Cereblon (CRBN) ELISA Kits

CRBN encodes a protein related to the Lon protease protein family. Zusätzlich bieten wir Ihnen Cereblon Antikörper (38) und Cereblon Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
CRBN 297498 Q56AP7
CRBN 51185 Q96SW2
CRBN 58799 Q8C7D2
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Top Cereblon ELISA Kits auf antikoerper-online.de

Showing 5 out of 22 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.057 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$589.47
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Maus 0.057 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$606.32
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Ratte
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,029.60
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Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,029.60
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Huhn
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,095.60
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Weitere ELISA Kits für Cereblon Interaktionspartner

Human Cereblon (CRBN) Interaktionspartner

  1. we identify Rabex-5 (zeige RABGEF1 ELISA Kits) as a Immunomodulatory drugs (IMiDs) target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 (zeige RABGEF1 ELISA Kits) from complex with Cereblon enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs.

  2. We sequenced CRBN-thalidomide binding region in 38 thalidomide embryopathy individuals and 136 Brazilians without congenital anomalies, and performed in silico analyses. Eight variants were identified, seven intronic and one in 3'UTR (zeige UTS2R ELISA Kits).

  3. These findings thus contribute to a growing list of ID disorders caused by CRBN mutations, broaden the spectrum of phenotypes attributable to Autosomal-recessive non-syndromic intellectual disability (ARNS-ID)and provide new insight into genotype-phenotype correlations between CRBN mutations and the aetiology of ARNS-ID.

  4. CRBN expression is of prognostic value in MM patients ineligible for ASCT treated with thalidomide as an immunomodulatory drug. With low expression indicating a possible suboptimal treatment outcome, measurement of CRBN expression might serve as additional prognostic tool in the personalized treatment approach.

  5. Plasmablast differentiation, whether induced by BAFF (zeige TNFSF13B ELISA Kits) or CD40L (zeige CD40LG ELISA Kits), is prevented by modulation of CRBN activity with CC-220, which induces degradation of the B cell differentiation factors Aiolos (zeige IKZF3 ELISA Kits) and Ikaros (zeige IKZF1 ELISA Kits). Downregulation of these B cell differentiation processes by CC-220 modulation of CRBN provides a new therapeutic approach to treating B cell-mediated pathology in SLE.

  6. High CRBN expression is associated with multiple myeloma.

  7. CRBN negatively regulates TLR4 (zeige TLR4 ELISA Kits) signaling via attenuation of TRAF6 (zeige TRAF6 ELISA Kits) and TAB2 (zeige TAB2 ELISA Kits) ubiquitination.

  8. Compared with newly diagnosed multiple myeloma, an increased prevalence of mutations in the Ras pathway genes KRAS, NRAS (zeige NRAS ELISA Kits), and/or BRAF (zeige BRAF ELISA Kits) (72%), as well as TP53 (zeige TP53 ELISA Kits) (26%), CRBN (12%), and CRBN pathway genes (10%) was observed.

  9. results suggest that CRBN binds to Ikaros (zeige IKZF1 ELISA Kits) via its N-terminal region and regulates transcriptional activities of Ikaros (zeige IKZF1 ELISA Kits) and its downstream target, enkephalin

  10. dual assay demonstrated superior Cereblon IHC measurement in MM samples compared with the single IHC assay using a published commercial rabbit polyclonal Cereblon antibody and could be used to explore the potential utility of Cereblon as a biomarker in the clinic

Mouse (Murine) Cereblon (CRBN) Interaktionspartner

  1. Collectively, our data suggested that CRBN is a potential treatment option against diabetes-induced osteolytic bone disease.

  2. Data show that cereblon (CRBN) limits CD4 (zeige CD4 ELISA Kits)(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (Kv1.3) expression.

  3. CRBN negatively regulates TLR4 (zeige TLR4 ELISA Kits) signaling via attenuation of TRAF6 (zeige TRAF6 ELISA Kits) and TAB2 (zeige TAB2 ELISA Kits) ubiquitination.

  4. CRBN is involved in the activation of PERK (zeige EIF2AK3 ELISA Kits) and the Ire1 (zeige ERN1 ELISA Kits) pathway of the unfolded protein response.CRBN plays a role in cellular stress signaling, including the unfolded protein response, by controlling the activity of AMPK (zeige PRKAA1 ELISA Kits).

  5. results of this study suggest a plausible mechanism for CRBN involvement in higher brain function in humans, and they may help explain how a specific mutation in CRBN can affect the cognitive ability of patients

  6. Found significantly smaller infarct sizes and less fibrosis in the hearts of CRBN KO mice than in those of WT mice. Apoptosis was also significantly reduced in the KO mice compared with that in WT mice.

  7. findings suggest that crbn-/- mice exhibit selective HPC-dependent deficits in associative learning.

  8. CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK (zeige PRKAA2 ELISA Kits) alpha1) and inhibits the activation of AMPK (zeige PRKAA1 ELISA Kits) activation.

  9. These results imply that Nrf2 (zeige NFE2L2 ELISA Kits) stimulates CRBN gene transcription under hypoxia-reoxygenation conditions in neuronal cells.

Cereblon (CRBN) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit Cereblon (CRBN) ELISA Kits

  • cereblon (crbn) Antikörper
  • cereblon (CRBN) Antikörper
  • ATP-dependent protease La (LON) domain protein (AT2G25740) Antikörper
  • cereblon (Crbn) Antikörper
  • 2610203G15Rik Antikörper
  • 2900045O07Rik Antikörper
  • AF229032 Antikörper
  • AW108261 Antikörper
  • F3N11.21 Antikörper
  • MRT2 Antikörper
  • MRT2A Antikörper
  • piL Antikörper
  • zgc:92404 Antikörper

Bezeichner auf Proteinebene für Cereblon (CRBN) ELISA Kits

protein cereblon , zcrbn , cereblon , protein cereblon-like , protein x 0001 , novel lethal , protein PiL , Protein cereblon

GENE ID SPEZIES
445491 Danio rerio
100052958 Equus caballus
704436 Macaca mulatta
460130 Pan troglodytes
493554 Xenopus (Silurana) tropicalis
100022278 Monodelphis domestica
100479474 Ailuropoda melanoleuca
817117 Arabidopsis thaliana
100584605 Nomascus leucogenys
297498 Rattus norvegicus
51185 Homo sapiens
58799 Mus musculus
511585 Bos taurus
416104 Gallus gallus
476551 Canis lupus familiaris
100174633 Pongo abelii
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