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The protein encoded by CDC14B is a member of the dual specificity protein tyrosine phosphatase family. Zusätzlich bieten wir Ihnen CDC14 Cell Division Cycle 14 Homolog B (S. Cerevisiae) Antikörper (40) und und viele weitere Produktgruppen zu diesem Protein an.
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Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A (zeige CDC14A Proteine) levels were low.
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
Cdc14B has oncogenic activity in mammals and point to the Ras-MAP kinase (zeige MAPK1 Proteine) pathway as a major effector pathway during oncogenic transformation.
Cdc14b is required for efficient DNA damage repair.
CDC14B is a negative regulator of the 1-to-2-cell transition and of zygotic genome activation in mouse embryogenesis.
CDC14B is a negative regulator of meiotic resumption and may regulate meiosis I in mouse oocytes.
hCdc14B promotes reactivation of rDNA transcription by dephosphorylating TAFI110 (zeige TAF1C Proteine). SIRT1 (zeige SIRT1 Proteine) becomes transiently enriched in nucleoli at the onset of mitosis. SIRT1 (zeige SIRT1 Proteine) deacetylates TAFI68 destabilizing SL1 (zeige MMP3 Proteine) binding to the rDNA promoter
CDC14B expression is downregulated in clear cell renal carinoma, suggesting its role in renal carcinogenesis
CDC (zeige CDK1 Proteine) (cell division cycle) 14A/B phosphatases associate with KIBRA (zeige WWC1 Proteine), and CDK1 (zeige CDK1 Proteine)-non-phosphorylatable KIBRA (zeige WWC1 Proteine) has greatly reduced interaction with CDC14B.
studies have revealed a novel interplay between Chk1 (zeige CHEK1 Proteine) kinase and Cdc14B phosphatase involving radiation-induced nucleolar shuttling to facilitate error-free cell cycle progression and prevent genomic instability
Cdc14B-dependent modulation of Cdc25 (zeige RASGRF1 Proteine) phosphatase and Cdk1 (zeige CDK1 Proteine)/cyclin B activity is linked to correct chromosome segregation and bipolar spindle formation, processes that are required for proper progression through mitosis and maintenance of genomic stability.
human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14B are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation.
Cdc14B is critical for the maintenance of proper nuclear structure.
CDC14B is a novel microtubule-bundling and -stabilizing protein, whose regulated subcellular localization may help modulate spindle and microtubule dynamics in mitosis.
hCdc14A and hCdc14B have functional homology to S. pombe Cdc25 and flp1
Our findings reveal substantial divergence in mitotic regulation between yeast and mammalian cells, as the latter possess efficient mechanisms for completing late M-phase events in the absence of a nucleolar Cdc14 (zeige CDC14A Proteine)-related phosphatase.
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
Dual specificity protein phosphatase CDC14B
, dual specificity protein phosphatase CDC14B
, CDC14 homolog B
, CDC14 cell division cycle 14 homolog B (S. cerevisiae)
, dual specificity protein phosphatase CDC14B-like
, CDC14 cell division cycle 14 homolog B