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Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.
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Human Monoclonal CRTC1 Primary Antibody für ICC, FACS - ABIN969066
Winnes, Mölne, Suurküla, Andrén, Persson, Enlund, Stenman: Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. in Genes, chromosomes & cancer 2007
Show all 3 Pubmed References
This work reveals a regulatory circuit in which SIK1 (zeige SIK1 Antikörper) suppresses gluconeogenic gene transcription by inducing ubiquitination and degradation of CRTC1.
CRTC1 negatively regulates lipogenic gene expression in liver.
findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 (zeige MAML2 Antikörper) gene fusion as a prognostic biomarker
modulation of rDNA transcription initiation, elongation and rRNA processing is an immediate, co-regulated response to altered amino acid abundance, dependent on both mTORC1 activation of S6K1 (zeige RPS6KB1 Antikörper) and MYC (zeige MYC Antikörper) activity
High TORC1 expression is associated with meningioma and schwannoma.
MECT1-MAML2 (zeige MAML2 Antikörper) fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma
CRTC1 as new mediator of PGE2 signaling
Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells
revealing neither correlation between the cellular composition and CRTC1-MAML2 (zeige MAML2 Antikörper) fusions nor presence of CRTC3 (zeige CRTC3 Antikörper)-MAML2 (zeige MAML2 Antikörper) fusions in cutaneous hidradenoma
CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals.
CRTC1 selectively plays protective role against nonalcoholic fatty liver disease development.CRTC1 also mediates anti-lipogenic effects of bile acid signaling, whereas it is negatively regulated by miR (zeige MLXIP Antikörper)-34a.
the HDAC3 (zeige HDAC3 Antikörper)-N-CoR (zeige NCOR1 Antikörper) corepressor complex leaves the Fgf1b (zeige FGF1 Antikörper) promoter and a complex involving the translocated CRTC1, phosphorylated CREB (zeige CREB1 Antikörper), and histone acetyltransferase (zeige HAT Antikörper) CBP (zeige CREBBP Antikörper) induces transient transcription.
Deletion of Raptor (zeige RPTOR Antikörper) reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro.
Three mouse CRTCs (Crtc1, Crtc2 (zeige CRTC2 Antikörper) and Crtc3 (zeige CRTC3 Antikörper)) exhibit distinct patterns of 14-3-3 (zeige YWHAQ Antikörper) binding at three conserved sites corresponding to S70, S171 (zeige NUMB Antikörper), and S275 (in CRTC2 (zeige CRTC2 Antikörper)).
The NR2B (zeige GRIN2B Antikörper)-CREB (zeige CREB1 Antikörper)-miR212/132-CRTC1-CREB (zeige CREB1 Antikörper) signal network plays an important role in the regulation of pain.
Findings reveal a critical role of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus during associative memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegeneration.
Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt (zeige AKT1 Antikörper) indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response
Study suggests that CRTC1 is a key regulator of behavioral and molecular response to antidepressant: CRTC1 is required for complete behavioral antidepressant response and for desipramine-induced expression of Bdnf (zeige BDNF Antikörper) and Nr4a1 (zeige NR4A1 Antikörper)-2. By acting downstream of CRTC1, the HDAC (zeige HDAC3 Antikörper) inhibitor SAHA improves the depressive-like behavior of Crtc1-/- mice.
IL-4 (zeige IL4 Antikörper) signaling co-opts the Akt (zeige AKT1 Antikörper)-mTORC1 pathway to regulate Acly (zeige ACLY Antikörper), a key enzyme in acetyl-CoA (zeige LPCAT1 Antikörper) synthesis, leading to increased histone acetylation and macrophage gene induction.
Upregulation of CRTC1 enhancing CREB (zeige CREB1 Antikörper)-dependent gene transcription in spinal cord may play an important role in bone cancer pain.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.
CREB-regulated transcription coactivator 1
, mucoepidermoid carcinoma translocated protein 1
, transducer of regulated cAMP response element-binding protein (CREB) 1
, mucoepidermoid carcinoma translocated 1
, mucoepidermoid carcinoma translocated protein 1 homolog
, transducer of CREB protein 1
, transducer of regulated cAMP response element-binding protein 1
, CREB regulated transcription coactivator 1
, CREB-regulated transcription coactivator 1-like
, CREB regulated transcription coactivator 1b
, cAMP-specific 3',5'-cyclic phosphodiesterase 4C
, phosphodiesterase 4C, cAMP-specific b