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CRBN encodes a protein related to the Lon protease protein family. Zusätzlich bieten wir Ihnen Cereblon Antikörper (38) und Cereblon Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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we identify Rabex-5 (zeige RABGEF1 ELISA Kits) as a Immunomodulatory drugs (IMiDs) target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 (zeige RABGEF1 ELISA Kits) from complex with Cereblon enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs.
We sequenced CRBN-thalidomide binding region in 38 thalidomide embryopathy individuals and 136 Brazilians without congenital anomalies, and performed in silico analyses. Eight variants were identified, seven intronic and one in 3'UTR (zeige UTS2R ELISA Kits).
These findings thus contribute to a growing list of ID disorders caused by CRBN mutations, broaden the spectrum of phenotypes attributable to Autosomal-recessive non-syndromic intellectual disability (ARNS-ID)and provide new insight into genotype-phenotype correlations between CRBN mutations and the aetiology of ARNS-ID.
CRBN expression is of prognostic value in MM patients ineligible for ASCT treated with thalidomide as an immunomodulatory drug. With low expression indicating a possible suboptimal treatment outcome, measurement of CRBN expression might serve as additional prognostic tool in the personalized treatment approach.
Plasmablast differentiation, whether induced by BAFF (zeige TNFSF13B ELISA Kits) or CD40L (zeige CD40LG ELISA Kits), is prevented by modulation of CRBN activity with CC-220, which induces degradation of the B cell differentiation factors Aiolos (zeige IKZF3 ELISA Kits) and Ikaros (zeige IKZF1 ELISA Kits). Downregulation of these B cell differentiation processes by CC-220 modulation of CRBN provides a new therapeutic approach to treating B cell-mediated pathology in SLE.
High CRBN expression is associated with multiple myeloma.
CRBN negatively regulates TLR4 (zeige TLR4 ELISA Kits) signaling via attenuation of TRAF6 (zeige TRAF6 ELISA Kits) and TAB2 (zeige TAB2 ELISA Kits) ubiquitination.
Compared with newly diagnosed multiple myeloma, an increased prevalence of mutations in the Ras pathway genes KRAS, NRAS (zeige NRAS ELISA Kits), and/or BRAF (zeige BRAF ELISA Kits) (72%), as well as TP53 (zeige TP53 ELISA Kits) (26%), CRBN (12%), and CRBN pathway genes (10%) was observed.
results suggest that CRBN binds to Ikaros (zeige IKZF1 ELISA Kits) via its N-terminal region and regulates transcriptional activities of Ikaros (zeige IKZF1 ELISA Kits) and its downstream target, enkephalin
dual assay demonstrated superior Cereblon IHC measurement in MM samples compared with the single IHC assay using a published commercial rabbit polyclonal Cereblon antibody and could be used to explore the potential utility of Cereblon as a biomarker in the clinic
Collectively, our data suggested that CRBN is a potential treatment option against diabetes-induced osteolytic bone disease.
Data show that cereblon (CRBN) limits CD4 (zeige CD4 ELISA Kits)(+) T-cell activation via epigenetic regulation of Kv1.3 potassium channel (Kv1.3) expression.
CRBN is involved in the activation of PERK (zeige EIF2AK3 ELISA Kits) and the Ire1 (zeige ERN1 ELISA Kits) pathway of the unfolded protein response.CRBN plays a role in cellular stress signaling, including the unfolded protein response, by controlling the activity of AMPK (zeige PRKAA1 ELISA Kits).
results of this study suggest a plausible mechanism for CRBN involvement in higher brain function in humans, and they may help explain how a specific mutation in CRBN can affect the cognitive ability of patients
Found significantly smaller infarct sizes and less fibrosis in the hearts of CRBN KO mice than in those of WT mice. Apoptosis was also significantly reduced in the KO mice compared with that in WT mice.
findings suggest that crbn-/- mice exhibit selective HPC-dependent deficits in associative learning.
CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK (zeige PRKAA2 ELISA Kits) alpha1) and inhibits the activation of AMPK (zeige PRKAA1 ELISA Kits) activation.
These results imply that Nrf2 (zeige NFE2L2 ELISA Kits) stimulates CRBN gene transcription under hypoxia-reoxygenation conditions in neuronal cells.
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
, protein cereblon-like
, protein x 0001
, novel lethal
, protein PiL
, Protein cereblon