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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Zusätzlich bieten wir Ihnen CTCF Antikörper (95) und CTCF Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (zeige RUNX1 ELISA Kits) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis.
CTCF physically associates with Wdr5 and further transcriptionally controls its expression by directly targeting the Wdr5 gene promoter.
Since CTCF and cohesin are required for loop domain formation, our results suggest that chromatin loops are dynamic and frequently break and reform throughout the cell cycle.
Nearly half of all DNase hypersensitivity sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 (zeige RUNX2 ELISA Kits) and/or the chromatin-related CTCF transcription factors.
Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites.
CTCF knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF (zeige BDNF ELISA Kits) and Arc loci.
CTCF mediates local regulatory interactions to coordinate transcriptional programs controlling transitions in morphology and function during heart development.
Long-range promoter-enhancer interaction mediated by CTCF plays important roles in controlling the cell-to-cell variation of gene expression in mammalian cells.
n keratinocytes, the promoter-enhancer anchoring regions in the gene-rich transcriptionally active TADs are enriched for the binding of chromatin architectural proteins CTCF, Rad21 and chromatin remodeler Brg1. In contrast to gene-rich TADs, gene-poor TADs show preferential spatial contacts with each other, do not contain active enhancers and show decreased binding of CTCF, Rad21 and Brg1 in keratinocytes
CTCF mediated chromatin structural modulation and regulates Hoxc gene expression.
CTCF can regulate V(D)J recombination by segregating recombination signal sequences (RSSs) into distinct loop domains and inhibiting RSS (zeige GRB10 ELISA Kits) synapsis, independent of any effects on transcription, RSS (zeige GRB10 ELISA Kits) accessibility, and RAG recombinase (zeige RAG1 ELISA Kits) tracking
The MeCP2, a protein whose mutated forms are involved in Rett syndrome; and CTCF, a constitutive transcriptional insulator.
The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL.
CTCF-FOXM1 (zeige FOXM1 ELISA Kits) axis regulates tumour growth and metastasis in hepatocellular carcinoma cells.
we show CTCF binding site mutations to be functional by demonstrating allele-specific reduction of CTCF binding to mutant alleles. While topologically associating domains with mutated CTCF anchors in melanoma contain differentially expressed cancer-associated genes, CTCF motif mutations appear generally under neutral selection
CTCF-mediated long-range interactions are integral for a multitude of topological features of interphase chromatin, such as the formation of topologically associated domains, domain insulation, enhancer blocking and even enhancer function.
Authors have identified two novel pro-tumorigenic roles (promoting cell survival and altering cell polarity) for genetic alterations of CTCF in endometrial cancer.
Describe several protein-DNA complex structures of a human CTCF tandem zinc-finger array, explaining the adaptability of CTCF to sequence variations and the positiondependent effect of differential DNA methylation at two cytosine residues, and revealing a potential function of C-terminal ZF8 and ZF9 spanning across the DNA phosphate backbone.
CCCTC-binding factor (CTCF) targets the binding sites within MYCN (zeige MYCN ELISA Kits) promoter to facilitate its expression in neuroblastoma (NB) cells.
we review recent high-resolution chromosome conformation capture and functional studies that have informed models of the spatial and regulatory compartmentalization of mammalian genomes, and discuss mechanistic models for how CTCF and cohesin control the functional architecture of mammalian chromosomes.
GAD1 (zeige GAD1 ELISA Kits) is reactivated by DNA methylation, which provided a model for DNA methylation and the active orchestration of oncogenic gene expression by CTCF in cancer cells.
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor