CDK5 Regulatory Subunit Associated Protein 1-Like 1 Proteine (CDKAL1)

The protein encoded by CDKAL1 is a member of the methylthiotransferase family. Zusätzlich bieten wir Ihnen CDKAL1 Antikörper (50) und CDKAL1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CDKAL1 54901 Q5VV42
CDKAL1 68916 Q91WE6
Ratte CDKAL1 CDKAL1 361243  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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CDKAL1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) Interaktionspartnern

Human CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) Interaktionspartner

  1. More CDKAL1 variants are required to validate the association between CDKAL1 and gestational glycemic traits.

  2. Forced MT1E (zeige MT1E Proteine) expression rescues both hypersensitivity of CDKAL1 mutant cells to glycolipotoxicity and pancreatic beta-cell dysfunction in vitro and in vivo.

  3. CDKAL1 gene is associated with development of type 2 diabetes. For the HHEX (zeige HHEX Proteine)/IDE (zeige IDE Proteine) locus, such an association is absent.

  4. family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (zeige PTPRG Proteine), OSBPL6 (zeige OSBPL6 Proteine), and PDCL3 (zeige PDCL3 Proteine) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (zeige PTPRG Proteine), rs1347297 in the gene OSBPL6 (zeige OSBPL6 Proteine), and rs1513625 near PDCL3 (zeige PDCL3 Proteine). In addition, rs72953347 in OSBPL6 (zeige OSBPL6 Proteine) and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).

  5. The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX (zeige HHEX Proteine).

  6. Study provides evidence that SNPs of JMJD1C and KCNQ1 (zeige KCNQ1 Proteine) are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40.

  7. Our results suggest that rs6908425 in CDKAL1 is associated with the risk of developing SAPHO in Han Chinese populations. People who carry the risk allele T of rs6908425 might be more prone to developing SAPHO syndrome.

  8. We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO (zeige FTO Proteine)) with type 2 diabetes (T2D) in a Uyghur population

  9. our data suggested that CDKAL1 gene variants have a significant effect on the response to anti-TNF (zeige TNF Proteine) therapies among Psoriasis patients

  10. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (zeige ADCY5 Proteine), ADRA2A (zeige ADRA2A Proteine), CDKAL1, CDKN2A/B, GRB10 (zeige GRB10 Proteine), and TCF7L2 (zeige TCF7L2 Proteine)

Mouse (Murine) CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) Interaktionspartner

  1. CDKAL1 may affect such compensatory mechanisms regulating glucose homeostasis through interaction with diet

  2. Knockout mice with pancreatic beta-cell-specific lack of cdkal1 show pancreatic islet hypertrophy and impaired blood glucose control.

  3. Data show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys (zeige LYZ Proteine))(UUU) and that it is required for the accurate translation of AAA (zeige AAAS Proteine) and AAG (zeige C16orf35 Proteine) codons.

  4. CDKAL1 controls first-phase insulin (zeige INS Proteine) exocytosis in beta cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2 (zeige CA2 Proteine)+) channels through pathways other than CDK5 (zeige CDK5 Proteine)-mediated regulation

CDKAL1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes.

Genbezeichner und Symbole assoziert mit CDKAL1

  • CDK5 regulatory subunit associated protein 1 like 1 (CDKAL1)
  • CDK5 regulatory subunit associated protein 1-like 1 (cdkal1)
  • CDK5 regulatory subunit associated protein 1-like 1 S homeolog (cdkal1.S)
  • threonylcarbamoyladenosine tRNA methylthiotransferase (LOC587594)
  • CDK5 regulatory subunit associated protein 1-like 1 (Cdkal1)
  • 1190005B03Rik Protein
  • 6620401C13Rik Protein
  • MGC76088 Protein
  • MGC78779 Protein
  • zgc:65864 Protein

Bezeichner auf Proteinebene für CDKAL1

CDK5 regulatory subunit-associated protein 1-like 1 , tRNA-t(6)A37 methylthiotransferase , threonylcarbamoyladenosine tRNA methylthiotransferase , CDK5 regulatory subunit associated protein 1-like 1

GENE ID SPEZIES
100052309 Equus caballus
393600 Danio rerio
394802 Xenopus (Silurana) tropicalis
420823 Gallus gallus
432014 Xenopus laevis
530159 Bos taurus
587594 Strongylocentrotus purpuratus
747778 Pan troglodytes
100024680 Monodelphis domestica
54901 Homo sapiens
488240 Canis lupus familiaris
68916 Mus musculus
361243 Rattus norvegicus
100512355 Sus scrofa
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