anti-Caspase Recruitment Domain Family, Member 14 (CARD14) Antikörper

CARD14 encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Zusätzlich bieten wir Ihnen CARD14 Proteine (6) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CARD14 79092 Q9BXL6
CARD14 170720 Q99KF0
CARD14 688292  
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Showing 10 out of 59 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IC, IF, IHC, WB Immunofluorescent analysis of CARD14 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of CARD14 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-CARD14 / CARMA2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Maus Unkonjugiert WB Western Blot analysis of CARD14 expression in transfected 293T cell line by CARD14 MaxPab polyclonal antibody.<br><br>Lane 1: CARD14 transfected lysate(47.74 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Maus Unkonjugiert ELISA Detection limit for recombinant GST tagged CARD14 is approximately 0.1ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC Immunohistochemistry analysis of CARD14 in human placenta tissue with CARD14 polyclonal antibody  at 5 ug/mL. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$355.73
Details
Human Kaninchen Unkonjugiert EIA, IHC (p)   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$474.10
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC   100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, IHC (p)   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$757.17
Details
Human Huhn Unkonjugiert WB 0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Maus Unkonjugiert ELISA Detection limit for recombinant GST tagged CARD14 is approximately 0.1ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details

Am meisten referenzierte anti-CARD14 Antikörper

  1. Human Polyclonal CARD14 Primary Antibody für WB - ABIN528893 : Huh, Kim, Kim, Song, Jung, Jeong, Lee, Kim, Lee, An: Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer. in British journal of cancer 2013 (PubMed)

Weitere Antikörper gegen CARD14 Interaktionspartner

Human Caspase Recruitment Domain Family, Member 14 (CARD14) Interaktionspartner

  1. Results identified RNF7 (zeige RNF7 Antikörper) to interact with CARMA2 regulating its NF-kappaB (zeige NFKB1 Antikörper)-activating capacity. Mechanistically, RNF7 (zeige RNF7 Antikörper) influences CARMA2 signaling by regulating the ubiquitination state of MALT1 (zeige MALT1 Antikörper) and the NF-kappaB (zeige NFKB1 Antikörper)-regulatory molecule NEMO (zeige IKBKG Antikörper). Interestingly, CARMA2short (CARMA2sh) mutants associated with psoriasis susceptibility escape the negative control exerted by RNF7 (zeige RNF7 Antikörper).

  2. The serine/threonine kinase (zeige TLK2 Antikörper) ULK2 (zeige ULK2 Antikörper) binds to and phosphorylates CARMA2sh.

  3. MALT1 (zeige MALT1 Antikörper) deficiency or pharmacological inhibition of MALT1 (zeige MALT1 Antikörper) catalytic activity inhibits pathogenic mutant CARD14-induced cytokine and chemokine (zeige CCL1 Antikörper) expression in human primary keratinocytes.

  4. CARD14/MALT1 (zeige MALT1 Antikörper)-mediated signaling in keratinocytes has a role in psoriasis [review]

  5. The results indicate that the common CARD14 p.Arg820Trp variant might have a significant effect on the response to anti-TNF (zeige TNF Antikörper) therapies among patients with psoriasis. In addition, rare CARD14 missense variants could also predispose to a better response.

  6. Our findings, combined with the published literature, suggest that Pityriasis Rubra Pilaris Type V, both familial and sporadic, can be caused by CARD14 mutations.

  7. Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10 (zeige BCL10 Antikörper)-MALT1 (zeige MALT1 Antikörper)-dependent NF-kappaB (zeige NFKB1 Antikörper) activation

  8. genetic evidence suggests association of the CARD14 single nucleotide polymorphism rs11652075 and other rare mutations in this gene with psoriasis. To assess whether combined data support the relationship between CARD14 rs11652075 and susceptibility to this disease, we conducted a meta-analysis. Our results demonstrate a significant association between the CARD14 rs11652075 polymorphism and psoriasis.

  9. The authors observations provide further insights into the genetics of psoriasis and functional information on novel CARD14 mutational variants seen in cases from Tunisia and other populations.

  10. Genetic interactions of SNPs in CARD14, SENP1 (zeige SENP1 Antikörper) and VEGFA (zeige VEGFA Antikörper) might represent a functional mechanism in the pathogenesis of high altitude polycythemia.

Mouse (Murine) Caspase Recruitment Domain Family, Member 14 (CARD14) Interaktionspartner

  1. in experimental models of psoriasis induced by either imiquimod cream or recombinant IL-23 (zeige IL23A Antikörper) injection, the psoriasiform skin inflammation was abrogated in Card14(-/-) mice

CARD14 Antigen-Profil

Protein Überblick

This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit CARD14

  • caspase recruitment domain family member 14 (CARD14) Antikörper
  • caspase recruitment domain family, member 14 (Card14) Antikörper
  • caspase recruitment domain family member 14 (Card14) Antikörper
  • Bimp2 Antikörper
  • CARMA2 Antikörper
  • PRP Antikörper
  • PSORS2 Antikörper
  • PSS1 Antikörper

Bezeichner auf Proteinebene für CARD14

CARD-containing MAGUK protein 2 , bcl10-interacting maguk protein 2 , card-maguk protein 2 , carma 2 , caspase recruitment domain-containing protein 14 , bcl10-interacting MAGUK protein 2

GENE ID SPEZIES
79092 Homo sapiens
170720 Mus musculus
688292 Rattus norvegicus
100733298 Cavia porcellus
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