Ceramide Kinase Proteine (CERK)

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Zusätzlich bieten wir Ihnen CERK Antikörper (94) und CERK Kits (14) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CERK 223753 Q8K4Q7
Ratte CERK CERK 300129  
CERK 64781 Q8TCT0
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage

CERK Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,

Weitere Proteine zu Ceramide Kinase (CERK) Interaktionspartnern

Mouse (Murine) Ceramide Kinase (CERK) Interaktionspartner

  1. The depletion of CerK enhances the pathology of colitis and lethal responses in DSS-treated mice.

  2. these studies demonstrate a novel requirement for the CERK-derived C1P in the proper healing response of wounds.

  3. there are significant differences in eicosanoid levels in ex vivo CERK(-/-) cells compared with wild-type counterparts, but the effect of the genetic ablation of CERK on eicosanoid synthesis and the serum levels of C1P was not apparent in vivo

  4. role of ceramide kinase in obesity and insulin resistance

  5. Results indicate that C1P produced by CERK has a negative effect on the processing/secretion of TNFalpha via modulation of TACE activity.

  6. role of CerK on the activation of mast cells

  7. The mechanism of ceramide-mediated inhibition is likely to involve conversion of ceramide to ceramide 1-phosphate by CERK.

  8. LPS inhibits the transcriptional activity of the Cerk proximal promoter;transcriptional repression of Cerk by LPS is not a primary consequence of LPS-induced cell cycle blockade.

  9. Findings suggest that CerK is not necessary for survival at an individual level, but might be involved in higher brain function related to emotion.

  10. CerK is essential to ceramide 1-phosphate formation via phosphorylation of Cer

  11. Ceramide kinase is a key regulator of ceramide 1-phosphate, dihydroceramide and ceramide levels, with important implications for neutrophil homeostasis and innate immunity regulation.

Human Ceramide Kinase (CERK) Interaktionspartner

  1. our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway.

  2. Data suggest that inhibition of ceramide kinase (CerK) [by specific gene silencing or pharmacological inhibition] drastically reduced cell proliferation in a neuroblastoma cell line.

  3. TNF-alpha exposure of human SH-SY5Y neuroblastoma caused a profound increase in CERK activity.

  4. Expression of hCERK enhanced ceramide-1-phosphate formation and release of arachidonic acid in Ca(2+) ionophore-stimulated cells.

  5. We have identified a differential role for ceramide kinase in mast-cell activation

  6. Molecular cloning and functional characterization

  7. ceramide kinase and its product, C-1-P, have roles in arachidonic acid release and production of eicosanoids

  8. CERK translocates during activation from the cytosol to a lipid raft fraction

  9. Pleckstrin homology domain of CERK is not only indispensable for its activity but also act as a regulator of CERK activity.

  10. sphingoid chain was also required for substrate recognition by CERK

  11. Recombinant CERK was analyzed with regard to dependence on divalent cations, to substrate delivery, specificity, and stereoselectivity. CERK associated with the plasma membrane in CHO cells, which is mediated by the N-terminal putative pleckstrin domain.

  12. CERK-pleckstrin homology domain plays a crucial role in plasma membrane targeting through its binding to phosphatidylinositol 4,5-bisphosphate and subsequent induction of ceramide-1-phosphate production in the vicinity of the membrane.

  13. These results suggest that ceramide kinase determines the balance between pro-apoptotic ceramide and anti-apoptotic C1P to regulate cell fate, reminiscent of its function in plants.

  14. Results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT.

  15. HL-60 cells are useful for studying CerK functions in leukocyte differentiation, and they also suggest that CerK might have an important role in such differentiation.

  16. higher Ca2+ signal observed in hCERK transfected cells as well as the fact that CERK colocalized with EIgG during phagocytosis support hypothesis that Ca2+ signaling is an important factor for increasing phagocytosis and is regulated by CERK

  17. identification of a cluster of cysteines, C(347)XXXC(351)XXC(354), essential for CerK function

  18. ceramide kinase, was associated with poor pathohistological grading in breast cancer

  19. The Pleckstrin Homology (PH) domain of CERK, which is required for Golgi complex localization, can substitute for the N-terminal region of CERKL and allow for wild-type CERKL localization, which is typified by nucleolar accumulation.

  20. JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2

CERK Protein Überblick

Protein Überblick

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006

Genbezeichner und Symbole assoziert mit Ceramide Kinase Proteine (CERK)

  • ceramide kinase (Cerk)
  • ceramide kinase (CERK)
  • ceramide kinase (cerk)
  • ceramide kinase S homeolog (cerk.S)
  • ceramide kinase (CpipJ_CPIJ003342)
  • ceramide kinase (LOAG_11245)
  • Ceramide kinase (Cerk)
  • ceramide kinase (LOC5579301)
  • Ceramide kinase (Bm1_50005)
  • AI848610 Protein
  • CERK Protein
  • CG16708 Protein
  • D330016D08Rik Protein
  • dA59H18.2 Protein
  • dA59H18.3 Protein
  • dcerk Protein
  • Dmel\\CG16708 Protein
  • hCERK Protein
  • LK4 Protein
  • MGC81777 Protein
  • mKIAA1646 Protein
  • si:ch211-162i19.1 Protein

Bezeichner auf Proteinebene für Ceramide Kinase Proteine (CERK)

acylsphingosine kinase , mCERK , lipid kinase 4 , lipid kinase LK4 , ceramide kinase , CG16708-PA , CG16708-PB , Cerk-PA , Cerk-PB , Ceramide kinase

223753 Mus musculus
300129 Rattus norvegicus
64781 Homo sapiens
474464 Canis lupus familiaris
100053604 Equus caballus
458921 Pan troglodytes
425523 Gallus gallus
558496 Danio rerio
444466 Xenopus laevis
6034795 Culex quinquefasciatus
9948698 Loa loa
40640 Drosophila melanogaster
5579301 Aedes aegypti
6104885 Brugia malayi
100336737 Bos taurus
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