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CABLES1 encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. Zusätzlich bieten wir Ihnen Cdk5 and Abl Enzyme Substrate 1 Antikörper (36) und Cdk5 and Abl Enzyme Substrate 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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cables1 is important for neural differentiation during embryogenesis, in a mechanism that likely involves interactions with the Cdk5/p35 kinase pathway.
We have identified four potentially pathogenic missense CABLES1 variants as a novel, although infrequent, cause of Cushing's Disease in children and young adults.
miR199a-3p and P53 are coupled through CABLES1 and comprise a novel negative feedback loop that likely contributes to cardiac c-kit(+) cell proliferation and apoptosis.
Cables1/p21 pathway has a strong effect on the induction of cell senescence and inhibition of cell growth, and acts as a novel regulatory mechanism in which p21 is probably one of several downstream effector molecules to mediate Cables1.
CABLES1 is a critical regulator of corticotrope proliferation that defines a pathway often inactivated in Cushing disease
the results suggest Cables1 as a novel p21 regulator through maintaining p21 stability and support the model that the tumor-suppressive function of Cables1 occurs at least in part through enhancing the tumor-suppressive activity of p21.
Results illuminated a dynamic regulatory system through which activated Akt and 14-3-3 work directly together to neutralize a potent tumor suppressor function of Cables1.
The results did not detect a significant association. It indicated that common genetic variations in CDK5 genes might not play a role in the genetic predisposition to autism.
Analysis of the RT-PCR prducts of the CABLES1 gene showed eight intragenic deletions in its mRNA transcripts; 5/8 are the result of RNA splicing.
Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation.
Mechanisms of CABLES1 gene inactivation in ovarian cancer development are reported.
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.
Cdk5 and Abl enzyme substrate 1
, CDK5 and ABL1 enzyme substrate 1
, CDK5 and ABL1 enzyme substrate 1-like
, interactor with CDK3 1
, cdk3-binding protein ik3-1
, interactor-1 with cdk3