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CMTM6 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies.
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CMTM6 is present at the cell surface, associates with the PD-L1 (zeige CD274 ELISA Kits) protein, reduces its ubiquitination and increases PD-L1 (zeige CD274 ELISA Kits) protein half-life; CMTM6 enhances the ability of PD-L1 (zeige CD274 ELISA Kits)-expressing tumour cells to inhibit T cells; collectively, our data reveal that PD-L1 (zeige CD274 ELISA Kits) relies on CMTM6/4 to efficiently carry out its inhibitory function, and suggest potential new avenues to block this pathway
CMTM6 depletion, via the reduction of PD-L1 (zeige CD274 ELISA Kits), significantly alleviates the suppression of tumour-specific T cell activity in vitro and in vivo; findings provide insights into the biology of PD-L1 (zeige CD274 ELISA Kits) regulation, identify a previously unrecognized master regulator of this critical immune checkpoint and highlight a potential therapeutic target to overcome immune evasion by tumour cells
Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF gene families. The 8 family members were cloned and characterized.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.
CKLF-like MARVEL transmembrane domain-containing protein 6
, CKLF-like MARVEL transmembrane domain containing 6
, chemokine-like factor superfamily 6
, chemokine-like factor superfamily member 6
, chemokine-like factor super family 6