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human homolog may play a role in regulation of transcription and splicing [RGD, Feb 2006]..
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Cdk12 suppresses genes that support metabolic functions in stressed conditions. Cdk12 is not a generally essential Pol II kinase and is not required for the transcription of essential and housekeeping genes at least in adult tissues.
CDK12 plays a role in controlling the epigenetic transition between euchromatin and heterochromatin, suggesting a chromatin regulatory mechanism in neuronal behaviors.
The phosphorylation of the C-terminal domain of the RNA polymerase II by Cdk12 provides an elegant mechanism in regulating timed splicing of newly synthesized mRNA molecules.
CDK12 gene amplification can contribute to the pathogenesis of breast cancer.
BRCA1 downregulation combined with CHK1 (zeige CHEK1 Proteine) inhibition induced excessive amounts of DNA damage, resulting in an inability to complete the S-phase. Therefore, we suggest CHK1 (zeige CHEK1 Proteine) inhibition as a strategy for targeting BRCA1- or CDK12-deficient tumors.
In Ovarian Cancer patients CDK12 loss is consistently associated with a particular genomic instability pattern characterized by hundreds of tandem duplications
Structures of CDK12/CycK (zeige CCNK Proteine) complexes solved in the presence of AMP (zeige APRT Proteine)-PNP (zeige NP Proteine).
Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12)/cyclin K (CycK (zeige CCNK Proteine)) complex, rendering the kinase inactive.
CDK12 affects RNA processing events in two distinct ways: Indirectly through generating factor-binding phospho-epitopes on the CTD of elongating RNAPII and directly through binding to specific factors
CDK12 and CDK13 (zeige CDK13 Proteine) losses in HCT116 cells preferentially affect expression of DNA damage response.
CDK12 plays an important role in cotranscriptional processing of c-FOS transcripts
CDK12 has properties that should confirm interest in its use as a biomarker.
many CDK12 mutations are an unrecognized cause of HR defects in ovarian cancers
Spontaneous DNA damage was revealed by an increase in 53BP1 (zeige TP53BP1 Proteine) foci among cells cultured from Cdk12(-/-) embryos.
Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways
The findings of this study suggest that Cdk12 and Cdk13 (zeige CDK13 Proteine) regulate axonal elongation through a common signaling pathway that modulates Cdk5 (zeige CDK5 Proteine) expression.
human homolog may play a role in regulation of transcription and splicing
, Cdc2-related kinase, arginine/serine-rich
, CDC2-related protein kinase 7
, cell division cycle 2-related protein kinase 7
, cell division protein kinase 12
, CDC2-related kinase 7
, CDC2-related kinase, arginine/serine-rich
, protein kinase for splicing component
, cyclin-dependent kinase 12 isoform
, cyclin-dependent kinase 12
, Cell division protein kinase 12