Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit Proteine (CACNA1I)

CACNA1I encodes the pore-forming alpha subunit of a voltage gated calcium channel. Zusätzlich bieten wir Ihnen CACNA1I Antikörper (21) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Maus CACNA1I CACNA1I 239556  
CACNA1I 8911 Q9P0X4
Ratte CACNA1I CACNA1I 56827 Q9Z0Y8
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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CACNA1I Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,

Weitere Proteine zu Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) Interaktionspartnern

Mouse (Murine) Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) Interaktionspartner

  1. Membrane-protein extraction and use of an intracellular protein (zeige CKAP2 Proteine)-transport inhibitor showed that GDF-15 (zeige GDF15 Proteine) promoted CaV3.1 (zeige CACNA1G Proteine) and CaV3.3 alpha-subunit (zeige POLG Proteine) expression by trafficking to the membrane.

  2. Extracellular pressure increases [Ca(2 (zeige CA2 Proteine)+)]i via Cav3.3, driving a PKC-beta (zeige PRKCB Proteine)- IKK (zeige CHUK Proteine)- IkB (zeige NFKBIB Proteine)-NF-kB pathway that stimulates cancer cell proliferation

  3. using Ca(V)3.3(-/-) mice we found that Ca(V)3.3 channels trigger synaptic plasticity in reticular thalamic neurons

  4. data identify a central role for Ca(V)3.3 channels in the rhythmogenic properties of the sleep-spindle generator and provide a molecular target to elucidate the roles of sleep spindles for brain function and development.

Human Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I) Interaktionspartner

  1. analyses suggest that a single copy of Chr22: 39665939G > A CACNA1I has the capacity to disrupt CaV3.3 channel-dependent functions, including rebound bursting in TRN (zeige TNPO1 Proteine) neurons, with potential implications for schizophrenia pathophysiology.

  2. low-voltage activation characteristics of CaV3.3 channels

  3. CACNA1I is a risk gene for schizophrenia in the Han Chinese population

  4. human Cav3.1, Cav3.2, and Cav3.3 T-type channels specifically associate with CaM at helix 2 of the gating brake in the I-II linker of the channels.

  5. significant association exists between the CACNA1I gene and schizophrenia in the Uighur Chinese population

  6. CACNA1I variant is associated with differential antiepileptic drug response in childhood absence epilepsy.

  7. CaV3.1 (zeige CACNA1G Proteine), CaV3.2 (zeige CACNA1H Proteine) and CaV3.3 channels, are best recognized for their negative voltage of activation and inactivation thresholds that allow them to operate near the resting membrane potential of neurons.

  8. Extracellular pressure increases [Ca(2 (zeige CA2 Proteine)+)]i via Cav3.3, driving a PKC-beta (zeige PRKCB Proteine)- IKK (zeige CHUK Proteine)- IkB (zeige NFKBIB Proteine)-NF-kB pathway that stimulates cancer cell proliferation

  9. Ethanol primarily affects the CaV3.2 isoform of T-type Ca(2)+ channels, acting through protein kinase C.

  10. Specific contribution of human T-type calcium channel isotypes (alpha(1G (zeige CACNA1G Proteine)), alpha(1H) and alpha(1I)) to neuronal excitability.

CACNA1I Protein Überblick

Protein Überblick

This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit CACNA1I

  • calcium voltage-gated channel subunit alpha1 I (CACNA1I)
  • voltage-dependent T-type calcium channel subunit alpha-1I (LOC100555412)
  • calcium channel, voltage-dependent, alpha 1I subunit (Cacna1i)
  • calcium voltage-gated channel subunit alpha1 I (Cacna1i)
  • calcium channel, voltage-dependent, T type, alpha 1I subunit (cacna1i)
  • Ca(v)3.3 Protein
  • CACNA1L Protein
  • Cav3.3 Protein
  • si:ch211-51h13.1 Protein

Bezeichner auf Proteinebene für CACNA1I

alpha1I T-type calcium channel subunit , calcium channel, voltage-dependent, T type, alpha 1I subunit , voltage-dependent T-type calcium channel alpha-1I subunit , voltage-dependent T-type calcium channel subunit alpha-1I-like , low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I) , low-voltage-activated calcium channel alpha13.3 , calcium channel, voltage-dependent, alpha 1I subunit , voltage-dependent T-type calcium channel subunit alpha-1I , voltage-gated calcium channel subunit alpha Cav3.3 , caVT.3 , hypothetical gene supported by NM_020084 , voltage-dependent calcium channel

GENE ID SPEZIES
282413 Bos taurus
427900 Gallus gallus
458848 Pan troglodytes
708146 Macaca mulatta
100432497 Pongo abelii
100555412 Anolis carolinensis
100587399 Nomascus leucogenys
239556 Mus musculus
8911 Homo sapiens
56827 Rattus norvegicus
566351 Danio rerio
481243 Canis lupus familiaris
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