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CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite.
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these studies demonstrate a novel requirement for the CERK-derived C1P in the proper healing response of wounds.
there are significant differences in eicosanoid levels in ex vivo CERK(-/-) cells compared with wild-type counterparts, but the effect of the genetic ablation of CERK on eicosanoid synthesis and the serum levels of C1P was not apparent in vivo
role of ceramide kinase in obesity and insulin (zeige INS Proteine) resistance
Results indicate that C1P produced by CERK has a negative effect on the processing/secretion of TNFalpha (zeige TNF Proteine) via modulation of TACE (zeige ADAM17 Proteine) activity.
role of CerK on the activation of mast cells
The mechanism of ceramide-mediated inhibition is likely to involve conversion of ceramide to ceramide 1-phosphate by CERK.
LPS (zeige TLR4 Proteine) inhibits the transcriptional activity of the Cerk proximal promoter;transcriptional repression of Cerk by LPS (zeige TLR4 Proteine) is not a primary consequence of LPS (zeige TLR4 Proteine)-induced cell cycle blockade.
Findings suggest that CerK is not necessary for survival at an individual level, but might be involved in higher brain function related to emotion.
CerK is essential to ceramide 1-phosphate formation via phosphorylation of Cer (zeige CBLN1 Proteine)
Ceramide kinase is a key regulator of ceramide 1-phosphate, dihydroceramide and ceramide levels, with important implications for neutrophil homeostasis and innate immunity regulation.
our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway.
Data suggest that inhibition of ceramide kinase (CerK) [by specific gene silencing or pharmacological inhibition] drastically reduced cell proliferation in a neuroblastoma (zeige ARHGEF16 Proteine) cell line.
TNF-alpha (zeige TNF Proteine) exposure of human SH-SY5Y neuroblastoma (zeige ARHGEF16 Proteine) caused a profound increase in CERK activity.
Expression of hCERK enhanced ceramide-1-phosphate formation and release of arachidonic acid in Ca(2 (zeige CA2 Proteine)+) ionophore-stimulated cells.
We have identified a differential role for ceramide kinase in mast-cell activation
ceramide kinase and its product, C-1-P, have roles in arachidonic acid release and production of eicosanoids
CERK translocates during activation from the cytosol to a lipid raft fraction
Pleckstrin (zeige PLEK Proteine) homology domain of CERK is not only indispensable for its activity but also act as a regulator of CERK activity.
sphingoid chain was also required for substrate recognition by CERK
Recombinant CERK was analyzed with regard to dependence on divalent cations, to substrate delivery, specificity, and stereoselectivity. CERK associated with the plasma membrane in CHO (zeige COL11A1 Proteine) cells, which is mediated by the N-terminal putative pleckstrin (zeige PLEK Proteine) domain.
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006
, lipid kinase 4
, lipid kinase LK4
, ceramide kinase
, Ceramide kinase