anti-CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) Antikörper

The protein encoded by CDKAL1 is a member of the methylthiotransferase family. Zusätzlich bieten wir Ihnen CDKAL1 Kits (4) und CDKAL1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CDKAL1 54901 Q5VV42
CDKAL1 68916 Q91WE6
CDKAL1 361243  
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Top anti-CDKAL1 Antikörper auf antikoerper-online.de

Showing 10 out of 50 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), IHC, WB Western Blot: CDKAL1 Antibody [NBP1-32796] - A. 30 ug Jurkat whole cell lysate/extract, B. 30 ug Raji whole cell lysate/extract, C. 30 ug K562 whole cell lysate/extract 7. 5 % SDS-PAGE gel, antibody dilution 1:1000. Western Blot: CDKAL1 Antibody [NBP1-32796] - Sample (30 ug of whole cell lysate) A:NIH-3T3 7.5% SDS PAGE diluted at 1:2000 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Kaninchen Unkonjugiert ELISA, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
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Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
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Human Ziege Unkonjugiert ELISA, WB   0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Lane 1: rat brain lysates Lane 2: rat liver lysates probed with Anti CDKAL1 Polyclonal Antibody, Unconjugated (ABIN873056) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 65kD. Observed band size: 65kD. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details
Fledermaus Ziege Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details
Human Kaninchen Unkonjugiert IF/ICC, WB Western blot analysis of extracts of various cell lines, using CDKAL1 antibody (ABIN5973393) at 1/1000 dilution. 100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
Details
Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cell lines, using CDKAL1 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details

Am meisten referenzierte anti-CDKAL1 Antikörper

  1. Human Polyclonal CDKAL1 Primary Antibody für ELISA, WB - ABIN570672 : Brambillasca, Altkrueger, Colombo, Friederich, Eickelmann, Mark, Borgese, Solimena: CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. in The Journal of biological chemistry 2012 (PubMed)

  2. Dog (Canine) Polyclonal CDKAL1 Primary Antibody für ELISA - ABIN451799 : Zeggini, Weedon, Lindgren, Frayling, Elliott, Lango, Timpson, Perry, Rayner, Freathy, Barrett, Shields, Morris, Ellard, Groves, Harries, Marchini, Owen, Knight, Cardon, Walker, Hitman, Morris, Doney et al.: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. ... in Science (New York, N.Y.) 2007 (PubMed)

Weitere Antikörper gegen CDKAL1 Interaktionspartner

Human CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) Interaktionspartner

  1. Non-significant association was seen in the two single nucleotide polymorphisms (SNPs) of CDKAL1 (rs7754840) and CDKN2A/2B (rs10811661) with gestational diabetes mellitus (GDM).

  2. chromosomal region 6p22.3 is a novel susceptibility locus for nsCL (zeige NHLH1 Antikörper)/P. The location of the risk variants within the CDKAL1 intronic sequence containing enhancer elements predicted to regulate the SOX4 transcription may suggest that SOX4, rather than CDKAL1, is a potential candidate gene for this craniofacial anomaly.

  3. More CDKAL1 variants are required to validate the association between CDKAL1 and gestational glycemic traits.

  4. Forced MT1E (zeige MT1E Antikörper) expression rescues both hypersensitivity of CDKAL1 mutant cells to glycolipotoxicity and pancreatic beta-cell dysfunction in vitro and in vivo.

  5. CDKAL1 gene is associated with development of type 2 diabetes. For the HHEX (zeige HHEX Antikörper)/IDE (zeige IDE Antikörper) locus, such an association is absent.

  6. family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (zeige PTPRG Antikörper), OSBPL6 (zeige OSBPL6 Antikörper), and PDCL3 (zeige PDCL3 Antikörper) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (zeige PTPRG Antikörper), rs1347297 in the gene OSBPL6 (zeige OSBPL6 Antikörper), and rs1513625 near PDCL3 (zeige PDCL3 Antikörper). In addition, rs72953347 in OSBPL6 (zeige OSBPL6 Antikörper) and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).

  7. The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX (zeige HHEX Antikörper).

  8. Study provides evidence that SNPs of JMJD1C (zeige JMJD1C Antikörper) and KCNQ1 (zeige KCNQ1 Antikörper) are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40.

  9. Our results suggest that rs6908425 in CDKAL1 is associated with the risk of developing SAPHO in Han Chinese populations. People who carry the risk allele T of rs6908425 might be more prone to developing SAPHO syndrome.

  10. We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO (zeige FTO Antikörper)) with type 2 diabetes (T2D) in a Uyghur population

Mouse (Murine) CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) Interaktionspartner

  1. CDKAL1 may affect such compensatory mechanisms regulating glucose homeostasis through interaction with diet

  2. Knockout mice with pancreatic beta-cell-specific lack of cdkal1 show pancreatic islet hypertrophy and impaired blood glucose control.

  3. Data show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys (zeige LYZ Antikörper))(UUU) and that it is required for the accurate translation of AAA (zeige AAAS Antikörper) and AAG (zeige C16orf35 Antikörper) codons.

  4. CDKAL1 controls first-phase insulin (zeige INS Antikörper) exocytosis in beta cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2 (zeige CA2 Antikörper)+) channels through pathways other than CDK5 (zeige CDK5 Antikörper)-mediated regulation

CDKAL1 Antigen-Profil

Protein Überblick

The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes.

Genbezeichner und Symbole assoziert mit CDKAL1

  • CDK5 regulatory subunit associated protein 1 like 1 (CDKAL1) Antikörper
  • CDK5 regulatory subunit associated protein 1-like 1 (cdkal1) Antikörper
  • CDK5 regulatory subunit associated protein 1-like 1 S homeolog (cdkal1.S) Antikörper
  • threonylcarbamoyladenosine tRNA methylthiotransferase (LOC587594) Antikörper
  • CDK5 regulatory subunit associated protein 1-like 1 (Cdkal1) Antikörper
  • 1190005B03Rik Antikörper
  • 6620401C13Rik Antikörper
  • MGC76088 Antikörper
  • MGC78779 Antikörper
  • zgc:65864 Antikörper

Bezeichner auf Proteinebene für CDKAL1

CDK5 regulatory subunit-associated protein 1-like 1 , tRNA-t(6)A37 methylthiotransferase , threonylcarbamoyladenosine tRNA methylthiotransferase , CDK5 regulatory subunit associated protein 1-like 1

GENE ID SPEZIES
100052309 Equus caballus
393600 Danio rerio
394802 Xenopus (Silurana) tropicalis
420823 Gallus gallus
432014 Xenopus laevis
530159 Bos taurus
587594 Strongylocentrotus purpuratus
747778 Pan troglodytes
100024680 Monodelphis domestica
54901 Homo sapiens
488240 Canis lupus familiaris
68916 Mus musculus
361243 Rattus norvegicus
100512355 Sus scrofa
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