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The protein encoded by CCT5 is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). Zusätzlich bieten wir Ihnen CCT5 Antikörper (84) und CCT5 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex
H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5.
Both CCT4 and CCT5 homo-oligomers have the property of forming 8-fold double rings absent the other subunits, and these complexes carry out chaperonin reactions without other partner subunits.
introduction of the truncated human CCT epsilon subunit into yeast cells
A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia.
mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel.
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three pseudogenes of this gene have been identified.
T-complex protein 1 subunit epsilon
, T-complex protein 1, epsilon subunit
, chaperonin subunit 5 (epsilon)
, TCP-1 epsilon
, chaperonin containing TCP1, subunit 5 (epsilon)
, chaperonin containing TCP1, subunit 5 (epsilon) a
, T-complex protein 1 subunit epsilon-like
, t-complex protein 1 subunit epsilon-like