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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. Zusätzlich bieten wir Ihnen CTCF Antikörper (105) und CTCF Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (zeige RUNX1 ELISA Kits) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis.
CCCTC-binding factor CTCF supports the homeostatic maintenance of hematopoietic stem cell (HSCs) pools by sustaining HSC quiescence in a reactive oxygen species ROS (zeige ROS1 ELISA Kits)-dependent manner.
Authors show that mice devoid of an inducible CTCF binding element, located in the alpha constant gene, display a marked isotype-specific increase of GL transcription in developing and resting splenic B cells and altered CSR in activated B cells.
The study provides evidence that CTCF regulates chromatin organization during spermiogenesis, contributing to the functional organization of mature sperm.
CTCF Binding Sites in the Herpes Simplex Virus 1 Genome Display Site-Specific CTCF Occupation, Protein Recruitment, and Insulator Function.
Both LDB1 (zeige LDB1 ELISA Kits) and CTCF are required for enhancer-Car2 (zeige CA2 ELISA Kits) looping, and the domain of LDB1 (zeige LDB1 ELISA Kits) contacted by CTCF is necessary to rescue Car2 (zeige CA2 ELISA Kits) transcription in LDB1 (zeige LDB1 ELISA Kits)-deficient cells.
CTCF physically associates with Wdr5 (zeige WDR5 ELISA Kits) and further transcriptionally controls its expression by directly targeting the Wdr5 (zeige WDR5 ELISA Kits) gene promoter.
Since CTCF and cohesin are required for loop domain formation, our results suggest that chromatin loops are dynamic and frequently break and reform throughout the cell cycle.
Nearly half of all DNase hypersensitivity sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 (zeige RUNX2 ELISA Kits) and/or the chromatin-related CTCF transcription factors.
Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites.
CTCF knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF (zeige BDNF ELISA Kits) and Arc loci.
Here, we show that PARP1 (zeige PARP1 ELISA Kits) and host insulator protein CTCF colocalize at specific sites throughout the EBV genome and provide evidence to suggest that PARP1 (zeige PARP1 ELISA Kits) acts to stabilize CTCF binding and maintain the open chromatin landscape at the active Cp promoter during type III latency. Further, PARP1 (zeige PARP1 ELISA Kits) activity is important in maintaining latency type-specific viral gene expression.
HOTTIP cooperates with CTCF to coordinate HOXA gene expression.
CD4 (zeige CD4 ELISA Kits)(+) T cells showed the greatest increase (threefold) in ORMDL3 (zeige ORMDL3 ELISA Kits) expression in individuals carrying the asthma-risk alleles, where ORMDL3 (zeige ORMDL3 ELISA Kits) negatively regulated interleukin-2 (zeige IL2 ELISA Kits) production. The asthma-risk variants rs4065275 and rs12936231 switched CTCF-binding sites in the 17q21 locus.
Our data reveal that vigilin (zeige HDLBP ELISA Kits) is essential for maintenance of imprinting of IGF2 gene via functional interaction between KH1-7 domains of vigilin (zeige HDLBP ELISA Kits) and zinc-finger domains of CTCF.
This study confirms that haploinsufficiency of CTCF causes distinct clinical features, and that a microdeletion encompassing CTCF could cause a recognisable CTCF deletion syndrome. Perturbed DNA methylation at CTCF binding sites, not at imprinted loci, may underlie the pathomechanism of the syndrome.
structural studies show that the sequence-specific interactions between zinc fingers and CTCF-binding sites determine the directionality and conservation of CTCF recognition.
CTCF may be a key factor that contributes to gene co-mutations in cancer.
results support a model in which YY1 (zeige YY1 ELISA Kits) acts as an architectural protein to connect developmentally regulated looping interactions; the location of YY1 (zeige YY1 ELISA Kits)-mediated interactions may be demarcated in development by a preexisting topological framework created by constitutive CTCF-mediated interactions.
The MeCP2, a protein whose mutated forms are involved in Rett syndrome; and CTCF, a constitutive transcriptional insulator.
The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL.
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor