Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) ELISA Kits

CBLB encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase.

list all ELISA KIts Gen GeneID UniProt
Anti-Human CBLB CBLB 326625 Q96EY8
Anti-Maus CBLB CBLB 208650 Q3TTA7
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Top Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA Kits auf antikoerper-online.de

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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 25 pg/mL 78-5000 pg/mL   96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
  96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Weitere ELISA Kits für Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Interaktionspartner

Human Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Interaktionspartner

  1. analysis of how molecular chaperones interact with ATR in methylmalonic aciduria cblB type

  2. MMAB (zeige MMAB ELISA Kits) might be a target and potential biomarker of hepatotoxicity in EFV-induced liver toxicity

  3. These findings suggest that rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB may contribute to the susceptibility of coronary heart disease by altering plasma HDL-C levels in Han Chinese.

  4. MMAB mutations, including one novel nonsense mutation (c.12 C>A [p.C4X]), were identified in all members of the cblB cohort.

  5. Pathogenicity of the human truncation mutant results from its inability to sequester AdoCbl for direct transfer to methylmalonyl-CoA mutase (zeige MUT ELISA Kits), resulting in holoenzyme formation.

  6. c.584G>A, c.349-1G>C, and c.290G>A mutations affect the splicing process of ATR.

  7. These data suggest MMAB (zeige MMAB ELISA Kits) is the most likely gene influencing high-density lipoprotein-cholesterol levels at MMAB (zeige MMAB ELISA Kits)-MVK (zeige MVK ELISA Kits) locus.

  8. Characterization of ligand-binding by MMAB (zeige MMAB ELISA Kits) provides insight into the mechanism of cobalamin adenosylation and the effect of patient mutations in the inherited disorder

  9. report the identification of ATR cDNA as well as the corresponding gene; ATR expression is altered in cell lines derived from cblB methylmalonyl aciduria patients; propose that inborn errors in the ATR gene identified here result in methylmalonyl aciduria

  10. Results describe two common polymorphic variants of ATP:cob(I)alamin adenosyltransferase (zeige MMAB ELISA Kits) that are found in normal individuals, and their interactions with methionine synthase reductase (zeige MTRR ELISA Kits).

Mouse (Murine) Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Interaktionspartner

  1. The establishment of a new model of concurrent tissue-selective CBL/CBL (zeige CBL ELISA Kits)-B deletion should allow a clear assessment of the tumor-intrinsic roles of CBL/CBL (zeige CBL ELISA Kits)-B in non-myeloid malignancies and help test the potential for CBL/CBL (zeige CBL ELISA Kits)-B inactivation in immunotherapy of tumors.

  2. GSK3 catalyzes two previously unreported phosphorylation events at Ser(476) and Ser(480) of Cbl-b. Constitutive activation of PKB in vivo results in a loss of tolerance that is mediated through the downregulation of Cbl-b. The PI3K-PKB-GSK-3 pathway is a novel regulatory axis that is important for controlling the decision between T cell activation and tolerance via Cbl-b.

  3. These studies reveal a novel, cell-autonomous requirement of CBL (zeige CBL ELISA Kits) and CBL-B in epithelial stem cell maintenance during organ development and remodeling through modulation of mTOR (zeige FRAP1 ELISA Kits) signaling.

  4. CBLB directs polyubiquitination of dectin-1 (zeige CLEC7A ELISA Kits) and dectin-2 (zeige CLEC6A ELISA Kits), two key pattern-recognition receptors for sensing Candida albicans, and their downstream kinase SYK (zeige SYK ELISA Kits), thus inhibiting dectin-1 (zeige CLEC7A ELISA Kits)- and dectin-2 (zeige CLEC6A ELISA Kits)-mediated innate immune responses.

  5. CBLB controls proximal C-type lectin receptor signaling in macrophages and dendritic cells. CBLB associates with SYK and ubiquitinates SYK, dectin-1, and dectin-2 after fungal recognition. CBLB deficiency results in increased inflammasome activation, enhanced reactive oxygen species production, and increased fungal killing.

  6. study indicates that Cbl-b negatively regulates CLR-mediated antifungal innate immunity

  7. Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl (zeige CBL ELISA Kits)-b deficiency-driven murine model of myeloproliferative disorders.

  8. Mechanistically, NFATc1 (zeige NFATC1 ELISA Kits) induces Nur77 (zeige NR4A1 ELISA Kits) expression at late stage of osteoclast differentiation; in turn, Nur77 (zeige NR4A1 ELISA Kits) transcriptionally up-regulates E3 ubiquitin ligase Cbl-b, which triggers NFATc1 (zeige NFATC1 ELISA Kits) protein degradation.

  9. Silencing Cbl-b significantly enhanced T lymphocyte function and T lymphocyte cytotoxicity activity

  10. mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found.

Genbezeichner und Symbole assoziert mit CBLB

  • methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB) Antikörper
  • Casitas B-lineage lymphoma b (Cblb) Antikörper
  • AI429560 Antikörper
  • AI851073 Antikörper
  • ATR Antikörper
  • Cbl-b Antikörper
  • cblB Antikörper
  • cob Antikörper

Bezeichner auf Proteinebene für CBLB

ATP:cob(I)alamin adenosyltransferase , ATP:corrinoid adenosyltransferase , aquocob(I)alamin vitamin B12s adenosyltransferase , cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial , methylmalonic aciduria type B protein , Casitas B-lineage lymphoma proto-oncogene b , E3 ubiquitin-protein ligase CBL-B , RING-type E3 ubiquitin transferase CBL-B , SH3-binding protein CBL-B , Signal transduction protein CBL-B , casitas B-lineage lymphoma proto-oncogene b , signal transduction protein CBL-B

326625 Homo sapiens
208650 Mus musculus
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