CD2-Associated Protein (Cd2ap) ELISA Kits

Cd2ap encodes a scaffolding molecule that regulates the actin cytoskeleton. Zusätzlich bieten wir Ihnen CD2-Associated Protein Antikörper (57) und CD2-Associated Protein Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Cd2ap 23607 Q9Y5K6
Cd2ap 12488 Q9JLQ0
Anti-Ratte Cd2ap Cd2ap 316258  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 4.7 pg/mL 18.75-1200 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
Maus < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage

Weitere ELISA Kits für CD2-Associated Protein Interaktionspartner

Zebrafish CD2-Associated Protein (Cd2ap) Interaktionspartner

  1. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

Human CD2-Associated Protein (Cd2ap) Interaktionspartner

  1. CD2AP is an sporadic-Alzheimer's-disease risk gene in a southern Chinese Han population.

  2. data suggest that CD2AP acts as a negative regulator of ICAM-1 clustering, which limits the formation of ICAM-1 adhesion complexes to prevent uncontrolled neutrophil adhesion and transcellular transmigration.

  3. CD2AP expression in renal tubules may histologically associate with tissue hypoxia and reflected recovery from CsA-mediated renal injury in nephrotic syndrome patients.

  4. data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively.

  5. Silencing Cindr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span, as well as collapse of nephrocyte lacunar channels and effacement of nephrocyte slit diaphragms. These phenotypes could be rescued by expression of a wild-type human CD2AP gene, but not a mutant allele derived from a patient with CD2AP-associated NS.

  6. Study found a novel association of CD2AP with plasma homocysteine in participants with African ancestry and found a new variant in the candidate gene CBS associated with homocysteine

  7. CD2AP rs9349407 polymorphism contributes to Alzheimer's disease susceptibility.

  8. discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL, ALIX, and RIN3

  9. we present the first demonstration that the purified SH3 domains of the CD2AP/Cin85 protein family are able to directly bind the p53 protein, and to discriminate between the two polymorphic variants P72R

  10. CD2-Associated Protein affects Abeta levels and Abeta42/Abeta40 ratio in vitro

  11. CD2AP gene variants may contribute to susceptibility to end-stage renal disease in patients with type 1 diabetes.

  12. FSGS3/CD2AP has a role of barbed-end capping in junctional actin dynamics.

  13. an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings

  14. E2F1 up-regulates the human CD2AP promoter.

  15. CD2AP is highly expressed in human plasmacytoid dendritic cells (DC) and positively regulates blood DC antigen 2 (BDCA2)/Fc fragment of IgE high affinity I receptor (FcepsilonR1gamma) signaling.

  16. identifies CD2AP as the gatekeeper of the podocyte TGF-beta response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease

  17. The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy.

  18. found that the N-terminal SH3 domain of both adaptor proteins CD2AP and CIN85 are the most stable SH3 domains that have been studied until now

  19. found independent evidence for association for Alzheimer's disease susceptibility loci at EPHA1, CD33 and CD2AP

  20. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Mouse (Murine) CD2-Associated Protein (Cd2ap) Interaktionspartner

  1. Ang II induces the relocalization and reduction of CD2AP via AT1R, which would cause podocyte apoptosis by the suppression of CD2AP/PI3-K signaling

  2. Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP.

  3. Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta in neurons increasing the risk for late-onset AD.

  4. CD2AP forms a complex with GGA2, a clathrin adaptor, which sorts Glut4 to GSVs, suggesting a role for CD2AP in this process.

  5. CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting

  6. CD2AP has role in mediating blood-brain barrier integrity and cerebrovascular roles of CD2AP could contribute to its effects on Alzheimer's disease risk.

  7. CD2-Associated Protein affects Abeta levels and Abeta42/Abeta40 ratio in vitro

  8. only the SH3 domains of CD2AP are necessary to enhance the E3 ligase activity of Cbl-3/c toward Ret51

  9. CD2AP is not involved in the regulation of type I IFNs in plasmacytoid dendritic cells. Its major function is on the actin cytoskeleton, affecting migration to local lymph nodes under conditions of inflammation.

  10. CD2AP deficiency results in the excretion of intact albumin in knockout mice.

  11. the formation of lamellipodia is mediated by a complex of cortactin, CD2AP, and actin capping protein

  12. These data descrived the importance of concomitant decreases in podocin, CD2AP and tensin2 during septic acute renal failure-associated proteinuria.

  13. Sh3kbp1 is SUMOylated by SUMO-1, -2, and -3 and that SUMOylation is enhanced in the presence of Cd2ap.

  14. identifies CD2AP as the gatekeeper of the podocyte TGF-beta response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease

  15. Coexpression of CIN85/Ruk(L) with CD2AP led to a decreased binding of CIN85/Ruk(L) to nephrin and podocin, which indicates a functional competition between CD2AP and CIN85/Ruk(L).

  16. CD2AP is expressed in glomerular podocytes, and may play a role in a specialized adhesion complex known as the slit diaphragm.

  17. Cd2ap is involved in the regulation of the actin cytoskeleton and may act as a direct adapter between the actin cytoskeleton and cell membrane proteins

  18. mice with CD2AP haploinsufficiency developed glomerular changes at 9 months of age and had increased susceptibility to glomerular injury by nephrotoxic antibodies or immune complexes

  19. CD2-associated protein has a role in transforming growth factor-beta-induced apoptosis

  20. CD2AP associated with dynamic actin in specific late endosomal compartment in podocytes, suggesting CD2AP might be crucially involved in endosomal sorting and/or trafficking via regulation of actin assembly on vesicles

CD2-Associated Protein (Cd2ap) Antigen-Profil

Beschreibung des Gens

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

Genbezeichner und Symbole assoziert mit Cd2ap

  • CD2-associated protein L homeolog (cd2ap.L) Antikörper
  • CD2 associated protein (CD2AP) Antikörper
  • CD2-associated protein (cd2ap) Antikörper
  • CD2 associated protein (cd2ap) Antikörper
  • CD2-associated protein (Cd2ap) Antikörper
  • CD2 associated protein (Cd2ap) Antikörper
  • AL024079 Antikörper
  • C78928 Antikörper
  • cd2apl Antikörper
  • CMS Antikörper
  • DKFZp469E061 Antikörper
  • fj51c01 Antikörper
  • im:7153970 Antikörper
  • METS-1 Antikörper
  • Mets1 Antikörper
  • si:ch211-207n9.1 Antikörper
  • wu:fj51c01 Antikörper
  • zgc:103705 Antikörper

Bezeichner auf Proteinebene für Cd2ap

CD2-associated protein , Cas ligand with multiple Src homology 3 (SH3) domains , adapter protein CMS , cas ligand with multiple SH3 domains , hypothetical protein , SH3 domain-containing adapter protein , SH3 domain-containing adaptor protein METS-1 , mesenchyme to epithelium transition protein, SH3 domains , mesenchyme-to-epithelium transition protein with SH3 domains 1

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