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CD47 encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Zusätzlich bieten wir Ihnen CD47 Antikörper (320) und CD47 Proteine (52) und viele weitere Produktgruppen zu diesem Protein an.
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Mechanistic studies suggest a PKC (zeige PKC ELISA Kits)-Syk (zeige SYK ELISA Kits)-mediated signaling pathway, to which IL-10 (zeige IL10 ELISA Kits) conversely inhibits, is required for activating macrophage self-targeting, followed by phagocytosis independent of calreticulin (zeige CALR ELISA Kits) Moreover, we identified spleen red pulp to be one specific tissue that provides stimuli constantly activating macrophage phagocytosis albeit lacking in Cd47(-/-) or Sirpalpha(-/-) mice.
mice deficient in CD47 (CD47 Knockout) had significantly less brain neutrophil infiltration at 24h, upregulated VEGF (zeige VEGFA ELISA Kits) expression in peri (zeige POSTN ELISA Kits)-lesion cortex at 7 and 14day
TSP1 (zeige GZMA ELISA Kits) significantly accelerates replicative senescence and associated cell cycle arrest in a CD47-dependent manner.
CD47, TSP1 (zeige GZMA ELISA Kits), and to a lesser extent SIRPalpha facilitate exosome-mediated myeloid-derived suppressor cells chemotaxis and migration.
In pulmonary hypertension TSP1 (zeige GZMA ELISA Kits)-CD47 is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
thrombospondin-1 (zeige THBS1 ELISA Kits) via CD47 inhibits renal tubular epithelial cell recovery after ischemia reperfusion injury through inhibition of proliferation/self-renewal.
these findings have demonstrated how tumor cells inhibit innate sensing in dendritic cells and suggested that the CD47-SIRPalpha axis is critical for dendritic cell-driven antitumor immunity
this study shows that CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis
the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (zeige GZMA ELISA Kits)/CD47 axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
These results identify CD47 as an important regulator of LFA-1 (zeige ITGAL ELISA Kits) and VLA-4 integrin-adhesive functions in T cell proliferation.
TTI-621 (SIRPalphaFc) is a fully human recombinant fusion protein that blocks the CD47-SIRPalpha axis by binding to human CD47 and enhancing phagocytosis of malignant cells..These data indicate that TTI-621 is active across a broad range of human tumors.
this review highlights the various functions of CD47, discusses anti-tumor responses generated by both the innate and adaptive immune systems as a consequence of administering anti-CD47 blocking antibody, and finally elaborates on the clinical potential of CD47 blockade.
we observed neutrophilic infiltration was slightly increased in anti-CD47 treated tumors compared to IgG control.
In pulmonary hypertension TSP1 (zeige THBS1 ELISA Kits)-CD47 is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
Engineering macrophages to eat cancer: from "marker of self" CD47 and phagocytosis to differentiation
the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (zeige THBS1 ELISA Kits)/CD47 axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
Results indicated that surgical resection combined with anti-CD47 blocking immunotherapy promoted an inflammatory response and prolonged survival in xenograft animal model, and is therefore an attractive strategy for clinical translation.
Results show that the stronger expression of CD47 by cancer cells and larger number of total macrophages/M2 were independently related to shorter survivals.
Prolongation of transient porcine chimerism via transgenic expression of human CD47 in a primate model is associated with an immune modulating effect, leading to markedly prolonged survival of donor swine skin xenografts.
Amyloid-beta inhibits No-cGMP signaling in a CD36 (zeige CD36 ELISA Kits)- and CD47-dependent manner
Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection.
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.
, integrin-associated protein
, leukocyte surface antigen CD47
, CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
, CD47 glycoprotein
, antigen identified by monoclonal antibody 1D8
, antigenic surface determinant protein OA3
, integrin associated protein
, integrin-associated signal transducer
, CD47 antigen