Calsyntenin 1 (CLSTN1) ELISA Kits

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus CLSTN1 CLSTN1 65945 Q9EPL2
Anti-Human CLSTN1 CLSTN1 22883 O94985
Anti-Ratte CLSTN1 CLSTN1 313717 Q6Q0N0
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Weitere ELISA Kits für Calsyntenin 1 Interaktionspartner

Zebrafish Calsyntenin 1 (CLSTN1) Interaktionspartner

  1. Our results suggest a model in which Clstn-1 patterns separate axonal compartments and define their ability to branch by directing trafficking of specific endosomes.

Mouse (Murine) Calsyntenin 1 (CLSTN1) Interaktionspartner

  1. These results indicate that regulated intramembrane proteolysis of Alca by gamma-secretase regulates APP (zeige APP ELISA Kits) trafficking and the production of Abeta (zeige APP ELISA Kits) in vivo.

  2. these results highlight a key role for calsyntenin-1 in the transport of NMDA receptors to synaptic targets, which is necessary for the maturation of neuronal circuits during early development.

  3. Alcalpha is efficiently processed in part to minimize the inappropriate peripheral retention of kinesin-1

  4. Immunoisolated calsyntenin-1 organelles from murine brain homogenates; determined their proteome by MS. Found calsyntenin-1 organelles are endowed with components of the endosomal trafficking machinery and contained the beta-amyloid precursor protein (APP).

  5. Phosphorylation of KLC1 (zeige KLC1 ELISA Kits) at serine 460 modulates binding and trafficking of calsyntenin-1.

  6. Calsyntenin-1 links a certain type of vesicular and tubulovesicular organelles to the Kinesin-1 motor.

  7. The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.

Human Calsyntenin 1 (CLSTN1) Interaktionspartner

  1. Results suggests that APP (zeige APP ELISA Kits) partially compensates for defective Alcalpha in anterograde transport by providing an alternative cargo receptor for kinesin-1.

  2. Calsyntenin-1 contributes to the early stages of the hepatitis C virus replication cycle and the formation of the replication complex.

  3. Increased plasma p3-Alcalpha35, a major fragment of alcalpha1, may indicate an endophenotype in Alzheimer's disease patients with progressive cognitive impairment.

  4. Increased plasma p3-alcadein (alc) alpha, evident in the early stages of cognitive impairment, suggests that alc metabolites are useful plasma biomarkers of Alzheimer's disease.

  5. findings show that calsyntenin-1 is reduced in Alzheimer's disease brains and that the extent of this reduction correlates with increased amyloid-beta

  6. CLSTN1 is a target gene of the BACH1 (zeige BACH1 ELISA Kits) transcription factor according to ChIP-seq analysis in HEK (zeige EPHA3 ELISA Kits) 293 cells.

  7. Phosphorylation of KLC1 (zeige KLC1 ELISA Kits) at serine 460 modulates binding and trafficking of calsyntenin-1.

  8. Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation [alcalpha1, alcbeta, alcgamma (zeige CLSTN2 ELISA Kits)]

Calsyntenin 1 (CLSTN1) Antigen-Profil

Beschreibung des Gens

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity).

Genbezeichner und Symbole assoziert mit Calsyntenin 1 (CLSTN1) ELISA Kits

  • calsyntenin 1 (CLSTN1) Antikörper
  • calsyntenin 1 (clstn1) Antikörper
  • calsyntenin 3 (clstn3) Antikörper
  • beta-catenin-interacting protein 1 (LOC100356725) Antikörper
  • calsyntenin-1 (LOC100435584) Antikörper
  • calsyntenin 1 (Clstn1) Antikörper
  • beta-catenin-interacting protein 1 (LOC479600) Antikörper
  • 1810034E21Rik Antikörper
  • ALC-ALPHA Antikörper
  • alcalpha1 Antikörper
  • alcalpha2 Antikörper
  • CALSYNTENIN-1 Antikörper
  • CDHR12 Antikörper
  • clstn1 Antikörper
  • Cst-1 Antikörper
  • CSTN1 Antikörper
  • fm67g03 Antikörper
  • PIK3CD Antikörper
  • wu:fk52g02 Antikörper
  • wu:fm67g03 Antikörper
  • XB31alpha Antikörper
  • zgc:56528 Antikörper
  • zgc:153744 Antikörper

Bezeichner auf Proteinebene für Calsyntenin 1 (CLSTN1) ELISA Kits

calsyntenin-1 , calsyntenin 1 , calsyntenin 3 , calsyntenin-1-like , alc-alpha , alcadein alpha , alcadein-alpha , alcadein alpha 1 , alzheimer-related cadherin-like protein , cadherin-related family member 12 , non-classical cadherin XB31alpha , non-classical cadherin XB31alpha1

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100145668 Xenopus (Silurana) tropicalis
100356725 Oryctolagus cuniculus
100435584 Pongo abelii
100611252 Pan troglodytes
65945 Mus musculus
22883 Homo sapiens
313717 Rattus norvegicus
479600 Canis lupus familiaris
100520617 Sus scrofa
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