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Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. Zusätzlich bieten wir Ihnen Casein Kinase 2, alpha 1 Polypeptide Proteine (21) und Casein Kinase 2, alpha 1 Polypeptide Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CSNK2A1 Primary Antibody für WB - ABIN1944742
Devilat, Carvallo: Structure and sequence of an intronless gene for human casein kinase II-alpha subunit. in FEBS letters 1993
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Human Polyclonal CSNK2A1 Primary Antibody für WB - ABIN1881717
Ahmed, Davis, Hanten, Lambert, McIvor, Goueli: Cloning of cDNAs encoding the alpha and beta subunits of rat casein kinase 2 (CK-2): investigation of molecular regulation of CK-2 by androgens in rat ventral prostate. in Cellular & molecular biology research 1994
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Human Polyclonal CSNK2A1 Primary Antibody für WB - ABIN1944758
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
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Human Monoclonal CSNK2A1 Primary Antibody für IF, PLA - ABIN514706
Lin, Hung, Lin, Li, Lee, Li, Chen, Chen, Yang: CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation. in Cancer biotherapy & radiopharmaceuticals 2011
Vascular smooth muscle protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
we have identified kinases, particularly CK2, associated with the autocrine malignant cell network that may play a central role in sustaining the cytokine network and/or mediating its effects in ovarian cancer.
CK2 and AKT (zeige AKT1 Antikörper) display a high degree of cross-regulation of their respective functions, both directly, through physical interaction and phosphorylation, and indirectly, through an intense cross-talk of key downstream effectors, ultimately leading to sustained AKT (zeige AKT1 Antikörper) activation. (Review)
Phosphorylation of Ikaros (zeige IKZF1 Antikörper) by CK2 impairs Ikaros (zeige IKZF1 Antikörper) DNA-binding ability, as well as Ikaros (zeige IKZF1 Antikörper) ability to regulate gene expression and function as a tumor suppressor in leukemia. (Review)
data implicate CK2 as a regulator of the Th17/Treg axis and Th17 cell maturation and suggest that CK2 could be targeted for the treatment of Th17 cell-driven autoimmune disorders.
This study demonstrates that CSNK2A1 and SIRT6 (zeige SIRT6 Antikörper) are indicators of poor prognosis for breast carcinomas and that CSNK2A1-mediated phosphorylation of SIRT6 (zeige SIRT6 Antikörper) might be involved in the progression of breast carcinoma.
Our results disclose a novel interplay between ubiquitin- and phosphorylation-dependent signalling, and represent the first report of a regulatory mechanism for UIM-dependent function. They also suggest that CK2 inhibitors could release the full neuroprotective potential of HSJ1 (zeige DNAJB2 Antikörper), and deserve future interest as therapeutic strategies for neurodegenerative disease.
CK2 inhibition in monocyte-derived dendritic cells led to an enhanced Th2 polarization in the absence of contact sensitizer stimulation.
In the present work we have shown a key role for protein kinase CK2 in promoting LSC (zeige ARHGEF1 Antikörper) survival through the modulation of the STAT3 (zeige STAT3 Antikörper), NF-kappaB (zeige NFKB1 Antikörper) and AKT (zeige AKT1 Antikörper)/FOXO (zeige FOXO3 Antikörper) signaling pathways. We have also shown that CK2 inactivation makes LSCs more sensitive to the chemotherapeutic drug doxorubicin.
our findings establish an important regulatory role of CK2alpha on BMI1 (zeige BMI1 Antikörper) phosphorylation and stability and implicate the CK2alpha/BMI1 (zeige BMI1 Antikörper) axis in ovarian cancer.
To clarify the control mechanism of the catalytic activity of casein kinase 2 (CK2) during early embryonic development in the silkworm, Bombyx mori, attempted an in-vitro functional analysis by using the recombinant alpha and beta subunits of B. mori CK2
identify the the ZmeIF5A serine residues phosphorylated by CK2
analysis of free energy differences of binding of adenosine triphosphate (ATP) and guanine triphosphate (GTP (zeige AK3 Antikörper)) to the protein kinase CK2
The regulatory subunit of protein kinase CK2 is identified as a novel intracellular partner of AdipoR1 and CK2 is shown to be an effector molecule in adiponectin signaling.
CK2alpha-4 is a splicing variant of maize protein kinase CK2, and may function as a negative regulator of other CK2s.
Data (including data from studies using knockout mice) suggest that Brg1 (zeige SMARCA4 Antikörper) is phosphorylated by casein kinase 2 (Ck2; Ck2alpha1 and Ck2alpha-prime are catalytic subunits) in proliferating skeletal myoblasts; Brg1 (zeige SMARCA4 Antikörper) is catalytic subunit of SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) chromatin-remodeling enzymes; Ck2-mediated phosphorylation of Brg1 (zeige SMARCA4 Antikörper) appears to regulate myoblast proliferation. (Brg1 (zeige SMARCA4 Antikörper) = Brahma (zeige SMARCA2 Antikörper)-related gene 1 protein)
Casein kinase 2 plays a central role in striatal physiology and in severity of l-DOPA-induced dyskinesia.
Casein kinase 1 (zeige CSNK1A1 Antikörper) (alpha, delta and epsilon) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression.
These data support a model in which activated Akt (zeige AKT1 Antikörper) enhances rRNA synthesis both by preventing TIF-IA (zeige RRN3 Antikörper) degradation and phosphorylating CK2alpha, which in turn phosphorylates TIF-IA (zeige RRN3 Antikörper).
receptor beta and its domains interact with casein kinase 2, phosphokinase C, and N-myristoylation sites of mitochondrial and nuclear proteins in mouse brain
TNP1 is a newly identified binding partner of the alpha-subunit of casein kinase 2.
Casein kinase II has a role in phosphorylation of NF-kappaB (zeige NFKB1 Antikörper) p65 (zeige NFkBP65 Antikörper) subunit enhancement of inducible nitric-oxide synthase (zeige NOS2 Antikörper) gene transcription
CK2 selectively phosphorylates MKP3 (zeige DUSP6 Antikörper), suggesting cross-regulation between CK2alpha and MKP3 (zeige DUSP6 Antikörper), as well as a modulation of ERK2-MAPK (zeige MAPK1 Antikörper) signaling by CK2alpha via MKP3 (zeige DUSP6 Antikörper)
In cultured hippocampal neurons, the capacity of Nerve Growth Factor to promote axon elongation is mostly mediated by p75NTR (zeige NGFR Antikörper), and the activation of this pathway leads to the inactivation of GSK-3beta (zeige GSK3b Antikörper).
CK2 involvement in the phenomenon of the drug resistance was investigated.
Involvement of ubiquitous protein kinase CK2 in angiogenesis. Naturally derived CK2 inhibitors may be useful for treatment of proliferative retinopathies. (Protein kinase CK2)
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
CK II alpha 3
, CK2 catalytic subunit alpha
, casein kinase II alpha 1 polypeptide pseudogene
, casein kinase II alpha 1 subunit
, casein kinase II subunit alpha
, protein kinase CK2
, casein kinase 2 alpha subunit
, ck2 alpha
, casein kinase 2, alpha 1 polypeptide
, casein kinase 2 protein catalytic subunit
, casein kinase II subunit alpha-like
, CK II alpha
, casein kinase 2, alpha subunit
, CK II
, casein kinase II alpha subunit
, CK2 alpha subunit
, casein kinase2 subunit alpha
, casein protein kinase subunit alpha
, Casein kinase II alpha subunit
, casein kinase II, alpha 1 polypeptide
, casein kinase II, alpha 1 related sequence 4
, Casein kinase II subunit alpha'
, alpha subunit of casein kinase II