anti-Cell Death-Inducing DFFA-Like Effector C (CIDEC) Antikörper

Cow (Bovine) Cell Death-Inducing DFFA-Like Effector C (CIDEC) Interaktionspartner

1. CIDEC may affect body measurement traits and meat quality traits in Qinchuan cattle, and could be used in marker-assisted selection.

2. This paper examined the tissue expression profile of CIDEC gene in cattle.

Human Cell Death-Inducing DFFA-Like Effector C (CIDEC) Interaktionspartner

1. FTO (zeige FTO Antikörper) increased the lipid accumulation in hepatocytes by increasing nuclear translocation of SREBP1c (zeige SREBF1 Antikörper) and SREBP1c (zeige SREBF1 Antikörper) maturation, thus improving the transcriptional activity of lipid droplet-associated protein (zeige PLIN1 Antikörper) CIDEC.

2. this study has indicated that 3' UTR (zeige UTS2R Antikörper) variation in CIDEC is associated with the risk of elevated fasting glucose, the progression of hypertriglyceridemia and hypertension, and the efficacy of angiotensin II-targeted antihypertensive agents.

3. Two tissue-specific CIDEc isoforms had different roles in lipid deposition.

4. data suggested that Cidec could interact with and down-regulate AMPKalpha (zeige GRK4 Antikörper) through an ubiquitin-proteasome degradation pathway, which provided a possible mechanism of Cidec in promoting human adipocytes differentiation

5. Hepatic expression of FSP27/CIDEC is highly up-regulated in in patients with alcoholic steatohepatitis and this up-regulation contributes to alcohol-induced liver damage.

6. It is insinuated that VAT is associated with late phase obesity CIDEC decrease and insulin (zeige INS Antikörper) resistance, while pioglitazone enhances CIDEC through activation of PPAR-gamma (zeige PPARG Antikörper), increases its expression, and decreases lipolysis.

7. After bariatric surgery-induced weight loss, CIDEC/FSP27 gene/protein expression in SAT increased significantly. Findings suggest a positive functional interaction between CIDEC/FSP27 & mitochondrial biogenesis-related genes in human adipose tissue

8. Data indicate that fat-specific protein 27 (FSP27) increases the inhibitory effect of transcription factor Egr1 (zeige EGR1 Antikörper) on the adipose triglyceride lipase (ATGL (zeige PNPLA2 Antikörper)) promoter.

9. results demonstrate a crucial role for FSP27-ATGL (zeige PNPLA2 Antikörper) interactions in regulating lipolysis, triglyceride accumulation, and insulin (zeige INS Antikörper) signaling in human adipocytes

10. homo-dimeric structure of the CIDE-N domain of FSP27 will provide important information that will enable better understanding of the function of FSP27.

Mouse (Murine) Cell Death-Inducing DFFA-Like Effector C (CIDEC) Interaktionspartner

1. the role of gp78 (zeige AMFR Antikörper) and cidec in hepatic steatosis, were investigated.

2. The current study demonstrated that insulin (zeige INS Antikörper) represses fasting-induced (zeige C10orf10 Antikörper) Fsp27 expression in the liver. The Fsp27 decreased by insulin (zeige INS Antikörper) is likely to cause the lower fat accumulation in liver.

3. Fatty acids prevent CIDEC deacetylation by promoting the dissociation of CIDEC from HDAC6 (zeige HDAC6 Antikörper), resultin in increased association of CIDEC with PCAF (zeige KAT2B Antikörper) on the endoplasmic reticulum.

4. We show that partial silencing Fsp27 in either model results in the robust decrease in visceral fat, improved insulin (zeige INS Antikörper) sensitivity and whole-body glycemic control, and tissue-specific changes in transcripts controlling lipid oxidation and synthesis

5. results suggest that FSP27beta negatively regulates CideA (zeige CIDEA Antikörper)-promoted enlargement of lipid droplet size in brown adipocytes.

6. Lipid droplet (LD) expansion depends on the FSP27 carboxy-terminal domain (amino acids 131-239). The negative charge of acidic residues D215, E218, E219 and E220 in the polar carboxy-terminal region (amino acids 202-239) is essential for LD enlargement.

7. Data (including data from studies in knockout mice) suggest Cideb (zeige CIDEB Antikörper) promotes lipid storage as droplets in hepatocytes under normal diet conditions; Cidea (zeige CIDEA Antikörper)/Cidec promote fusion of lipid droplets leading to liver steatosis in fasting (16h) and obese mice.

8. Cidea (zeige CIDEA Antikörper) is highly associated with adiposity and insulin (zeige INS Antikörper) resistance, whereas Cidec is related to insulin (zeige INS Antikörper) sensitivity

9. Hepatic expression of FSP27/CIDEC is highly up-regulated in mice following chronic-plus-binge ethanol feeding and this up-regulation contributes to alcohol-induced liver damage.

10. Insulin (zeige INS Antikörper) resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice.

Pig (Porcine) Cell Death-Inducing DFFA-Like Effector C (CIDEC) Interaktionspartner

1. CIDEC protects lipid droplets (LDs) by decreasing the specific surface area of LDs and is involved in the regulation of hepatic lipid deposition.

2. CIDEa (zeige CIDEA Antikörper) and CIDEc mRNA level in white adipose tissues and liver were significantly higher in obese pigs than in their lean counterparts