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Plays a role in the deadenylation of mRNAs in the cytoplasm.
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Structural analysis shows that all inhibitors occupy the substrate and magnesium-binding sites of CNOT6L, suggesting that inhibitors compete with both substrate and divalent magnesium ions for overlapping binding sites.
Data show that CNOT6L protein-interleukin 8 (IL-8 (zeige IL8 Antikörper)) is a signaling axis in myogenesis.
Cnot6L, a validated target of miR (zeige MLXIP Antikörper)-146a, affects the stability of Zeb1 (zeige ZEB1 Antikörper) mRNA.
Results identified CNOT6 (zeige CNOT6 Antikörper)/CNOT6L as a key regulator of insulin-like growth factor-binding protein 5 (zeige IGFBP5 Antikörper), which mediates cell cycle arrest and senescence via a p53 (zeige TP53 Antikörper)-dependent pathway.
show that the nuclease (zeige DCLRE1C Antikörper) domain of CNOT6L exhibits full Mg(2 (zeige MUC7 Antikörper)+)-dependent deadenylase activity with strict poly(A) RNA substrate specificity.
CCR4b may be involved in various cellular events that include cell proliferation.
Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation- dependent degradation of CDKN1B mRNA (By similarity).
CCR4-NOT transcription complex subunit 6-like
, carbon catabolite repressor protein 4 homolog B