Cdc2-Related Kinase, Arginine/serine-Rich Proteine (CRKRS)

human homolog may play a role in regulation of transcription and splicing [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen Cdc2-Related Kinase, Arginine/serine-Rich Antikörper (46) und Cdc2-Related Kinase, Arginine/serine-Rich Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CRKRS 51755 Q9NYV4
CRKRS 69131 Q14AX6
Ratte CRKRS CRKRS 192350 Q3MJK5
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Top Cdc2-Related Kinase, Arginine/serine-Rich Proteine auf

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Baculovirus infected Insect Cells Human GST tag   50 μg Anmelden zum Anzeigen 10 bis 12 Tage

CRKRS Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
Mouse (Murine)

Weitere Proteine zu Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) Interaktionspartner

  1. Cdk12 suppresses genes that support metabolic functions in stressed conditions. Cdk12 is not a generally essential Pol II kinase and is not required for the transcription of essential and housekeeping genes at least in adult tissues.

  2. CDK12 plays a role in controlling the epigenetic transition between euchromatin and heterochromatin, suggesting a chromatin regulatory mechanism in neuronal behaviors.

  3. The phosphorylation of the C-terminal domain of the RNA polymerase II by Cdk12 provides an elegant mechanism in regulating timed splicing of newly synthesized mRNA molecules.

Human Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) Interaktionspartner

  1. CDK12 regulates prereplicative complex assembly to promote mammalian cell proliferation.

  2. CDK12 gene amplification can contribute to the pathogenesis of breast cancer.

  3. BRCA1 downregulation combined with CHK1 inhibition induced excessive amounts of DNA damage, resulting in an inability to complete the S-phase. Therefore, we suggest CHK1 inhibition as a strategy for targeting BRCA1- or CDK12-deficient tumors.

  4. In Ovarian Cancer patients CDK12 loss is consistently associated with a particular genomic instability pattern characterized by hundreds of tandem duplications

  5. Structures of CDK12/CycK complexes solved in the presence of AMP-PNP.

  6. Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12)/cyclin K (CycK) complex, rendering the kinase inactive.

  7. CDK12 affects RNA processing events in two distinct ways: Indirectly through generating factor-binding phospho-epitopes on the CTD of elongating RNAPII and directly through binding to specific factors

  8. CDK12 and CDK13 losses in HCT116 cells preferentially affect expression of DNA damage response.

  9. CDK12 plays an important role in cotranscriptional processing of c-FOS transcripts

  10. CDK12 has properties that should confirm interest in its use as a biomarker.

  11. many CDK12 mutations are an unrecognized cause of HR defects in ovarian cancers

  12. CDK12 interacts with cyclin K and is required to maintain embryonnic stem cell self-renewal.

  13. Cyclin K1 is the primary cyclin partner for CDK12/CrkRS and it is required for activation of CDK12/CrkRS to phosphorylate the C-terminal domain of RNA Pol II.

  14. through regulation of expression of DNA damage response genes, CycK/Cdk12 protects cells from genomic instability

  15. Data show that siRNA knockdown of hCDK12 in HeLa cells results in alterations in the CTD phosphorylation state.

  16. CRK7 modifies MAP kinases regulation and resistance to estrogen signaling inhibitors in breast cancers.

Mouse (Murine) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) Interaktionspartner

  1. Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos.

  2. Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways

  3. The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) Protein Überblick

Protein Überblick

human homolog may play a role in regulation of transcription and splicing

Genbezeichner und Symbole assoziert mit CRKRS

  • Cyclin-dependent kinase 12 (Cdk12)
  • cyclin dependent kinase 12 (CDK12)
  • cyclin-dependent kinase 12 (Cdk12)
  • 1810022J16Rik Protein
  • AC017581 Protein
  • AI646528 Protein
  • anon-WO0140519.165 Protein
  • cg7597 Protein
  • Crk7 Protein
  • CRKR Protein
  • Crkrs Protein
  • D11Ertd752e Protein
  • dCDK12 Protein
  • Dmel\\CG7597 Protein
  • gi24668141 Protein
  • hCDK12 Protein
  • Pksc Protein

Bezeichner auf Proteinebene für CRKRS

CG7597-PA , CG7597-PB , CG7597-PC , Cdk12-PA , Cdk12-PB , Cdk12-PC , Cdc2-related kinase, arginine/serine-rich , CDC2-related protein kinase 7 , cell division cycle 2-related protein kinase 7 , cell division protein kinase 12 , CDC2-related kinase 7 , CDC2-related kinase, arginine/serine-rich , protein kinase for splicing component , cyclin-dependent kinase 12 isoform , cyclin-dependent kinase 12 , Cell division protein kinase 12

40385 Drosophila melanogaster
100354313 Oryctolagus cuniculus
51755 Homo sapiens
69131 Mus musculus
192350 Rattus norvegicus
511513 Bos taurus
100467815 Ailuropoda melanoleuca
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