anti-CREB Regulated Transcription Coactivator 1 (CRTC1) Antikörper

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Zusätzlich bieten wir Ihnen CRTC1 Proteine (8) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CRTC1 23373 Q6UUV9
CRTC1 382056 Q68ED7
CRTC1 684527 Q157S1
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Top anti-CRTC1 Antikörper auf

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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB L1 rat brain, L2 human colon carcinoma lysates probed (ABIN746558) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band and observed band size: 73kDa HeLa cells probed with Rabbit Anti-Torc1 (Ser151) Polyclonal Antibody . 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
Rind (Kuh) Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 4 bis 8 Tage
Human Kaninchen Unkonjugiert IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: TORC1 Antibody [ABIN250744] - Section of human breast carcinoma. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of Torc1/Crtc1 (Phospho-Ser151) using PMA treated Jurkat whole cell lysates 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
Human Maus Unkonjugiert ELISA, FACS, ICC, WB Figure 1: Western blot analysis using CRTC1 mouse mAb against CRTC1(AA: 1-353)-hIgGFc transfected HEK293 cell lysate. Dilution: 1/500 - 1/2000 Figure 2: Immunofluorescence analysis of U251 (left) and NTERA2 (right) cells using CRTC1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. Dilution: 1/200 - 1/1000 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
Human Maus Unkonjugiert ELISA, FACS, IHC, IHC (p) Human Liver, Hepatocytes: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 11 bis 14 Tage
Human Maus Unkonjugiert ELISA, FACS, IF/ICC, WB 100 μL Anmelden zum Anzeigen 11 bis 16 Tage
Rind (Kuh) Kaninchen Unkonjugiert ELISA, IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with CRTC1 antibody ABIN214337 at 1:500 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-CRTC1 / MECT1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
Human Maus Unkonjugiert ELISA, WB   100 μL Anmelden zum Anzeigen 16 Days
Human Maus Unkonjugiert ELISA, WB   100 μL Anmelden zum Anzeigen 16 Days

Am meisten referenzierte anti-CRTC1 Antikörper

  1. Human Monoclonal CRTC1 Primary Antibody für ICC, FACS - ABIN969066 : Winnes, Mölne, Suurküla, Andrén, Persson, Enlund, Stenman: Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. in Genes, chromosomes & cancer 2007 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen CRTC1 Interaktionspartner

Human CREB Regulated Transcription Coactivator 1 (CRTC1) Interaktionspartner

  1. Pharmacological inhibition of mTORC1 by rapamycin in PHA-stimulated PBL reduced viral replication to the level found in unstimulated lymphocytes, indicating that mTORC1 activity supports MV replication as a proviral host factor.

  2. SNP located in CRTC1 has been shown in GWAS studies to be significantly associated with the risk of Barrett's esophagus.

  3. This work reveals a regulatory circuit in which SIK1 suppresses gluconeogenic gene transcription by inducing ubiquitination and degradation of CRTC1.

  4. CRTC1 negatively regulates lipogenic gene expression in liver.

  5. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker

  6. modulation of rDNA transcription initiation, elongation and rRNA processing is an immediate, co-regulated response to altered amino acid abundance, dependent on both mTORC1 activation of S6K1 and MYC activity

  7. High TORC1 expression is associated with meningioma and schwannoma.

  8. MECT1-MAML2 fusion transcript is a driver genetic event in the pathogenesis of primary bronchopulmonary mucoepidermoid carcinoma

  9. CRTC1 as new mediator of PGE2 signaling

  10. Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells

  11. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma

  12. CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals.

  13. DNA methylation levels within two distinct promoter regions of the CREB regulated transcription coactivator 1 gene were decreased in human hippocampus affected by Alzheimer disease.

  14. Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC diagnosis but is not associated with differences in survival outcomes.

  15. A specific CRTC1-MAMl2-induced transcriptional program was identified in mucoepidermoid carcinoma cells.

  16. Translocation t(11;19)(q14-21;p12-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13.

  17. This study showed that CREB-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication.

  18. CRTC1 activation is a key event that drives the LKB1-null mRNA signature in lung cancer. We also identified a positive feedback LKB1/CRTC1 signaling loop for COX-2/PGE2 regulation.

  19. describe fundamental metabolic requirements of senescent primary human CD8+ T cells and demonstrate that p38 MAPK blockade reverses senescence via an mTOR-independent pathway

  20. Malignant mucoepidermoid salivary gland tumors can arise from a recurrent t (11, 19)(q21;p13.1) translocation that generates an unusual chimeric CRTC1/MAML2 oncoprotein.

Mouse (Murine) CREB Regulated Transcription Coactivator 1 (CRTC1) Interaktionspartner

  1. Collectively, these findings highlight the male-specific involvement of CRTC1 in the central control of energy balance and circadian locomotor activity.

  2. CRTC1 selectively plays protective role against nonalcoholic fatty liver disease development.CRTC1 also mediates anti-lipogenic effects of bile acid signaling, whereas it is negatively regulated by miR-34a.

  3. the HDAC3-N-CoR corepressor complex leaves the Fgf1b promoter and a complex involving the translocated CRTC1, phosphorylated CREB, and histone acetyltransferase CBP induces transient transcription.

  4. Deletion of Raptor reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro.

  5. this study shows that mTORC1 activation is required for fueling B cells prior to dark zone proliferation rather than for allowing cell-cycle progression itself and must be regulated dynamically during cyclic re-entry to ensure efficient affinity-based selection

  6. Three mouse CRTCs (Crtc1, Crtc2 and Crtc3) exhibit distinct patterns of 14-3-3 binding at three conserved sites corresponding to S70, S171, and S275 (in CRTC2).

  7. The NR2B-CREB-miR212/132-CRTC1-CREB signal network plays an important role in the regulation of pain.

  8. Findings reveal a critical role of CREB-regulated transcription coactivator 1 (CRTC1) in the hippocampus during associative memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegeneration.

  9. Analysis of the successful model also elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt indirectly activates mTORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response

  10. Study suggests that CRTC1 is a key regulator of behavioral and molecular response to antidepressant: CRTC1 is required for complete behavioral antidepressant response and for desipramine-induced expression of Bdnf and Nr4a1-2. By acting downstream of CRTC1, the HDAC inhibitor SAHA improves the depressive-like behavior of Crtc1-/- mice.

  11. IL-4 signaling co-opts the Akt-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA synthesis, leading to increased histone acetylation and macrophage gene induction.

  12. Upregulation of CRTC1 enhancing CREB-dependent gene transcription in spinal cord may play an important role in bone cancer pain.

  13. This study demonstrates that TSC1- mechanistic target of rapamycin complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]

  14. These data identify Notch as a therapeutically actionable branch point of metabolic signaling at which Akt activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]

  15. aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 [mTORC1]

  16. CRTC1 has a wide impact on CREB-dpendent memory processes and fine-tunes CREB output in a region-specific manner.

  17. Translational activation of CREB is caused by elevated phospho-elF2alpha.

  18. PDK4 promotes tumorigenesis through activation of the CREB-RHEB-mTORC1 signaling cascade.

  19. mTORC1 activity is necessary and sufficient for the transition of satellite cells from G0 into G(Alert) and that signalling through the HGF receptor cMet is also necessary

  20. Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer Disease.

CRTC1 Antigen-Profil

Protein Überblick

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.

Genbezeichner und Symbole assoziert mit CRTC1

  • CREB regulated transcription coactivator 1 (CRTC1) Antikörper
  • CREB regulated transcription coactivator 1 (Crtc1) Antikörper
  • CREB regulated transcription coactivator 1 (crtc1) Antikörper
  • CREB regulated transcription coactivator 1b (crtc1b) Antikörper
  • AI413414 Antikörper
  • crtc1 Antikörper
  • fc68c05 Antikörper
  • Mect1 Antikörper
  • mKIAA0616 Antikörper
  • pde4cb Antikörper
  • R74955 Antikörper
  • si:ch211-255d18.1 Antikörper
  • si:ch211-255d18.8 Antikörper
  • TORC-1 Antikörper
  • TORC1 Antikörper
  • WAMTP1 Antikörper
  • wu:fc68c05 Antikörper

Bezeichner auf Proteinebene für CRTC1

CREB-regulated transcription coactivator 1 , mucoepidermoid carcinoma translocated protein 1 , transducer of regulated cAMP response element-binding protein (CREB) 1 , TORC-1 , mucoepidermoid carcinoma translocated 1 , mucoepidermoid carcinoma translocated protein 1 homolog , transducer of CREB protein 1 , transducer of regulated cAMP response element-binding protein 1 , CREB regulated transcription coactivator 1 , CREB-regulated transcription coactivator 1-like , CH211-255D18.10 , CH211-255D18.9 , CREB regulated transcription coactivator 1b , cAMP-specific 3',5'-cyclic phosphodiesterase 4C , phosphodiesterase 4C, cAMP-specific b , zfTorc1

23373 Homo sapiens
382056 Mus musculus
510465 Bos taurus
684527 Rattus norvegicus
720274 Macaca mulatta
735806 Pan troglodytes
771015 Gallus gallus
100036611 Xenopus (Silurana) tropicalis
100385682 Callithrix jacchus
100479645 Ailuropoda melanoleuca
100523662 Sus scrofa
100548464 Meleagris gallopavo
571344 Danio rerio
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