Ceramide Synthase 2 Proteine (CERS2)

CERS2 encodes a protein that has sequence similarity to yeast longevity assurance gene 1.

alle Proteine anzeigen Gen GeneID UniProt
Human CERS2 CERS2 29956 Q96G23
Maus CERS2 CERS2 76893 Q924Z4
Ratte CERS2 CERS2 310667  
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,649.05
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,616.87
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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Weitere Proteine zu Ceramide Synthase 2 (CERS2) Interaktionspartnern

Human Ceramide Synthase 2 (CERS2) Interaktionspartner

  1. CerS2-knockdown via CRISPR-Cas9 technology in cultured colon epithelial cells impaired barrier function.

  2. Low expression of LASS2 and TGFB1 (zeige TGFB1 Proteine) contributes to the aggressiveness and poor prognosis of hepatocellular carcinoma, and may represent a novel prognostic biomarker for hepatocellular carcinoma patients.

  3. ASGR1 (zeige ASGR1 Proteine) can inhibit the activity of V-ATPase (zeige ATP6V1H Proteine) by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells.

  4. Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) inhibit cell growth by regulating expression of KLF4/LASS2/V-ATPase proteins in breast cancer.

  5. these results indicate that miR (zeige MLXIP Proteine)-9 upregulation might be associated with malignant phenotype of bladder cancer. miR (zeige MLXIP Proteine)-9 promotes chemoresistance of bladder cancer cells by target LASS2.

  6. Data show that CERS2 expression was markedly different between various breast cancer cells and inversely correlated with cell invasion.

  7. silencing of TMSG1 increased V-ATPase (zeige ATP6V1H Proteine) activity, decreased extracellular pH and in turn the activation of secreted MMP-2 (zeige MMP2 Proteine), which ultimately promoted metastasis capacity of breast cancer cell.

  8. Results confirmed that TMSG1 is a potential metastasis suppressor gene, and suggested that the mechanism involved the induction of apoptosis and inhibition of cell proliferation via a caspase (zeige CASP3 Proteine)-dependent mitochondrial pathway.

  9. the vacuolar ATPase (V-ATPase) activity and extracellular hydrogen ion concentration were significantly decreased and the activity of secreted matrix metalloproteinase-2 (MMP-2 (zeige MMP2 Proteine)) was downregulated in MCF-7 cells overexpressing LASS2/TMSG1

  10. the inhibitory effect of the LASS2 on growth, invasion and metastasis of prostate cancer cells

Mouse (Murine) Ceramide Synthase 2 (CERS2) Interaktionspartner

  1. Deficiency of CerS2 influences intestinal barrier function and the severity of experimental colitis and may represent a potential mechanism for inflammatory bowel disease pathogenesis.

  2. LASS2 plays an important role in efficient liver regeneration in response to partial hepatectomy.

  3. Deletion of CerS2 strongly reduced very long-chain ceramides (Cer24:0, 24:1) but concomitantly increased long-chain ceramides and sphinganine in plasma and colon tissue. In naive CerS2(-/-) mice, the expression of tight junction proteins including ZO-1 (zeige TJP1 Proteine) was almost completely lost in the colon epithelium, leading to increased membrane permeability. Ceramide synthase 2 deficiency aggravates dextran induced colitis in mice.

  4. this study shows that Cers2 limits the levels of S1P (zeige S1PR1 Proteine) in thymus and blood to maintain functional S1P (zeige S1PR1 Proteine) gradients that mediate thymocyte emigration into the circulation

  5. that only LCBs, the substrates common for all of the CerS isoforms, but not ceramides and complex sphingolipids, were restored to the wild-type levels in the Cers2-rescued Cers1 (zeige CERS1 Proteine) mutant mouse brains.

  6. CerS1 (zeige CERS1 Proteine), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (zeige SIRT3 Proteine)-null mice.

  7. Haploinsufficiency for this enzyme altered the pattern of ceramide acylation in the liver without affecting total ceramide levels, replacing very-long-chain ceramides with long-chain C16-ceramides.

  8. Development of pheochromocytoma in ceramide synthase 2 null mice

  9. our data strongly indicate that G-CSF (zeige CSF3 Proteine)-induced CXCR2 (zeige CXCR2 Proteine) expression is regulated in a CerS2-dependent manner and that CerS2 thereby promotes the migration of neutrophils, thus, contributing to inflammation and the development of EAE and MS.

  10. Data indicate that the augmented rate of death of ceramide synthase 2 (CerS2) null mice is due to elevated levels of tumor necrosis factor alpha (TNFalpha (zeige TNF Proteine)) secretion as a result of enhanced activity of TNFalpha (zeige TNF Proteine)-converting enzyme (TACE (zeige ADAM17 Proteine)).

Ceramide Synthase 2 (CERS2) Protein Überblick

Protein Überblick

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.

Genbezeichner und Symbole assoziert mit Ceramide Synthase 2 Proteine (CERS2)

  • ceramide synthase 2 (CERS2)
  • ceramide synthase 2 (Cers2)
  • 0610013I17Rik Protein
  • AI225939 Protein
  • L3 Protein
  • Lass2 Protein
  • SP260 Protein
  • TMSG1 Protein
  • TRH3 Protein

Bezeichner auf Proteinebene für Ceramide Synthase 2 Proteine (CERS2)

LAG1 homolog, ceramide synthase 2 , LAG1 longevity assurance 2 , longevity assurance (LAG1, S. cerevisiae) homolog 2 , tumor metastasis-suppressor gene 1 protein , LAG1 longevity assurance homolog 2 , TRAM homolog 3 , longevity assurance homolog 2 , translocating chain-associating membrane protein homolog 3

GENE ID SPEZIES
100055037 Equus caballus
29956 Homo sapiens
483187 Canis lupus familiaris
539223 Bos taurus
76893 Mus musculus
310667 Rattus norvegicus
100156737 Sus scrofa
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