Cdk5 and Abl Enzyme Substrate 1 Proteine (CABLES1)

CABLES1 encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. Zusätzlich bieten wir Ihnen Cdk5 and Abl Enzyme Substrate 1 Antikörper (37) und Cdk5 and Abl Enzyme Substrate 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CABLES1 91768 Q8TDN4
CABLES1 63955 Q9ESJ1
Ratte CABLES1 CABLES1 307585  
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Top Cdk5 and Abl Enzyme Substrate 1 Proteine auf antikoerper-online.de

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen 11 Days
$291.50
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CABLES1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartnern

Zebrafish Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartner

  1. cables1 is important for neural differentiation during embryogenesis, in a mechanism that likely involves interactions with the Cdk5/p35 kinase pathway.

Human Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartner

  1. We have identified four potentially pathogenic missense CABLES1 variants as a novel, although infrequent, cause of Cushing's Disease in children and young adults.

  2. miR199a-3p and P53 are coupled through CABLES1 and comprise a novel negative feedback loop that likely contributes to cardiac c-kit(+) cell proliferation and apoptosis.

  3. Cables1/p21 pathway has a strong effect on the induction of cell senescence and inhibition of cell growth, and acts as a novel regulatory mechanism in which p21 is probably one of several downstream effector molecules to mediate Cables1.

  4. CABLES1 is a critical regulator of corticotrope proliferation that defines a pathway often inactivated in Cushing disease

  5. the results suggest Cables1 as a novel p21 regulator through maintaining p21 stability and support the model that the tumor-suppressive function of Cables1 occurs at least in part through enhancing the tumor-suppressive activity of p21.

  6. Results illuminated a dynamic regulatory system through which activated Akt and 14-3-3 work directly together to neutralize a potent tumor suppressor function of Cables1.

  7. The results did not detect a significant association. It indicated that common genetic variations in CDK5 genes might not play a role in the genetic predisposition to autism.

  8. Analysis of the RT-PCR prducts of the CABLES1 gene showed eight intragenic deletions in its mRNA transcripts; 5/8 are the result of RNA splicing.

  9. Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation.

  10. Mechanisms of CABLES1 gene inactivation in ovarian cancer development are reported.

Mouse (Murine) Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartner

  1. Loss of Cables1 enhances tumor progression in the Apc(Min/+) mouse model and activates the Wnt/beta-catenin signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model.

  2. Agenesis of the corpus callosum frequency in Cables1(+/TAS) mice was significantly lower than that in Cables1(-/TAS) mice, indicating that wild-type Cables1 interfered with the dominant negative effect of Cables1(TAS).

  3. Data show that oocytes lacking Cables1 exhibit lower basal levels of TAp63alpha and reduced accumulation of phosphorylated TAp63alpha in response to genotoxic stress.

  4. Cables may be involved in the pathogenesis of ovarian carcinomas

  5. Loss or suppression of Cables may be an early step in the development of endometrial cancer.

  6. Cables is a relevant target of the chromosome 18q deletions frequently seen in human colorectal cancer.

  7. Cables1 null mice exhibit a significant expansion of oocyte numbers at the expense of oocyte quality throughout adulthood.

Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Protein Überblick

Protein Überblick

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit CABLES1

  • Cdk5 and Abl enzyme substrate 1 (CABLES1)
  • Cdk5 and Abl enzyme substrate 1 (cables1)
  • Cdk5 and Abl enzyme substrate 1 (CpipJ_CPIJ019832)
  • CDK5 and Abl enzyme substrate 1 (Cables1)
  • Cdk5 and Abl enzyme substrate 1 (Cables1)
  • CABL1 Protein
  • Cables Protein
  • CABLES1 Protein
  • HsT2563 Protein
  • ik3-1 Protein
  • si:dkey-2p18.3 Protein

Bezeichner auf Proteinebene für CABLES1

Cdk5 and Abl enzyme substrate 1 , CDK5 and ABL1 enzyme substrate 1 , CDK5 and ABL1 enzyme substrate 1-like , interactor with CDK3 1 , cdk3-binding protein ik3-1 , interactor-1 with cdk3

GENE ID SPEZIES
455335 Pan troglodytes
100059359 Equus caballus
100126070 Danio rerio
100345850 Oryctolagus cuniculus
100479459 Ailuropoda melanoleuca
6054063 Culex quinquefasciatus
100562423 Anolis carolinensis
100603520 Nomascus leucogenys
91768 Homo sapiens
63955 Mus musculus
768914 Gallus gallus
100682687 Canis lupus familiaris
100526114 Sus scrofa
100138286 Bos taurus
307585 Rattus norvegicus
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