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Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity.
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Loss of CDS2 results in vascular-specific defects in vivo and failure of VEGFA (zeige VEGFA Antikörper)-induced angiogenesis in endothelial cells in vitro.
CDS1 (zeige CDS1 Antikörper) and CDS2 are important novel regulators of lipid storage.
distinct properties of the two isoforms of CDP (zeige CUX1 Antikörper)-diacylglycerol synthase
Cds2 showed a ubiquitous pattern of expression and was mapped to chromosome 2G1 (zeige YWHAZ Antikörper).
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13.
phosphatidate cytidylyltransferase 2
, CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
, phosphatidate cytidylyltransferase 2-like
, CDP-DAG synthase 2
, CDP-DG synthase 2
, CDP-DG synthetase 2
, CDP-diacylglycerol synthase 2
, CDP-diglyceride diphosphorylase 2
, CDP-diglyceride pyrophosphorylase 2
, CDP-diglyceride synthase 2
, CDP-diglyceride synthetase 2
, CDS 2
, CTP:phosphatidate cytidylyltransferase 2