Cell Death-Inducing DFFA-Like Effector A Proteine (CIDEA)

CIDEA encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. Zusätzlich bieten wir Ihnen CIDEA Antikörper (100) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CIDEA 1149 O60543
CIDEA 12683 O70302
Ratte CIDEA CIDEA 291541  
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Escherichia coli (E. coli) Maus His tag,T7 tag 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$440.00
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$221.48
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Escherichia coli (E. coli) Human His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$749.00
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CIDEA Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)
,

Weitere Proteine zu Cell Death-Inducing DFFA-Like Effector A (CIDEA) Interaktionspartnern

Human Cell Death-Inducing DFFA-Like Effector A (CIDEA) Interaktionspartner

  1. Cidea, unexpectedly, functions molecularly as an indirect inhibitor of thermogenesis via inhibition of UCP1 activity.

  2. These data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.

  3. Since Cide-A protein plays a role in the development of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and their vascular complications, CIDE -A gene and protein are potential therapeutic targets for these diseases.

  4. The lowest mean relative of the gene expression for CIDE-A was observed in the group of obese patients with aortic aneurysm and lipid disorders

  5. the association of tag-single nucleotide polymorphisms and haplotype structures of the CIDEA gene with obesity in a Han Chinese population, was investigated.

  6. CIDE proteins expression correlate with tumor and survival characteristics in patients with renal cell carcinoma.

  7. Insulin regulates CIDEA and CIDEC expression via PI3K, and it regulates expression of each protein via Akt1/2-and JNK2-dependent pathways, respectively, in human adipocytes.

  8. The proportion of subjects with CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population was significantly higher based on genotype, in the order: GG

  9. CIDEA binds to liver X receptors and regulates their activity in vitro.

  10. These data indicate that the carboxy-terminal domain of Cidea directs lipid droplet targeting, lipid droplet clustering, and triglyceride accumulation, whereas the amino terminal domain is required for Cidea-mediated development of enlarged lipid droplets

  11. CIDEC is essential for the differentiation of adipose tissue

  12. These results suggest that CIDEA and CIDEC are novel genes regulated by insulin in human adipocytes and may play key roles in the effects of insulin, such as anti-apoptosis and lipid droplet formation.

  13. Methylation status of CIDEA, HAAO and RXFP3 had significant association with microsatellite instability in endometrial tumors.

  14. We propose an important and human-specific role for CIDEA in lipolysis regulation and metabolic complications of obesity.

  15. results support a role for cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) alleles in human obesity

  16. deglycosylation of CIDE-A correlated with enhanced nuclear export of the protein, and that high level of nonglycosylated CIDE-A inhibited TGFbeta1-dependent cell death.

  17. No dysregulation of CIDEA expression was observed in individuals with the metabolic syndrome

  18. The expression of the CIDE-A gene was regulated by CpG methylation of the promoter region.

  19. F allele of the CIDEA gene may serve as a risk factor for phenotypes related to metabolic syndrome in Japanese men.

  20. Cidea and other lipid droplet proteins define a novel, highly regulated pathway of triglyceride deposition in human WAT.

Mouse (Murine) Cell Death-Inducing DFFA-Like Effector A (CIDEA) Interaktionspartner

  1. our findings suggest that Cidea is highly associated with alcoholic fatty liver disease and Cidea expression is specifically induced by acetaldehyde, and this up-regulation is most likely mediated by SREBP1c.

  2. results suggest that FSP27beta negatively regulates CideA-promoted enlargement of lipid droplet size in brown adipocytes.

  3. The authors show demonstrate an essential role of an amphipathic helix in CIDEA, which facilitates embedding in the lipid droplet phospholipid monolayer and binds phosphatidic acid (PA).

  4. Data (including data from studies in knockout mice) suggest Cideb promotes lipid storage as droplets in hepatocytes under normal diet conditions; Cidea/Cidec promote fusion of lipid droplets leading to liver steatosis in fasting (16h) and obese mice.

  5. Cidea is highly associated with adiposity and insulin resistance, whereas Cidec is related to insulin sensitivity

  6. data reveal an important role of Cidea in controlling lipid droplet fusion, lipid storage in brown and white adipose tissue, and the development of obesity

  7. maternal diet modulates the age-associated changes in Cidea expression leading to the development of fatty liver

  8. Cidea is a crucial regulator of sebaceous gland lipid storage and sebum lipid secretion in mice.

  9. acts as transcriptional coactivator of C/EBPbeta in mammary glands to control lipid secretion

  10. Cidea is a critical regulator of free fatty acid-induced apoptosis as a novel downstream target for Foxo1 in pancreatic beta-cells

  11. These data indicate that the carboxy-terminal domain of Cidea directs lipid droplet targeting, lipid droplet clustering, and triglyceride accumulation, whereas the amino terminal domain is required for Cidea-mediated development of enlarged lipid droplets

  12. Cide-a and Cide-c are closely involved in the progression of hepatic steatosis, and that EPA inhibits Cide-a gene expression through SREBP-1 regulation.

  13. a role for Cidea in regulating energy balance and adiposity

  14. First protein known to directly modulate Ucp1 activity in regulation of thermogenesis and development of obesity and diabetes. Review.

  15. The mRNA for CIDEA was expressed in brown mouse adipocytes and was not influenced by obesity.

  16. Cidea is a novel target gene for both PPARalpha and -gamma in the liver where these two transcription factors utilize the same PPRE region for dual regulation

  17. CIDE-A levels are reduced in two different mouse models of obesity and this reduction may contribute to altered lipid metabolism.

  18. estrogen has large effects on gene expression in white adipose tissue and GPX3 and CIDEA could be important mediators of the effects of estrogen on fat mass

  19. These data strongly suggest that AMPK can be regulated by Cidea-mediated ubiquitin-dependent proteosome degradation, and provide a molecular explanation for the increased energy expenditure and lean phenotype in Cidea-null mice.

  20. Results describe the roles of RIP140 and PGC-1alpha in controlling the expression of CIDEA, an important regulatory factor in adipose cell function and obesity.

Cow (Bovine) Cell Death-Inducing DFFA-Like Effector A (CIDEA) Interaktionspartner

  1. These results suggest that CIDE-A and UCP1 are regulated by insulin and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism.

CIDEA Protein Überblick

Protein Überblick

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.

Genbezeichner und Symbole assoziert mit CIDEA

  • cell death-inducing DFFA-like effector a (CIDEA)
  • cell death-inducing DNA fragmentation factor, alpha subunit-like effector A (Cidea)
  • cell death-inducing DFFA-like effector a (Cidea)
  • cell death-inducing DFFA-like effector a (cidea)
  • cell death-inducing DFFA-like effector a L homeolog (cidea.L)
  • AW212747 Protein
  • cide-a Protein
  • CIDEA Protein
  • MGC89985 Protein

Bezeichner auf Proteinebene für CIDEA

cell death activator CIDE-A , cell death-inducing DFFA-like effector A , cell death-inducing DFFA-like effector a , cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

GENE ID SPEZIES
1149 Homo sapiens
12683 Mus musculus
468605 Pan troglodytes
490559 Canis lupus familiaris
527051 Bos taurus
768659 Gallus gallus
291541 Rattus norvegicus
703318 Macaca mulatta
493350 Xenopus (Silurana) tropicalis
495322 Xenopus laevis
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