Calpain 2 Proteine (CAPN2)

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (By similarity).. Zusätzlich bieten wir Ihnen Calpain 2 Antikörper (74) und Calpain 2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Maus CAPN2 CAPN2 12334 O08529
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Top Calpain 2 Proteine auf

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Hefe Plasmodium vivax His tag   1 mg 60 bis 71 Tage
Hefe Trypanosoma brucei His tag   1 mg 60 bis 71 Tage
Rind (Kuh) Unkonjugiert   10 μg 6 Days

CAPN2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat

Am meisten referenzierte Calpain 2 Proteine

  1. Human Calpain 2 Protein expressed in HEK-293 Cells - ABIN2713061 : Briz, Hsu, Li, Lee, Bi, Baudry: Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)
    Show all 9 Pubmed References

Weitere Proteine zu Calpain 2 (CAPN2) Interaktionspartnern

Mouse (Murine) Calpain 2 (CAPN2) Interaktionspartner

  1. Our data indicate that calpain-1 activity is neuroprotective and calpain-2 activity is neurodegenerative after traumatic Brain Injury

  2. Following TBI, calpain-2 activation cleaved PTPN13, activated c-Abl and triggered tau tyrosine phosphorylation.

  3. our findings provide evidence that increased spinal cord CALP2 and microglia cell activation may have early causative roles in IL-6 over-expression following motor nerve injury

  4. calpain contributes to the regulation of new gene expression that is necessary for these memory processes as a regulator of Ca(2+)-signal transduction pathway.

  5. calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2/TGF-beta1 pathway.

  6. indicate that calpain-1 and calpain-2 play opposite roles in high increased intraocular pressure-induced ischemic injury

  7. Results indicate that calpain-1 and calpain-2 are differentially activated in hippocampus following seizure activity, with calpain-1 activation being limited to a small population of interneurons, and possibly triggering neuroprotective events, while calpain-2 is widely activated in pyramidal neurons of CA1 and CA3, and triggers neurodegenerative cascades.

  8. these findings identify ASAP2 as a new target of Selk-dependent palmitoylation and reveal a new mechanism regulating the efficiency of FcgammaR-mediated phagocytosis.

  9. ENaC activity is regulated by calpain-2 proteolysis of MARCKS.

  10. calpains and calpastatin in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22-5HTT(+) strain) PH, were investigated.

  11. Leukocyte calpain-1/calpain-2 deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal Aortic aneurysms in mice.

  12. These results suggest that TRPV1/Ca(2+)/calpain 2-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.

  13. Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension.

  14. LOX-1 is, at least in part, responsible for the inhibitory effect of ox-LDL on macrophage migration and this process involves calpain-1 and -2.

  15. Dicer is predominantly a Capn2 substrate. Dicer levels were altered in platelets from diabetic mice due to the cleavage of the enzyme by calpain, resulting in loss of function.

  16. Data suggest that vitamin D3 up-regulates skeletal muscle fat deposition, up-regulates muscle m-calpain/Capn2 and u-calpain/Capn1 expression, and down-regulates muscle calpastatin expression.

  17. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice.

  18. Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 and TMOD4 leads to thin filament elongation in dystrophic skeletal muscle.

  19. extrasynaptic NMDAR-coupled m-calpain activation is neurodegenerative

  20. Down-regulated expression of calpain-2 or talin-1, or pharmacological interference with calpain action, did not affect toxin binding but reduced endocytosis and increased the survival of cells exposed to anthrax lethal toxin.

Calpain 2 (CAPN2) Protein Überblick

Protein Überblick

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (By similarity).

Genbezeichner und Symbole assoziert mit Calpain 2 Proteine (CAPN2)

  • calpain 2 (Capn2)
  • calpain 2, gene2 (capn2.2)
  • calpain 2 (CAPN2)
  • calpain 2, (m/II) large subunit b (capn2b)
  • AI326419 Protein
  • Capa-2 Protein
  • Capa2 Protein
  • CAPN2 Protein
  • im:6908877 Protein
  • m-calpain Protein
  • m-calpin Protein
  • zgc:109906 Protein

Bezeichner auf Proteinebene für Calpain 2 Proteine (CAPN2)

80 kDa M-calpain subunit , CALP80 , CANP 2 , calcium-activated neutral proteinase 2 , calpain M-type , calpain-2 catalytic subunit , calpain-2 large subunit , cysteine proteinase , m-calpain 80 kDa large subunit , m-calpain large subunit , millimolar-calpain , calpain 2 , calpain 2, (m/II) large subunit b

12334 Mus musculus
448035 Xenopus (Silurana) tropicalis
100127211 Ovis aries
563053 Danio rerio
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