B antibody. 200 μL Anmelden zum Anzeigen 12 bis 14 Tage
€388.41
Details
Rind (Kuh) Kaninchen Unkonjugiert WB   50 μg Anmelden zum Anzeigen 11 bis 14 Tage
€488.35
Details

Am meisten referenzierte anti-CHMP2B Antikörper

  1. Human Polyclonal CHMP2B Primary Antibody für ICC, IF - ABIN4298008 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

Weitere Antikörper gegen CHMP2B Interaktionspartner

Human Charged Multivesicular Body Protein 2B (CHMP2B) Interaktionspartner

  1. We directly link TDP-43 loss of function toxicity to two genes with rare amyotrophic lateral sclerosis and frontotemporal lobar degeneration-causing mutations, CHMP2B and ErbB4

  2. these data indicate that the neuronal expression of human CHMP2B(intron5) in areas involved in motor and cognitive functions induces progressive motor alterations associated with dementia symptoms and with histopathological hallmarks reminiscent of both amyotrophic lateral sclerosis and frontotemporal dementia.

  3. Endogenous TMEM106B was partly sequestered in CHMP2B-positive structures. SNP T185 was more associated with CHMP2B than SNP S185, and it enhanced neurotoxicity caused by CHMP2B(Intron5) compared to S185-expressing cells.

  4. Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course

  5. Protein kinase CK2 alpha is involved in the phosphorylation of the ESCRT-III subunits CHMP3 and CHMP2B, as well as of VPS4B/SKD1, an ATPase that mediates ESCRT-III disassembly.

  6. Data indicate that knockdown of syntaxin 13 (syx13) further increased the cellular toxicity caused by muaant CHMP2B (CHMP2BIntron5) expression.

  7. CHMP2B immunoreactivity was increased in the dorsal motor nucleus of the vagus nerve in Parkinson's disease and incidental Lewy body disease brains

  8. These findings suggest that endosomal and autophagic pathway is associated with degradation or formation of alpha-synuclein aggregates in alpha-synucleinopathy.

  9. Subjects with CHMP2B mutation show cognitive changes dominated by executive dysfunctions, years before they fulfil diagnostic criteria of FTD.

  10. Direct link between disease-causing mutations and the cellular phenotype in cells originating from CHMP2B mutation patients with frontotemporal dementia.

  11. This study provided a better understanding of the cellular pathogenesis of neurodegenerative diseases associated with various missense mutations of CHMP2B as well as endocytic defects.

  12. CHMP2B polymerization scaffolds membranes in vivo represents a first step toward demonstrating its structural role during outward membrane deformation

  13. recent advances in our understanding of the molecular basis of CHMP2B mutations indicate that the mechanisms involved may be broadly relevant to neurodegenerative processes.[review]

  14. A novel heterozygous variant p.Ser194Leu (c.581C>T) is found in exon 6 of the CHMP2B gene in one male patient with pure frontotemporal lobar degeneration.

  15. The results of this study confirmed that mutations in CHMP2B are not a common cause of frontotemporal lobar degeneration.

  16. CHMP2B is required for spine growth. Taken together, these results demonstrate that a mutant ESCRT-III subunit linked to a human neurodegenerative disease can disrupt the normal pattern of spine development.

  17. analysis of CHMP2B mutations in lower motor neuron predominant amyotrophic lateral sclerosis

  18. The fusion of endosomes with lysosomes is required for neuronal function suggesting a pathogenic mechanism for frontotemporal dementia caused by CHMP2B mutations.

  19. CHMP2B can be used as a reliable marker for GVD in neurons of the AD hippocampus.

  20. there were no significant differences in the frequencies of the IVS4 + 44C/A, 1303C/A, 1254T/C and IVS15Ex16-16C/G polymorphism haplotypes in the patient cohorts (regardless of the degree of hepatic iron deposition) compared to the control cohort

CHMP2B Antigen-Profil

Protein Überblick

This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.

Genbezeichner und Symbole assoziert mit CHMP2B

  • charged multivesicular body protein 2B (CHMP2B) Antikörper
  • charged multivesicular body protein 2Ba (chmp2ba) Antikörper
  • charged multivesicular body protein 2B pseudogene (LOC747711) Antikörper
  • charged multivesicular body protein 2B (Chmp2b) Antikörper
  • charged multivesicular body protein 2Bb (chmp2bb) Antikörper
  • 1190006E07Rik Antikörper
  • ALS17 Antikörper
  • CHMP2.5 Antikörper
  • chmp2b Antikörper
  • chmp2bl Antikörper
  • DMT1 Antikörper
  • RGD1306781 Antikörper
  • si:ch211-224m9.5 Antikörper
  • VPS2-2 Antikörper
  • VPS2B Antikörper
  • zgc:77025 Antikörper

Bezeichner auf Proteinebene für CHMP2B

chromatin modifying protein 2B , charged multivesicular body protein 2b , chmp2b , chromatin-modifying protein 2b , VPS2 homolog B , vacuolar protein-sorting-associated protein 2-2 , chromatin modifying protein 2B, like

GENE ID SPEZIES
487675 Canis lupus familiaris
569532 Danio rerio
747711 Pan troglodytes
100172566 Pongo abelii
100224229 Taeniopygia guttata
25978 Homo sapiens
68942 Mus musculus
363720 Rattus norvegicus
615954 Bos taurus
418461 Gallus gallus
100516044 Sus scrofa
405840 Danio rerio
Ausgewählte Anbieter für anti-CHMP2B (CHMP2B) Antikörper
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