CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 Proteine (CTDSP1)

CTDSP1 encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. Zusätzlich bieten wir Ihnen CTDSP1 Antikörper (117) und CTDSP1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte CTDSP1 CTDSP1 363249  
CTDSP1 58190 Q9GZU7
CTDSP1 227292 P58466
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Showing 5 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
$492.31
Details

CTDSP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1) Interaktionspartnern

Human CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1) Interaktionspartner

  1. Our results provide a novel mechanistic insight into the activation of Myc (zeige MYC Proteine) by 27-HC via transcriptional repression of PP2A (zeige PPP2R4 Proteine), SCP1 (zeige SYCP1 Proteine) and FBW7 (zeige FBXW7 Proteine) to increase Myc (zeige MYC Proteine) protein stability in breast cancer cells.

  2. SCP1 (zeige SYCP1 Proteine) is the phosphatase that counterregulates the MAPK (zeige MAPK1 Proteine)-mediated phosphorylation of Ser (zeige SIGLEC1 Proteine)(68)-Twist1 (zeige TWIST1 Proteine).

  3. SCP1 (zeige SYCP1 Proteine) regulates c-Myc (zeige MYC Proteine) stability and functions through dephosphorylating c-Myc (zeige MYC Proteine) Serine-62.

  4. hSCP1 may be an beta-O-linked N-acetylglucosamine modified protein in vivo.

  5. CTDSP1 activity stabilizes REST in stem cells and ERK (zeige EPHB2 Proteine)-dependent phosphorylation combined with Pin1 (zeige PIN1 Proteine) activity promotes REST degradation in neural progenitors.

  6. SCP1 (zeige SYCP1 Proteine) phosphatase substrate specificity: CdcA3 (zeige CDCA3 Proteine) could be an enzymatic substrate for SCP1 (zeige SYCP1 Proteine).

  7. SCP1 (zeige SYCP1 Proteine) may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation

  8. results show that REST/NRSF (zeige REST Proteine) recruits SCPs to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells

  9. SCP1 (zeige SYCP1 Proteine) acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 (zeige GARS Proteine) and Smad2 (zeige SMAD2 Proteine).

Mouse (Murine) CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1) Interaktionspartner

  1. Consistently, the authors observed increased AKT (zeige AKT1 Proteine) phosphorylation and angiogenesis followed by enhanced tumorigenesis in Ctdsp1 (which encodes SCP1 (zeige CRISP1 Proteine)) gene - knockout mice. Importantly, they discovered that the membrane localization of SCP1 (zeige CRISP1 Proteine) is crucial for impeding angiogenesis and tumor growth, and this localization depends on palmitoylation of a conserved cysteine motif within its NH2 terminus.

  2. Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha (zeige PKCa Proteine)-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP.

  3. Findings suggest that SCP1 (zeige CRISP1 Proteine) may inhibit the osteoblastic differentiation induced by the BMP-Smad (zeige SMAD1 Proteine) axis via Runx2 (zeige RUNX2 Proteine) by suppressing downstream effector(s).

CTDSP1 Protein Überblick

Protein Überblick

This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit CTDSP1

  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 (CTDSP1)
  • CTD small phosphatase 1 (CTDSP1)
  • CTD small phosphatase 1 (Ctdsp1)
  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 (ctdsp1)
  • carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (HCAG_04820)
  • carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTRG_06220)
  • CTD small phosphatase 1 (ctdsp1)
  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 (Ctdsp1)
  • CTDSP1 Protein
  • fj83f12 Protein
  • GIP Protein
  • im:7141428 Protein
  • Nif3 Protein
  • NLI-IF Protein
  • NLIIF Protein
  • SCP1 Protein
  • wu:fj83f12 Protein
  • zgc:113169 Protein

Bezeichner auf Proteinebene für CTDSP1

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 , CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 , NLI-interacting factor 3 , nuclear LIM interactor-interacting factor 3 , small C-terminal domain phosphatase 1 , golli-interacting protein , small CTD phosphatase 1

GENE ID SPEZIES
608466 Canis lupus familiaris
516199 Bos taurus
459943 Pan troglodytes
363249 Rattus norvegicus
58190 Homo sapiens
553744 Danio rerio
5447218 Ajellomyces capsulatus NAm1
8301559 Candida tropicalis MYA-3404
100350904 Oryctolagus cuniculus
100380164 Xenopus (Silurana) tropicalis
227292 Mus musculus
100726065 Cavia porcellus
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