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The protein encoded by CDC14B is a member of the dual specificity protein tyrosine phosphatase family. Zusätzlich bieten wir Ihnen CDC14 Cell Division Cycle 14 Homolog B (S. Cerevisiae) Antikörper (40) und und viele weitere Produktgruppen zu diesem Protein an.
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Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
Cdc14B has oncogenic activity in mammals and point to the Ras-MAP kinase pathway as a major effector pathway during oncogenic transformation.
Cdc14b is required for efficient DNA damage repair.
CDC14B is a negative regulator of the 1-to-2-cell transition and of zygotic genome activation in mouse embryogenesis.
CDC14B is a negative regulator of meiotic resumption and may regulate meiosis I in mouse oocytes.
The authors found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer) in patients with medullary thyroid cancer.
hCdc14B promotes reactivation of rDNA transcription by dephosphorylating TAFI110. SIRT1 becomes transiently enriched in nucleoli at the onset of mitosis. SIRT1 deacetylates TAFI68 destabilizing SL1 binding to the rDNA promoter
CDC14B expression is downregulated in clear cell renal carinoma, suggesting its role in renal carcinogenesis
CDC (cell division cycle) 14A/B phosphatases associate with KIBRA, and CDK1-non-phosphorylatable KIBRA has greatly reduced interaction with CDC14B.
studies have revealed a novel interplay between Chk1 kinase and Cdc14B phosphatase involving radiation-induced nucleolar shuttling to facilitate error-free cell cycle progression and prevent genomic instability
Cdc14B-dependent modulation of Cdc25 phosphatase and Cdk1/cyclin B activity is linked to correct chromosome segregation and bipolar spindle formation, processes that are required for proper progression through mitosis and maintenance of genomic stability.
human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14B are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation.
Cdc14B is critical for the maintenance of proper nuclear structure.
CDC14B is a novel microtubule-bundling and -stabilizing protein, whose regulated subcellular localization may help modulate spindle and microtubule dynamics in mitosis.
hCdc14A and hCdc14B have functional homology to S. pombe Cdc25 and flp1
Our findings reveal substantial divergence in mitotic regulation between yeast and mammalian cells, as the latter possess efficient mechanisms for completing late M-phase events in the absence of a nucleolar Cdc14-related phosphatase.
Results suggest a potential function for Cdc14B phosphatase in maintaining the fidelity of centrosome duplication cycle.
In response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(Cdh1), with the consequent degradation of Plk1, a prominent mitotic kinase.
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
Dual specificity protein phosphatase CDC14B
, dual specificity protein phosphatase CDC14B
, CDC14 homolog B
, CDC14 cell division cycle 14 homolog B (S. cerevisiae)
, dual specificity protein phosphatase CDC14B-like
, CDC14 cell division cycle 14 homolog B