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The protein encoded by CCT6A is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC).
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High expression of CCT6A is associated with Non-Small Cell Lung Cancer.
selective inhibition of SMAD3 (zeige SMAD3 ELISA Kits) or CCT6A efficiently suppresses TGF-beta (zeige TGFB1 ELISA Kits)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (zeige TGFB1 ELISA Kits) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (zeige TGFB1 ELISA Kits) for non-small-cell lung carcinoma.
These data suggest that CCT6A is a novel autoantigen recognized by Vdelta2 gammadelta T cells, which deepens our understanding of mechanisms in autoimmune diseases.
identified genes, which include Tcp20, may play important role in conferring radioresistance to oral squamous cell carcinoma and could be useful in identifying cases with more radioresistance
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located.
chaperonin containing TCP1, subunit 6A (zeta 1)
, T-complex protein 1 subunit zeta
, chaperonin containing TCP1, subunit 6A-like
, T-complex protein 1 subunit zeta-like
, T-complex protein 1, zeta subunit
, acute morphine dependence related protein 2
, acute morphine dependence-related protein 2
, amino acid transport defect-complementing
, chaperonin containing T-complex subunit 6
, histidine transport regulator 3
, chaperonin subunit 6a (zeta)
, chaperonin Cct6
, chaperonin containing TCP1, subunit 6B (zeta 2)
, chaperonin containing TCP-1