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glycosylphosphatidylinositol (GPI)-anchored cell surface antigen [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen CD52 Antikörper (196) und CD52 Kits (17) und viele weitere Produktgruppen zu diesem Protein an.
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Soluble CD52 is used by certain CD4 (zeige CD4 Proteine)-positive cells to suppress target celss via the inhibitory receptor Siglec-10 (zeige SIGLEC10 Proteine).
Genetic background determines the requirement for B7 costimulation in autoimmunity induction. Backcrossed B7.1/B7.2 (zeige CD86 Proteine) deficient (-/-)mice on C57BL/6 (B6) or SJL backgrounds had different susceptibility to induced experimental autoimmune encephalomyelitis.
study examined the tissue distribution, molecular composition and immunogenicity of mouse male reproductive tract-CD52
The results indicate CD52 is not required for fertilization in the mouse either in vivo or in vitro.
Study helps to precisely define CD52 expression in the tumor cell population of PTCL and might therefore be valuable when evaluating the response to alemtuzumab therapy in prospective clinical trials.
soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR.
CD52 is a novel prognostic NSC marker and a potential NSC target in a subset of patients with MDS (zeige PAFAH1B1 Proteine) and AML (zeige RUNX1 Proteine), which may have clinical implications and may explain clinical effects produced by alemtuzumab in these patients.
A molecular and computational diagnostic approach identifies FOXP3 (zeige FOXP3 Proteine), ICOS (zeige CTLA4 Proteine), CD52 and CASP1 (zeige CASP1 Proteine) as the most informative biomarkers in acute graft-versus-host disease.
CT60 single-nucleotide polymorphism of CTLA4 (zeige CTLA4 Proteine) is a surrogate marker for donor lymphocyte infusion outcome after allogeneic cell transplantation for acute leukemia
Clonal large granular lymphocytes exhibited decreased CD52 expression post-therapy in patients refractory to treatment.
Our bioinformatics findings suggest that CD52 polymorphism may affect the efficiency of GPI (zeige GNPDA1 Proteine) anchor formation and thus may indirectly alter the response to anti-CD52 agents like alemtuzumabin renal transplantation.
Review article on CD52 structure and function.
HE5(CD52) mRNA and protein, expressed in epithelial cells of the distal epididymis, were not affected by the obstruction of the vas (zeige AVP Proteine) deferens.
The relationship between this differential insertion and differences in glycosylation of rat and human CD52 is discussed.
CD52 is widely expressed on human mast cells (MCs (zeige SMCP Proteine)) and Waldenstrom's Macroglobulinemia bone marrow lymphoplasmacytic cells and provide the preclinical rationale for the use of alemtuzumab in the treatment of WM and possibly other MC-related disorders.
glycosylphosphatidylinositol (GPI)-anchored cell surface antigen
, CD52 antigen
, CAMPATH-1 antigen
, lymphocyte differentiation antigen B7
, CD52 antigen (CAMPATH-1 antigen)
, CDW52 antigen (CAMPATH-1 antigen)
, cambridge pathology 1 antigen
, epididymal secretory protein E5
, human epididymis-specific protein 5